Neonatal Activation of Alcohol‐Related Prenatal Memories: Impact on the First Suckling Response

Abate, Paula; Varlinskaya, Elena I.; Cheslock, Sarah J.; Spear, Norman E.; Molina, Juan Carlos

doi:10.1111/j.1530-0277.2002.tb02450.x

Cited by 49 publications

(18 citation statements)

References 56 publications

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“…Pups prenatally exposed to paired experiences between cineole and the onset of alcohol intoxication, exhibited patterns of orofacial responses (mouthing) elicited by the CS that were significantly different from those found in infants that had originally experienced the CS and the US separated by a significant time delay (4 hr) or pups born to water treated females (Abate et al, 2000;Abate, Spear, & Molina, 2001). Using a similar experimental strategy it was also observed that neonates prenatally exposed to cineole associated with alcohol intoxication show heightened responsiveness to a nutritive surrogate nipple in the presence of the odor employed as a CS during late gestation (Abate, Varlinskaya, Cheslock, Spear, & Molina, 2002).…”

Section: Alcohol Responsiveness As a Function Of Fetal Experiences Wimentioning

confidence: 59%

The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndrome

Molina

Spear

et al. 2007

Developmental Psychobiology

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As has been repeatedly demonstrated, alcohol can exert deleterious morphological and physiological effects during early stages in development. The present review examines nonteratological links existing between alcohol and ontogeny. Human and animal studies are taken into consideration for the analysis of fetal, neonatal, infantile, adolescent, and adult responsiveness to the drug. Sensitivity to alcohol's chemosensory and postabsorptive properties, as well as learning and memory processes mediated by such properties, are examined from this developmental perspective. The studies under discussion indicate that, within each stage in development, we can trace alcohol-related experiences capable of determining or modulating alcohol seeking and intake patterns.

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Section: Alcohol Responsiveness As a Function Of Fetal Experiences Wimentioning

confidence: 59%

The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndrome

Molina

Spear

et al. 2007

Developmental Psychobiology

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“…How the presence or absence of the prenatal CS modulated the structure of the first suckling response was addressed through tests with a surrogate nipple that delivered milk as a consequence of neonatal attachment (122)(123)(124). Neonates prenatally exposed to cineole associated with ethanol intoxication exhibited heightened responsiveness to the nutritive surrogate nipple when in the presence of the odor used as a CS during gestation (125). These results are depicted in Figure 2.…”

Section: Fetal Learning About Ethanol Derived From Maternal Intoxicatmentioning

confidence: 85%

“…This correlational study strongly suggested that physiologic changes in the prenatal milieu, derived from the state of ethanol intoxication, act as important components in modulating fetal ethanol learning processes (118,125,141,142). Although these results cannot address a causal relation between hypothermia as a US and fetal learning about ethanol's chemosensory cues, these results emphasize that analysis of early memories involving experiences with ethanol requires vigilant consideration of contingencies existing between ethanol's sensory properties and a variety of ethanol's physiologic consequences.…”

Section: Fetal Learning About Ethanol Derived From Maternal Intoxicatmentioning

confidence: 99%

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Fetal Learning About Ethanol and Later Ethanol Responsiveness: Evidence Against “Safe” Amounts of Prenatal Exposure

Abate

Pueta

Spear

et al. 2008

Exp Biol Med (Maywood)

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Near-term fetuses of different mammalian species, including humans, exhibit functional sensory and learning capabilities. The neurobiological literature indicates that the unborn organism processes sensory stimuli present in the amniotic fluid, retains this information for considerable amounts of time, and is also capable of associating such stimuli with biologically relevant events. This research has stimulated studies aimed at the analysis of fetal and neonatal learning about ethanol, a topic that constitutes the core of the present review. Ethanol has characteristic sensory (olfactory, taste, and trigeminal) attributes and can exert pharmacologic reinforcing effects. The studies under examination support the hypothesis that low to moderate levels of maternal ethanol intoxication during late pregnancy set the opportunity for fetal learning about ethanol. These levels of prenatal ethanol exposure do not generate evident morphologic or neurobehavioral alterations in the offspring, but they exert a significant impact upon later ethanol-seeking and intake behaviors. Supported by preclinical and clinical findings, this review contributes to strengthening the case for the ability of prenatal ethanol exposure to have effects on the postnatal organism. Keywords ethanol; fetal learning; associative conditioningThis review analyzes the impact of low to moderate prenatal levels of exposure to ethanol on later responding to ethanol and stimuli associated with ethanol. These levels of ethanol exposure might be viewed as "safe" but nevertheless have negative effects that might not be noticed for many years.We previously reviewed the literature, examining possible associations between early ontogenetic experiences with alcohol and subsequent affinity for ethanol ingestion and sensitivity to its reinforcing effects (postabsorptive consequences that increase behaviors aimed at obtaining ethanol or that generate preferences to stimuli signaling such consequences) (1). This review took into account fetal and infantile experiences involving acute or chronic exposure to ethanol and how they exerted significant effects upon subsequent ethanol 1To whom correspondence should be addressed at Instituto Ferreyra,

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“…The odor, taste and somatosensory stimulation provided by EtOH in the amniotic fluid is perceived by the fetus (Domínguez et al, 1996). The fetus can also experience EtOH's postabsorptive pharmacological effects (Domínguez et al, 1996; Abate et al, 2000), originating the opportunity for the development of an association between EtOH's chemosensory properties and its pharmacological effects (Abate et al, 2000, 2001, 2002). Additionally, it has been proposed that exposure to EtOH during early ontogeny involves learning about positive effects of the drug, since at this developmental stage rats seem more susceptible to EtOH's effects than later in life (Molina et al, 2007b; Pautassi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Acetaldehyde reinforcement and motor reactivity in newborns with or without a prenatal history of alcohol exposure

March¹,

Cullere²,

Abate³

et al. 2013

Front. Behav. Neurosci.

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Animal models have shown that early ontogeny seems to be a period of enhanced affinity to ethanol. Interestingly, the catalase system that transforms ethanol (EtOH) into acetaldehyde (ACD) in the brain, is more active in the perinatal rat compared to adults. ACD has been found to share EtOH's behavioral effects. The general purpose of the present study was to assess ACD motivational and motor effects in newborn rats as a function of prenatal exposure to EtOH. Experiment 1 evaluated if ACD (0.35 μmol) or EtOH (0.02 μmol) supported appetitive conditioning in newborn pups prenatally exposed to EtOH. Experiment 2 tested if prenatal alcohol exposure modulated neonatal susceptibility to ACD's motor effects (ACD dose: 0, 0.35 and 0.52 μmol). Experiment 1 showed that EtOH and ACD supported appetitive conditioning independently of prenatal treatments. In Experiment 2, latency to display motor activity was altered only in neonates prenatally treated with water and challenged with the highest ACD dose. Prenatal EtOH experience results in tolerance to ACD's motor activity effects. These results show early susceptibility to ACD's appetitive effects and attenuation of motor effects as a function of prenatal history with EtOH, within a stage in development where brain ACD production seems higher than later in life.

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Neonatal Activation of Alcohol‐Related Prenatal Memories: Impact on the First Suckling Response

Cited by 49 publications

References 56 publications

The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndrome

The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndrome

Fetal Learning About Ethanol and Later Ethanol Responsiveness: Evidence Against “Safe” Amounts of Prenatal Exposure

Acetaldehyde reinforcement and motor reactivity in newborns with or without a prenatal history of alcohol exposure

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