Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

Abstract

This is the first report of neonatal adiposity as a predictor of AD at 6 and 12 months of age in a well-characterized atopic disease-specific birth cohort.

Neonatal risk factors of atopic dermatitis in Denmark – Results from a nationwide register‐based study

“… Multiple mechanisms could explain an inverse association, for example, (i) facilitated penetration of allergens across an immature skin barrier, leading to induction of immune tolerance instead of sensitization; (ii) reduced diversity of the intestinal microflora possibly affecting the development of tolerance; and (iii) shorter period of natural exposure to Th2 cytokines during pregnancy, which could bias the immune system away from a Th2 phenotype . The positive association between AD and birthweight in the first year of life is in accordance with a recent study which showed that neonatal adiposity was a risk factor for AD .…”

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE Birth Cohort Study

“…Our findings of no effect modification of intrauterine vitamin D exposure on persistent eczema in the first 24 months builds upon our comprehensive evaluation of persistent, transient and late‐onset eczema in the first year of life, in which we identified inherited risk and neonatal adiposity as risk factors for persistent eczema . Our study is one of very few to evaluate the relationship of in utero 25(OH)D with the persistent eczema phenotype.…”

Is atopic dermatitis associated with obesity? A systematic review of observational studies

“…In a non‐interventional, single‐centre birth cohort study, O'Donovan et al . sought to describe risk factors for AD in the first year of life.…”

“…In a non-interventional, single-centre birth cohort study, O'Donovan et al 24 sought to describe risk factors for AD in the first year of life. All women participating in the Screening for Pregnancy Endpoints (SCOPE) study 25 (a global multicentre longitudinal cohort study of low-risk primiparous women, with the main aim of developing screening tests for the major diseases of late pregnancy) were invited to partake in the study of risk factors for AD in the first year of life.…”