Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze

Ribas, Valdenilson Ribeiro; Aniceto, Helena Karine Rufino; Martins, Hugo André de Lima; Ribas, Ketlin Helenise dos Santos; Guerra-Ribas, Renata de Melo; Fraga, Simone do Nascimento; Ribeiro-Ribas, Valéria; Vasconcelos, Célia Maria Mendes; Viana, Marcelo Tavares; Manhães-de-Castro, Raul

doi:10.1590/s0004-282x2008000600013

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Although only a handful of studies have examined the effects of neonatal antidepressant exposure on behavior in the elevated plus maze test, the majority of the studies, like our study, did not report any changes in anxiety-like behavior in rats or mice (Ansorge et al, 2008; Popa et al, 2008; Ribas et al, 2008). Our data suggests that neonatal citalopram exposure does not have any long-term effects on anxiety-like behavior or exploration in adult rats.…”

Section: Discussionmentioning

confidence: 51%

Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat

et al. 2012

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Neonatal exposure to antidepressants produces lasting impairments in male sexual behavior. Although perturbation of the serotonin system during neonatal life has been implicated in the long-term behavioral effects of neonatal antidepressant exposure, dose-response studies were necessary to confirm that inhibition of the serotonin transporter during the neonatal period is sufficient to produce impairments in sexual behavior. Therefore, the present study examined the dose-response effects of neonatal citalopram exposure on sexual behavior. In addition, the effects of exposure on anxiety-related behavior were examined since alterations in this behavioral measure could affect sexual behavior. Male Long-Evans rats were injected subcutaneously with citalopram (CTM) in one of three doses (5, 10 or 20 mg/kg/day), or saline (SAL) in a volume of 0.1 ml twice daily (07:00 and 14:00h) from PN8 to PN21. The rats were tested as adults (>PN90) for anxiety-like behavior and exploration in the elevated plus maze test and sexual behavior. Neonatal citalopram exposure produced persistent reductions in male sexual behavior characterized by significant dose-dependent reductions in the percentage of male rats displaying mounting as well as dose-dependent reductions in the number of mounts and mount latency. Neonatal citalopram exposure also produced significant dose-dependent linear trends for reductions in intromission and ejaculation behavior. However, neonatal SSRI exposure was not found to produce any effects on exploration or anxiety-like behavior in the elevated plus maze test. The present findings support the hypothesis that inhibition of the serotonin transporter during neonatal life by an SSRI is directly responsible for the long-term effects on male sexual behavior.

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Section: Discussionmentioning

confidence: 51%

Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat

et al. 2012

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“…For instance, neonatal fluoxetine exposure increased anxiety levels, as shown by decreased locomotor activity and increased immobility time in the open field (Ansorge et al 2004;Jiang et al 2009), reduced locomotor activity in the EPM test (Ribas et al 2008), and increased latency to start eating in the noveltysuppressed feeding test (Jiang et al 2009). In addition, neonatal fluoxetine exposure affected depression-like behavior, as reflected by the increased immobility time in the forced swim test (Hansen et al 1997), and increased anhedonia (Popa et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

et al. 2011

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“…Likewise, several studies, utilizing medications at therapeutically relevant doses, demonstrate that prenatal or early postnatal exposure to an SSRI in mice increases anxiety-like behavior in adulthood (Ansorge et al 2004, 2008; Noorlander et al 2008; Olivier et al 2011; Smit-Rigter et al 2012). However, several studies using SSRI during development did not result in increased anxiety in adulthood (Hansen et al 1997; Bairy et al 2007; Popa et al 2008; Ribas et al 2008; Harris et al 2011; Rayen et al 2011) (Table 1). These discrepancies may arise from the differences between studies with respect to paradigms, strain of rodents, and type and timing of the SSRI administered.…”

Section: Serotonin Manipulation Effects On Brain and Behavior: Preclimentioning

confidence: 95%

Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise

2013

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Rationale Women are increasingly prescribed selective serotonin reuptake inhibitors (SSRIs) during pregnancy, with potential implications for neurodevelopment. Whether prenatal SSRI exposure has an effect on neurodevelopment and behavior in the offspring is an important area of investigation. Objectives The aim of this paper was to review the existing preclinical and clinical literature of prenatal SSRI exposure on serotonin-related behaviors and markers in the offspring. The goal is to determine if there is a signal in the literature that could guide clinical care and/or inform research. Results Preclinical studies (n = 4) showed SSRI exposure during development enhanced depression-like behavior. Half of rodent studies examining anxiety-like behavior (n = 13) noted adverse effects with SSRI exposure. A majority of studies of social behavior (n = 4) noted a decrease in sociability in SSRI exposed offspring. Human studies (n = 4) examining anxiety in the offspring showed no adverse effects of prenatal SSRI exposure. The outcome of one study suggested that children with autism were more likely to have a mother who was prescribed an SSRI during pregnancy. Conclusions Preclinical findings in rodents exposed to SSRIs during development point to an increase in depression- and anxiety-like behavior and alteration in social behaviors in the offspring, though both the methods used and the findings were not uniform. These data are not robust enough to discourage use of SSRIs during human pregnancy, particularly given the known adverse effects of maternal mental illness on pregnancy outcomes and infant neurodevelopment. Future research should focus on consistent animal models and prospective human studies with larger samples.

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Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze

Cited by 8 publications

References 23 publications

Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat

Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise

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