Neonatal adrogen treatment and sexual behavior in males of three inbred strains of mice

Vale, Jack R.; Ray, Donald; Vale, Carol A.

doi:10.1002/dev.420070512

Cited by 16 publications

(9 citation statements)

References 17 publications

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“…The reduction in testis weights, in the treated animals, is in agreement with the findings of Vale et al (1974) and Bronson and Desjardins (1968). These authors also found decreases in seminal vesicle weights, a result not recorded in this experiment.…”

Section: Discussionsupporting

confidence: 93%

Influence of neonatal injections of testosterone propionate on sexual behavior and plasma testosterone levels in the male house mouse

Batty

1979

Developmental Psychobiology

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Section: Discussionsupporting

confidence: 93%

Influence of neonatal injections of testosterone propionate on sexual behavior and plasma testosterone levels in the male house mouse

Batty

1979

Developmental Psychobiology

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“…The finding of intraspecific variation in hormone sensitivity in an outbred, naturally occurring species is similar to findings of strain differences in behavioral sensitivity to exogenously administered androgens (21)(22)(23). Since the animals used in this study were collected from a variety of sites, it remains to be determined whether these results reflect population differences and/or are due to enzyme deficiences in nonresponding individuals (24).…”

Section: Discussionsupporting

confidence: 69%

Hormonal Control of Male Reproductive Behavior in the Lizard, Anolis carolinensis: Role of Testosterone, Dihydrotestosterone, and Estradiol*

et al. 1978

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The androgen aromatization hypothesis was examined in the male lizard, Anolis carolinensis. After castration, sc silastic implants of testosterone (T) restored both challenge and courtship behavior, while dihydrotestosterone (DHT) or 17beta-estradiol (E) had no effect on male behaviors. Both T and DHT, but not E, stimulated hypertrophy and colloid production by the renal sex segment, a secondary sexual characteristic of male lizards. In two separate studies, castrates received DHT in combination with E. In each replicate, half of the castrates responded with increases in courtship behavior after hormone treatment. Epithelial cell height of the sex segment of all DHT and E-treated castrates was comparable to T- or DHT-treated castrates, but colloid production was not stimulated. These experiments indicate that in this species, treatment with T stimulates both sexual behavior and secondary sex character development, whereas treatment with E alone is without effect centrally or peripherally.

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“…The sex chromosome effect reported here, however, is unlikely to be mediated by group differences in androgen secretion. Had the XY Ϫ genotype caused a greater secretion of testosterone perinatally relative to the XX genotype, the difference in these groups should have been detected in more than one phenotype because most of the phenotypes measured are masculinized by testosterone or its metabolites, probably during different but overlapping critical periods (Vale et al, 1973;Wagner and Clemens, 1989;Wang et al, 1993;Simerly et al, 1997). Thus, each system can be considered a sensitive barometer of levels of gonadal steroids during perinatal development, and the lack of sex chromosome effects in most of the systems is evidence against a sex chromosome effect on the levels of circulating gonadal steroids.…”

Section: Discussionmentioning

confidence: 99%

A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits

et al. 2002

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We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion of Sry from the Y and subsequent insertion of an Sry transgene onto an autosome), so that the determination of testis development occurred independently of the complement of X or Y chromosomes. We compared XX and XY mice with ovaries (females) and XX and XY mice with testes (males). These comparisons allowed us to assess the effect of sex chromosome complement (XX vs XY) independent of gonadal status (testes vs ovaries) on sexually dimorphic neural and behavioral phenotypes. The phenotypes included measures of male copulatory behavior, social exploration behavior, and sexually dimorphic neuroanatomical structures in the septum, hypothalamus, and lumbar spinal cord. Most of the sexually dimorphic phenotypes correlated with the presence of ovaries or testes and therefore reflect the hormonal output of the gonads. We found, however, that both male and female mice with XY sex chromosomes were more masculine than XX mice in the density of vasopressin-immunoreactive fibers in the lateral septum. Moreover, two male groups differing only in the form of their Sry gene showed differences in behavior. The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain.

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Neonatal adrogen treatment and sexual behavior in males of three inbred strains of mice

Cited by 16 publications

References 17 publications

Influence of neonatal injections of testosterone propionate on sexual behavior and plasma testosterone levels in the male house mouse

Influence of neonatal injections of testosterone propionate on sexual behavior and plasma testosterone levels in the male house mouse

Hormonal Control of Male Reproductive Behavior in the Lizard, Anolis carolinensis: Role of Testosterone, Dihydrotestosterone, and Estradiol*

A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits

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