Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis

Gamal, Taha Soliman; Madiha, A; Hanan, Mostafa Kamel; Abdel-Azeem, Mohamed El-Mazary; Marian, Gamil S

doi:10.3390/children4050037

Cited by 21 publications

(29 citation statements)

References 36 publications

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“…The commonest mode of delivery was cesarean section (92%) which higher than the results obtained by Gamal et al [19] who found that, CS was 72%. However, the results of the current study agree with Aye et al [12] who found no significant difference between cases and controls regarding mode of delivery.…”

Section: Discussioncontrasting

confidence: 52%

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Impact of serum level of vitamin D on term neonates with early onset sepsis

Soliman

Sakr

Emran

et al. 2019

International Journal of Medical Arts

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Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates. Methodology: This is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis. Results: vitamin D level showed significant negative correlation with sepsis, Creactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis. Conclusions: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.

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Section: Discussioncontrasting

confidence: 52%

“…Rass et al [17] found a significant difference sepsis and healthy groups regarding RBCs, PLT, WBC, neutrophil and CRP. In addition, Gamal et al [19] studied 50 neonates with EOS and reported significant decrease of hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Impact of serum level of vitamin D on term neonates with early onset sepsis

Soliman

Sakr

Emran

et al. 2019

International Journal of Medical Arts

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“…26.4 ng/ml) 22. Gamal et al found not only significantly lower vitamin D levels in newborns with EOS as compared with controls, but also significant inverse correlations between vitamin D levels and all sepsis markers 23. Of note, all these studies reported a positive correlation between maternal and infant vitamin D levels.…”

Section: Discussionmentioning

confidence: 95%

Neonatal Vitamin D status and the risk of neonatal sepsis

Özdemir

Çağ²

2019

Pak J Med Sci

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Objective: To evaluate the maternal and neonatal 25-hydroxyvitamin D [25(OH)D] levels and the effect of 25(OH)D levels on the development of neonatal sepsis. Methods: This prospective study was performed in the neonatal intensive care unit of Medicine Hospital/Biruni University between November 2017 and September 2018. Fifty one term infants with sepsis group and 56 term infants with control group were included in this study. Blood samples for whole blood count, CRP, Ca, P, ALP, 25(OH)D and culture were obtained from all neonates. Results: Mean vitamin D levels for the neonates and their mothers were found to be 12.4±8.5 ng/ml and 13±8.7 ng/ml, respectively. There was a significant correlation between maternal and newborn 25(OH)D levels (r=0.72, p<0.01). The number of the newborns with vitamin D deficiency was significantly higher in the sepsis group (n=31, 60.8%) than in the control group (n=30, 53.6%; p=0.00), corresponding to significantly lower levels of vitamin D in the sepsis group (11±5.5 ng/ml vs. 13.8±10.6 ng/ml; p=0.012). Similarly, maternal vitamin D levels was significantly lower in the sepsis group than in the control group (10.8±5.6 ng/ml vs. 14.9±10 ng/ml; p=0.001). Conclusion: Our findings suggest that there may be an association between vitamin D deficiency and neonatal sepsis. How to cite this:Ozdemir AA, Cag Y. Neonatal Vitamin D status and the risk of neonatal sepsis. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.342 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Neonatal early-onset sepsis (case group; NEOS) consisted of 32 terms NICU hospitalized neonates as suspected sepsis in the patients’ group. EOS diagnosis was considered based on clinical and laboratory findings during the first 72 h of life to have a high potential NEOS according to the criteria defined by Soliman Gamal et al, 2017, such as temperature instability, heart rate dysrhythmia, poor feeding or intolerance, weight loss, abdominal distension, and necrotizing enterocolitis, and respiratory clinical signs containing distress, supplemental oxygen, mechanical ventilation requirement, apnea, tachycardia or bradycardia, and hypoxemia, as well as positive blood culture, elevates C-reactive protein (CRP) and hematologic cell blood count findings [17].…”

Section: Methodsmentioning

confidence: 99%

Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors

et al. 2019

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Background The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors. Methods A case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 2016) and their mothers were enrolled. The case group consisted of 32 NICU term hospitalized neonates due to neonatal early-onset sepsis. Thirty-two term newborns that referred to hospital for rule out hyperbilirubinemia during the first 72 h of life were also considered as the control. Results Sixty- four mothers with mean age 28.76 ± 6.60 years and mean gestational age 39.64 ± 1.62 weeks entered the study. There was a significant correlation between sepsis and older age of mothers and low Apgar score ( P -value = 0.02, 0.01 respectively). The maternal vitamin D serum level was reversely correlated with neonatal sepsis occurrence ( P -value = 0.03). There was a significant correlation between maternal vitamin D supplement intake during pregnancy and lower risk for neonatal sepsis ( P -value = 0.003). Conclusion The level of maternal serum Vitamin D was inversely correlated with neonatal sepsis occurrence and intake of vitamin D supplement during pregnancy could decrease the risk of early neonatal sepsis.

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Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis

Cited by 21 publications

References 36 publications

Impact of serum level of vitamin D on term neonates with early onset sepsis

Impact of serum level of vitamin D on term neonates with early onset sepsis

Neonatal Vitamin D status and the risk of neonatal sepsis

Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors

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