Some theorists and researchers consider perinatal anoxia as a cause of mental retardation. Research investigating the relationship between perinatal anoxia and intellectual functioning in humans is critically reviewed. It is suggested that the inconsistent findings are due to methodological differences varying on three research dimensions: (a) assessment of anoxia, (6) type of experimental design, and (c) control variables. Four tentative conclusions are advanced: (a) intellectual impairment resulting from anoxia is most often found in infants and preschoolers than in older children and adolescents, ( 6) anoxic subjects as a group are not mentally retarded, (c) anoxia may increase the probability of being mentally retarded, and (d) deficits in specific intellectual abilities in anoxic subjects are not known as yet. Studies using matched-group designs are criticized. Future perinatal anoxia research using predictive models such as multiple regression are suggested and briefly discussed.