Neonatal Appendicitis with Cow Milk Protein Allergy

Shah, Aditi; Mandke, Jui

doi:10.1007/s13312-020-1793-y

Cited by 2 publications

(4 citation statements)

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“…Cow milk protein allergy (CMPA) [ 1 ], an abnormal immunological reaction to cow's milk protein, is the most common allergic disease in infants [ 2 ]. According to statistics, the global incidence of CMPA in infants and young children is 1.9% to 4.9% [ 3 ], and the incidence of CMPA in infants and young children under 2 years old in China is about 2% to 3% [ 1 ], and it has shown a rising trend in recent years. The cow's milk protein is the main source of dietary protein for infants, so cow's milk is a major food allergen in children under 3 years of age.…”

Section: Introductionmentioning

confidence: 99%

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Wen-ying¹,

Zhu²,

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to analyze the clinical effect of standardized dietary avoidance therapy on children with cow milk protein allergy (CMPA) and its effect on the intestinal flora. Methods. The clinical data of 200 children with CMPA from our hospital from February 2020 to May 2021 were collected, and they were divided into a study group (n = 100) and a routine group (n = 100) based on different intervention modalities. The routine group received routine treatment, whereas the standardized dietary avoidance therapy was used in the study group. The clinical effects and related intestinal microflora indexes of the two groups were analyzed and compared. Results. There was no significant difference in the incidence of related symptoms between the two groups before intervention ( P > 0.05 ), and the conditions of the two groups were improved after intervention. The incidences of skin (2%), digestive tract (3.00%), and respiratory tract (1.00%) in the study group were significantly lower than those in the routine group (14.00%, 18.00%, and 11.00%) ( P > 0.05 ). The time taken for complete remission of symptoms and milk tolerance months in the study group (41.23 ± 23.68, 13.28 ± 6.17) were significantly shorter than those in the routine group (145.14 ± 66.74, 16.17 ± 8.05) ( P > 0.05 ). The values of height, weight, and head circumference (HC) of children in the study group (79.88 ± 2.18, 11.09 ± 1.34, 47.88 ± 0.63) were higher than those in the routine group (76.21 ± 2.34, 9.81 ± 1.18, 45.98 ± 0.59) ( P > 0.05 ). The levels of Lactobacillus and Enterococcus (9.95 ± 0.89, 11.31 ± 1.05) in the study group were higher than those in the routine group (9.11 ± 0.74, 10.38 ± 0.94), and the levels of yeast-like fungi in the study group (3.08 ± 0.24) were lower than those of the routine group (3.82 ± 0.31) ( P > 0.05 ). Conclusion. The standardized dietary avoidance therapy is remarkable in the treatment of CMPA, in which the children were able to tolerate ordinary milk earlier, and the intestinal flora was significantly improved, thereby promoting the growth and development of children. It therefore merits clinical promotion.

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Section: Introductionmentioning

confidence: 99%

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Wen-ying¹,

Zhu²,

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…With cross‐referencing, eight additional eligible articles were identified. In total, 131 articles were included in this systematic review 3,6,12–140 . Figure 1 provides the PRISMA flowchart.…”

Section: Resultsmentioning

confidence: 99%

“…A bowel resection with primary anastomosis was performed in an additional seven (4%) of the 178 surgically treated patients with abdominal appendicitis (postoperative complications not included). Reported indications were: N = 2 ileocaecal resection due to perforation of the caecum or fistula of the appendix into caecum, N = 1 resection of a part of ascending colon due to local lesion caused by adherent appendix, N = 1 resection terminal ileum due to adherent appendix and cystic lesion, N = 1 Meckel's diverticulum, N = 1 adherent ileal loop, N = 1 old perforation terminal ileum 44,45,69,98,124,131,135 . In one patient a diverticulectomy of a Meckel's diverticulum was performed and in three patients a Ladd's procedure 20,24,104,134 …”

Section: Resultsmentioning

confidence: 99%

“…Reported indications were: N = 2 ileocaecal resection due to perforation of the caecum or fistula of the appendix into caecum, N = 1 resection of a part of ascending colon due to local lesion caused by adherent appendix, N = 1 resection terminal ileum due to adherent appendix and cystic lesion, N = 1 Meckel's diverticulum, N = 1 adherent ileal loop, N = 1 old perforation terminal ileum. 44 , 45 , 69 , 98 , 124 , 131 , 135 In one patient a diverticulectomy of a Meckel's diverticulum was performed and in three patients a Ladd's procedure. 20 , 24 , 104 , 134 …”

Section: Resultsmentioning

confidence: 99%

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Appendicitis and its associated mortality and morbidity in infants up to 3 months of age: A systematic review

The,

Derikx

et al. 2023

Health Science Reports

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Background and AimsAlthough appendicitis is rare in young infants, the reported mortality is high. Primary aim of this systematic review was to provide updated insights in the mortality and morbidity (postoperative complications, Clavien‐Dindo grades I–IV) of appendicitis in infants ≤3 months of age. Secondary aims comprised the evaluation of patient characteristics, diagnostic work‐up, treatment strategies, comorbidity, and factors associated with poor outcome.MethodsThis systematic review was reported according to the PRISMA statement with a search performed in Pubmed, Embase and Web of Science (up to September 5th 2022). Original articles (published in English ≥1980) reporting on infants ≤3 months of age with appendicitis were included. Both patients with abdominal appendicitis and herniated appendicitis (such as Amyand's hernia) were considered. Data were provided descriptively.ResultsIn total, 131 articles were included encompassing 242 cases after identification of 4294 records. Overall, 184 (76%) of the 242 patients had abdominal and 58 (24%) had herniated appendicitis. Two‐hundred (83%) of the patients were newborns (≤28 days) and 42 (17%) were infants between 29 days and ≤3 months of age. Either immediate, or after initial conservative treatment, 236 (98%) patients underwent surgical treatment. Some 168 (69%) patients had perforated appendicitis. Mortality was reported in 20 (8%) patients and morbidity in an additional 18 (8%). All fatal cases had abdominal appendicitis and fatal outcome was relatively more often reported in newborns, term patients, patients with relevant comorbidity, nonperforated appendicitis and those presented from home.ConclusionMortality was reported in 20 (8%) infants ≤3 months of age and additional morbidity in 18 (8%). All patients with fatal outcome had abdominal appendicitis. Several patient characteristics were relatively more often reported in infants with poor outcome and adequate monitoring, early recognition and prompt treatment may favour the outcome.

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Neonatal Appendicitis with Cow Milk Protein Allergy

Cited by 2 publications

References 3 publications

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Appendicitis and its associated mortality and morbidity in infants up to 3 months of age: A systematic review

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