Neonatal Arterial Stroke

Ricci, Daniela

doi:10.1007/978-88-470-1405-3_139

Cited by 1 publication

(1 citation statement)

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“…The degeneration occurring in all cortical layers, an observation not always present in cases of neonatal stroke is most likely dependent on the position and portion of the occluded artery and the downstream territory. Previously published reports exists describing similar extent of complete cortical degeneration in human perinatal stroke (42), following main-branch MCAO (24,26,29,43,56,68) vs. lenticulostriate branch occlusion, which affects deeper structures and sparing superficial cortical layers. These data are consistent with our own following superficial PCAca occlusion.…”

Section: Discussionmentioning

confidence: 88%

A Reproducible and Translatable Model of Focal Ischemia in the Visual Cortex of Infant and Adult Marmoset Monkeys

Teo

Bourne

2014

Brain Pathology

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Models of ischemic brain injury in the nonhuman primate (NHP) are advantageous for investigating mechanisms of central nervous system (CNS) injuries and testing of new therapeutic strategies. However, issues of reproducibility and survivability persist in NHP models of CNS injuries. Furthermore, there are currently no pediatric NHP models of ischemic brain injury. Therefore, we have developed a NHP model of cortical focal ischemia that is highly reproducible throughout life to enable better understanding of downstream consequences of injury. Posterior cerebral arterial occlusion was induced through intracortical injections of endothelin-1 in adult (n = 5) and neonatal (n = 3) marmosets, followed by magnetic resonance imaging (MRI), histology and immunohistochemistry. MRI revealed tissue hyperintensity at the lesion site at 1-7 days followed by isointensity at 14-21 days. Peripheral macrophage and serum albumin infiltration was detected at 1 day, persisting at 21 days. The proportional loss of total V1 as a result of infarction was consistent in adults and neonates. Minor hemorrhagic transformation was detected at 21 days at the lesion core, while neovascularization was detected in neonates, but not in adults. We have developed a highly reproducible and survivable model of focal ischemia in the adult and neonatal marmoset primary visual cortex, demonstrating similar downstream anatomical and cellular pathology to those observed in post-ischemic humans.

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