Neonatal Asymmetric Crying Facies: A New Look at an Old Problem

Sapin, Samuel O.; Miller, Alvin A.; Bass, Harold N.

doi:10.1177/000992280504400202

Cited by 37 publications

(52 citation statements)

References 31 publications

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“…(5)(18) Agenesis or hypoplasia of the DAOM can be differentiated from the traumatic cause of ACF by electromyographic testing showing a paucity of the motor units but no fibrillation and normal values for excitability and conduction of the facial nerve. (5) Prognosis ACF due to DAOM hypoplasia is noted primarily in the neonatal period and becomes less obvious at a later age, as functions of other facial muscles and smiling dominate the child's facial expressions. (12) ACF due to nerve compression usually resolves spontaneously.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…In those cases due to faulty muscle development, spontaneous remission sometimes is less likely, and consultation with a plastic surgeon may be advisable. (5) …”

Section: Differential Diagnosismentioning

confidence: 99%

“…They further emphasized the possible causes of ACF, coined the terms "traumatic theory" and "faulty developmental theory," and established an investigative evaluation for ACF. (5) origin whose insertions blend with the muscular substance of the lip, with action on the lower lip. The DAOM has its origin on the mandible, extends upward, and inserts into the OOM.…”

Section: Introductionmentioning

confidence: 99%

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Asymmetric Crying Facies

Shapira

Borochowitz

2009

NeoReviews

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Drs Shapira and Borochowitz have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/ investigative use of a commercial product/ device. Objectives After completing this article, readers should be able to: 1. Know the causes of asymmetric crying facies (ACF). 2. Differentiate ACF from true facial paralysis. 3. Recognize the malformations that might be associated with ACF. 4. Evaluate an infant who has ACF. AbstractAsymmetric crying facies (ACF) refers to a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side. It is a minor anomaly found in 1 per 160 live births and is caused by hypoplasia or agenesis of the depressor anguli oris muscle (DAOM) or compression of one of the branches of the facial nerve. Associated major and minor malformations as well as deformations have been described. The risk of associated major anomalies with ACF is 3.5-fold higher compared with the general population. Such anomalies are most common in the cardiovascular system and cervicofacial region. Certain clinical signs may differentiate ACF from true facial paralysis. Physical findings, electromyography, and ultrasonography studies can help differentiate between the two causes of ACF. An approach to the diagnostic evaluation is suggested, both for initial evaluation and for decisions about subsequent treatment of ACF.

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Section: Differential Diagnosismentioning

confidence: 99%

“…In those cases due to faulty muscle development, spontaneous remission sometimes is less likely, and consultation with a plastic surgeon may be advisable. (5) …”

Section: Differential Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Asymmetric Crying Facies

Shapira

Borochowitz

2009

NeoReviews

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“…Mechanical pressure during labor has been suggested as a possible mechanism underlying ACF and DAOM dysfunction [Sapin et al, 2005]. In the present The sum of major malformations listed is higher than the number of infants with these malformations since occasionally, more than one occurred in the same subject.…”

Section: Discussionmentioning

confidence: 49%

“…Recent evidence suggests that the 22q11 microdeletion, a well-known genetic cause of facial and cardiac anomalies, is more prevalent in ACF infants [Bawle et al, 1998;Innes, 2001]. Another possible cause of ACF is nerve compression occurring during labor [Sapin et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Increased rate of major birth malformations in infants with neonatal “asymmetric crying face”: A hospital‐based cohort study

Dubnov-Raz

Merlob

Geva-Dayan

et al. 2007

American J of Med Genetics Pt A

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Asymmetric crying face (ACF) is a minor anomaly found in 3-8 per 1,000 births, which may be associated with other anomalies. Previous studies on this topic included small groups of selected subjects, resulting in large variations in findings. The aim of this study was to examine the characteristics and associated anomalies of newborn infants with ACF compared with the general population of newborn infants. The study included newborn infants delivered between 1993 and 2003 at the Department of Neonatology of Rabin Medical Center, Israel. Charts of all newborns diagnosed with ACF were reviewed for obstetric and neonatal details, then compared with non-ACF newborns. ACF was diagnosed in 258 of 67,289 newborns (0.38%), with left-side predominance (77%). Major malformations were found in 7% of ACF infants, 3.5-fold higher than in the total Israeli population. Mild anomalies were present in 15% of the ACF group, and deformations in 4.6%. There was a higher rate of forceps deliveries in the ACF group (RR = 2.73, 95% CI = 1.37-5.42). ACF was more prevalent among females, and the male:female ratio was lower in the ACF group (0.86 vs. 1.06, P = 0.05). The rate of low-birth-weight infants was 3.9% among ACF infants and 9.6% in the control group (RR = 0.41, 95% CI = 0.23-0.76). No significant between-group difference was found for rates of primiparity, macrosomia, prematurity, postmaturity, or size-for-gestational-age. Thus, ACF is associated with a high rate of major malformations. This should prompt clinicians to seek for additional birth defects in ACF infants.

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Enhanced osteoblast functions on anodized titanium with nanotube‐like structures

Yao

Slamovich

Webster

2007

J Biomedical Materials Res

189

137

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Previous studies have demonstrated increased osteoblast (bone-forming cells) adhesion on titanium and Ti-6Al-4V anodized to possess nanometer features compared with their unanodized counterparts. In this study, osteoblast long-term functions (specifically, synthesis of intracellular proteins, synthesis of intracellular collagen, alkaline phosphatase activity, and deposition of calcium-containing minerals) were determined on titanium anodized to possess either heterogeneous nanoparticles or ordered nanotubes. Titanium was anodized in dilute hydrofluoric acid at 20 V for 20 min to possess nanotubes, while titanium was anodized at 10 V for 20 min to possess nanoparticles. Most importantly, results showed that calcium deposition significantly increased on anodized titanium with nanotube-like structures compared with unanodized titanium and anodized titanium with nanoparticulate structures after 21 days of osteoblast culture. In this manner, the results of the present in vitro study indicated that anodization might be a promising quick and inexpensive method to modify the surface of titanium-based implants to induce better bone cell functions important for orthopedic applications.

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Neonatal Asymmetric Crying Facies: A New Look at an Old Problem

Cited by 37 publications

References 31 publications

Asymmetric Crying Facies

Asymmetric Crying Facies

Increased rate of major birth malformations in infants with neonatal “asymmetric crying face”: A hospital‐based cohort study

Enhanced osteoblast functions on anodized titanium with nanotube‐like structures

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