Neonatal brain abnormalities and memory and learning outcomes at 7 years in children born very preterm

Omizzolo, Cristina; Scratch, Shannon E.; Stargatt, Robyn; Kidokoro, Hiroyuki; Thompson, Deanne K.; Lee, Katherine J.; Cheong, Jeanie L.Y.; Neil, Jeffrey J.; Inder, Terrie E.; Doyle, Lex W.; Anderson, Peter J.

doi:10.1080/09658211.2013.809765

Cited by 108 publications

(98 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The scoring system on which this study was based has been used in 2 studies examining the relationships between TEA MR imaging and cognitive outcomes at 7 years. 24,25 Our results support previous findings at TEA and suggest that the brain changes associated with adverse cognitive outcomes are already present as early as 29 to 35 weeks PMA. 7 Of all MR imaging subscale scores, at early and term MR imaging, DGM demonstrated the strongest relationship with outcome.…”

Section: Discussionsupporting

confidence: 82%

“…22 At TEA, global brain abnormality scores were significantly associated with motor outcomes at 2-years CA 23 ; and cognitive outcomes, at 7 years. 24,25 Deep gray matter scores were significantly associated with poorer attention and processing speeds, memory, and learning. 24,25 With safe earlier MR imaging now possible with MR compatible incubators, valid scoring systems for use earlier than TEA are required.…”

mentioning

confidence: 99%

“…24,25 Deep gray matter scores were significantly associated with poorer attention and processing speeds, memory, and learning. 24,25 With safe earlier MR imaging now possible with MR compatible incubators, valid scoring systems for use earlier than TEA are required. The aim of this study was to validate an MR imaging scoring system previously developed for very preterm infants at TEA in a cohort of infants born Ͻ31-weeks gestational age with MR imaging between 29 and 35 weeks' postmenstrual age (PMA).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

George¹,

Fiori

Fripp

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

George¹,

Fiori

Fripp

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…Very preterm (VPT; ,32 weeks' gestation) children are at increased risk for a range of neuropsychological deficits, including impairments in general intellect, 1 language, 2 visuoperceptual reasoning, 3 learning and memory, 4,5 attention, 6 and executive functioning. 7 Furthermore, neuroimaging studies of preterm infants and children have reported volumetric reductions in gray and white matter tissue, 8 as well as specific brain regions (cerebellum, basal ganglia, amygdala, hippocampi, and corpus callosum).…”

mentioning

confidence: 99%

Free Thyroxine Levels After Very Preterm Birth and Neurodevelopmental Outcomes at Age 7 Years

et al. 2014

Self Cite

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Preterm infants have transiently lowered thyroid hormone levels during the early postnatal period. Past research suggests that low thyroid hormone levels are related to cognitive and developmental deficits in children born preterm. WHAT THIS STUDY ADDS:Contrary to expectations, in this study of children born ,30 weeks' gestation, higher concentrations of free thyroxine over the first 6 weeks of life were associated with poorer cognitive function at 7 years of age. abstract BACKGROUND AND OBJECTIVES: Preterm infants commonly have transient hypothyroxinemia of prematurity after birth, which has been associated with deficits in general intellectual functioning, memory, attention, and academic achievement. However, research has predominantly focused on thyroxine levels in the first 2 weeks of life and outcomes are limited to the preschool period. Our objective was to evaluate the relationships between free thyroxine (fT 4 ) levels over the first 6 weeks after very preterm (VPT) birth with cognitive functioning and brain development at age 7 years. METHODS:A total of 83 infants born VPT (,30 weeks' gestation) had fT 4 concentrations measured postnatally and 2-and 6-week area under the curve (AUC) summary measures were calculated. Follow-up at age 7 years included a neuropsychological assessment and brain MRI. Univariable and multivariable regression modeling was used where AUC for fT 4 was the main predictor of neurodevelopmental outcome at age 7 years.RESULTS: Multivariable modeling revealed that higher, not lower, postnatal fT 4 levels (2-week AUC) were associated with poorer cognitive performances at age 7 years on tasks of verbal learning (P = .02), verbal memory (P = .03), and simple reaction time (P , .001). A similar pattern of results was found when the 6-week AUC was examined. No significant associations between postnatal fT 4 levels and brain volumes at age 7 years were identified. CONCLUSIONS:Results are contradictory to previous observations and suggest that after adjustment for confounders, higher postnatal fT 4 levels in VPT infants, rather than lower levels, may be a marker of adverse neuropsychological development in childhood. Dr Scratch conceptualized and designed the study, analyzed the data, and drafted the initial manuscript; Dr Hunt collected the blood specimens for hormone analysis, was involved in initial cerebral MRI interpretation, assisted with the conceptualization and design of the study, supervised data collection at all time points, and reviewed and revised the manuscript; Dr Thompson supervised the collection and analysis of the MRI scans and reviewed and revised the manuscript; Ms Ahmadzai performed the post-acquisition analysis of the MRI scans and reviewed and revised the manuscript; Dr Doyle assisted with the conceptualization and design of the study, supervised data collection at all time points, and reviewed and revised the manuscript; Dr Inder was involved in initial cerebral MRI interpretation, assisted with the conceptualization and design of the ...

show abstract

“…Preterms also show a higher incidence of neurodevelopmental problems. For example, Omizzolo et al (2014) assessed 'very preterms' at 7 years of age for global, white-matter, cortical grey-matter, deep-grey-matter, and cerebellar abnormalities. They found brain abnormality in the 'very preterms' (<32 weeks) especially with the deep grey-matter and were able to associate these changes with poorer memory and learning performance (immediate memory, working memory, and long-term memory) as compared to full-term Controls.…”

Section: Contingency Learning In Pretermsmentioning

confidence: 99%

Effects of Altered Prenatal Sensory Stimulation on Postnatal Contingency Learning in Bobwhite Quail Neonates (Colinus Virginianus)

Raju¹

View full text Add to dashboard Cite

Neonatal brain abnormalities and memory and learning outcomes at 7 years in children born very preterm

Cited by 108 publications

References 59 publications

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age

Free Thyroxine Levels After Very Preterm Birth and Neurodevelopmental Outcomes at Age 7 Years

Effects of Altered Prenatal Sensory Stimulation on Postnatal Contingency Learning in Bobwhite Quail Neonates (Colinus Virginianus)

Contact Info

Product

Resources

About