NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related venous thrombosis

Ommen, C. Heleen van; Bergman, Klasien A.; Boerma, Marit; Bouma, Heleen A.; Donker, Albertine E.; Gouvernante, Melissa; Hulzebos, Christian V.; Khandour, Dalila; Knol, Ronny; Raets, Marlou A.; Liem, Kian D.; Lingen, Richard A. van; Loo, Moniek van de; Lopriore, Enrico; Putten, Mayke van der; Sol, Jeanine J.; Suijker, Monique H.; Vijlbrief, Daniel C.; Visser, Remco; Weissenbruch, Mirjam M. van

doi:10.1016/j.jtha.2022.11.044

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…In recent years, significant progress has been in research on the influencing factors of thrombosis in children [ 8 ]. Studies have shown that several factors contribute to the incidence of thrombosis in this population, including genetic predisposition, underlying medical conditions, and environmental factors [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the level of the studies varied, and the accuracy of the individual results needs to be further determined [ 10 , 11 ]. For example, the latest large cohort study found differences in risk factors for venous versus arterial thrombosis in neonates and central access device characteristics with neonatal thrombosis in ICU [ 8 ]. Whether male and female, ethnicity, antenatal maternal history, central venous catheters, catheters of different sites, or catheter length are all factors contributing to thrombosis in children and newborns is controversial [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and risk factors for thrombosis in children and newborns: systematic evaluation and meta-analysis

Song

Zhao

et al. 2023

BMC Pediatr

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Background Thrombosis is a serious condition in children and neonates. However, the risk factors for thrombosis have not been conclusively determined. This study aimed to identify the risk factors for thrombosis in children and neonates in Intensive Care Unit (ICU) through a meta-analysis to better guide clinical treatment. Methods A systematic search of electronic databases (PubMed, Embase, Cochrane Library, WOS, CNKI, Wanfang, VIP) was conducted to retrieve studies from creation on 23 May 2022. Data on the year of publication, study design, country of origin, number of patients/controls, ethnicity, and type of thrombus were extracted. The publication bias and heterogeneity between studies were assessed, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effects models. Results A total of 18 studies met the inclusion criteria. The incidence of thrombosis in children was 2% per year (95% CI 1%-2%, P < 0.01). Infection and sepsis (OR = 1.95, P < 0.01), CVC (OR = 3.66, [95%CL 1.78–7.51], P < 0.01), mechanical ventilation (OR = 2.1, [95%CL1.47–3.01], P < 0.01), surgery (OR = 2.25, [95%CL1.2–4.22], P < 0.01), respiratory distress (OR = 1.39, [95%CL0.42–4.63], P < 0.01), ethnicities (OR = 0.88, [95%CL 0.79–0.98], P = 0.78), gestational age (OR = 1.5, [95%CL1.34–1.68], P = 0.65)were identified as risk factors for thrombosis. Conclusions This meta-analysis suggests that CVC, Surgery, mechanical ventilation, Infection/sepsis, gestational age, Respiratory distress, and different ethnicities are risk factors for thrombosis in children and neonates in ICU. These findings may help clinicians to identify high-risk patients and develop appropriate prevention strategies. Trial registration PROSPERO (CRD 42022333449).

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Section: Introductionmentioning

confidence: 99%