Neonatal cholestasis with ductal paucity and steatosis

Khanna, Rajeev; Alam, Seema; Rastogi, Archana; Sharma, Chhagan Bihari

doi:10.1007/s13312-013-0073-5

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Moreira et al [21] reported that only advanced fibrosis was significantly higher in the BA group than in other nonobstructive cholestasis, but early stages of portal fibrosis were comparable in both groups. Furthermore, portal fibrosis with early cirrhosis was found to be associated not only with BA but also with choledochal cyst, metabolic disorders, and some cases of PFIC [22].…”

Section: Discussionmentioning

confidence: 97%

Common misdiagnoses of biliary atresia

Sira¹,

Taha

Sira³

2014

European Journal of Gastroenterology &Amp; Hepatology

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Section: Discussionmentioning

confidence: 97%

Common misdiagnoses of biliary atresia

Sira¹,

Taha

Sira³

2014

European Journal of Gastroenterology &Amp; Hepatology

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“…the potential therapeutic 'golden window'. The recently published AARC score [32] is a good dynamic prognostic index to identify patients early and list them for LT.The most indication for liver transplantation in children is extra hepatic biliary atresia[33] with a failed Kasai operation, presenting as decompensated biliary cirrhosis with failure to thrive.…”

mentioning

confidence: 99%

Understanding the Basic Concepts of Liver Transplantation

Kedarisetty¹,

Kumar²,

Bhargav³

et al. 2020

Act Scie Gastro

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It has been more than 50 years since Prof Thomas Starzl and colleagues [1] performed the first successful human liver transplantation (LT) in the United States. In the following years, LT gradually established its role as definitive therapy for patients with acute liver failure and end-stage liver disease, and later on for selected patients with hepatocellular carcinoma (HCC). Over this period, rapid advances have taken place in pre-operative management of these critically ill liver diseases patients, sophisticated operative techniques, implementation of optimal post-transplant immunosuppressive regimens to balance between adequate immunosuppression to prevent rejection and not too much to cause infection. For a successful outcome in LT, it needs a multidisciplinary approach with a hepatologist, liver transplant surgeon and liver intensivist who serve as pillars of the program and ably supported by allied specialities like cardiology, pulmonology, nephrology, infectious diseases, transfusion medicine, radiology and so on. Timely transplant is the key to success, failing which patients do end up becoming too sick and are not in a fit state for LT. Hence it is important to understand that referral for liver transplant should be considered at the onset of decompensation and not just based on MELD criteria alone due to long waiting list especially in a cadaveric transplant setting. It is prudent to identify these patients of end stage liver disease (ESLD) early, triage patients needing LT, optimize them medically prior to transplant, establish standard working protocols for posttransplant and long-term immunosuppression with careful tailoring of immunosuppression, keeping strict vigilance on possible post-transplant metabolic complications at any point of time. The goal of such a systematic and protocolised approach is to maximise good patient and graft outcomes in a replicable manner across the board amongst various centres in the world.

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