Neonatal Coccidioidomycosis in Premature Twins

Bacterial Sepsis and Meningitis

“…Neonatal infections in twins have been caused by group A streptococci (case report of streptococcal sepsis in a mother and infant twins) [384], Salmonella species [385], Salmonella E. coli [384a], C. koseri (brain abscesses in twins) [156], malaria [386,387], coccidioidomycosis [388], cytomegalovirus infection [389][390][391], and rubella [392]. Neonatal infections in twins have been caused by group A streptococci (case report of streptococcal sepsis in a mother and infant twins) [384], Salmonella species [385], Salmonella E. coli [384a], C. koseri (brain abscesses in twins) [156], malaria [386,387], coccidioidomycosis [388], cytomegalovirus infection [389][390][391], and rubella [392].…”

A Quiescent Infection in a Premature Newborn

“…Neonatal infection was therefore suspected to be linked with the inhalation of maternal vaginal secretions infected with Coccidioides. 6,7,9-11…”

“…Neonatal infection was therefore suspected to be linked with the inhalation of maternal vaginal secretions infected with Coccidioides. 6,7,[9][10][11] To date, there is only one case report of congenital coccidioidomycosis in a neonate born via cesarean section. 12 The infant presented with classic symptoms, including respiratory distress and fevers, in the first 2 weeks of life.…”

Coccidioidomycosis in pregnancy: Case report and literature review of associated placental lesions

“…immitis [20] , [21] , [22] . The question regarding the transplacental passage of the spherules is controversial [23] , [24] , [25] , [26] . The spherules were found in the placenta ( Table 1 ) and documented to destroy the villi, however sporules were not found in fetal circulation [20] .…”

“… Fatal Wyoming, Colorado C . Imittis [23] N/A Third trimester N/A N/A N/A N/A Placentas were infected with coccidioidomycosis in all 6 cases of maternal death Fatal N/A N/A [24] 34 Preterm birth During pregnancy NR NR Twins; one died at age 11 days, the other died at age 21 days No lesions Fatal Riverside, CA NR [25] 34 At term During pregnancy NR NR Healthy infant, titer 1:4 No granulomas Reported with 4 cases of maternal death Kern County, CA NR [26] 20 16 weeks During pregnancy 1:128 NR Delivered by postmortem C-section, death after 10 h Marked focal acute and chronic granulomatous inflammation containing spherules and endospores Coccidioides immitis . Fatal Arizona C .…”