Neonatal congenital hyperinsulinism in Indonesia

Arimbawa, I Made; Satriawibawa, I Wayan Eka; Ariyanta, Kadek Deddy; Darmajaya, I Made; Anandasari, Pande Putu Yuli; Maker, Luh Putu Iin Indrayani

doi:10.1016/j.epsc.2020.101731

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Introductionmentioning

confidence: 99%

“…4 In this situation, it is assumed that intermittent maternal hyperglycemia leads to fetal hyperglycemia leading to hypertrophy and elevated function of pancreatic beta cells leading to embryonic and neonatal hyperinsulinemia. 5,6 Up to 15% of term infants experience more severe or persistent hypoglycemia that can be associated with long-term brain damage and neurodevelopmental delays. 7 The essential treatment of transient hyperinsulinemia includes intravenous dextrose, diazoxide, and proper nutrition.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism

Boskabadi

Ramezaninejad

Sohrab

et al. 2023

Clin Med Insights Case Rep

View full text Add to dashboard Cite

Diazoxide is one of the FDA-approved pharmacologic treatments for hyperinsulinemic hypoglycemia, however, its adverse effects in infants are not well described. We reported a 37-week-old boy with the diagnosis of hypoglycemia. We started a dextrose infusion, but we used oral diazoxide, due to hypoglycemia episodes despite the increase in dextrose intake. The newborn had a normoglycemic condition after gradually increasing the diazoxide dose to 15 mg/kg/day. He was fully breastfed and discharged at 14 days of age with ongoing diazoxide. In weekly serial clinical follow-ups, the parents noticed an increase in the growth of forehead and facial hair that was diagnosed as diazoxide-induced hypertrichosis. Diazoxide was gradually tapered, and hypertrichosis continued until 1 month after dioxide discontinuation. Diazoxide use in NICU settings has increased over time. Diazoxide has many side effects, one of which is hypertrichosis. Many diazoxide side effects have been reported in adults or children and few studies have reported the prevalence of these adverse effects of diazoxide in neonates and infants.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism

Boskabadi

Ramezaninejad

Sohrab

et al. 2023

Clin Med Insights Case Rep

View full text Add to dashboard Cite

show abstract

Challenges in the management of hyperinsulinemic hypoglycemia in a preterm neonate - A case report and literature review

Sachin,

Balakrishnan,

Amboiram

et al. 2023

JPED

View full text Add to dashboard Cite

Hyperinsulinemic hypoglycemia (HH) includes a diverse group of disorders characterized by dysregulated insulin secretion, exhibiting clinical, genetic, and morphological heterogeneity. It is associated with permanent brain damage. Hence, a timely diagnosis and prompt management are essential to safeguard against complications such as epilepsy, cerebral palsy, and neurodevelopmental deficits. We report the challenges faced in the management of HH in a preterm neonate. A baby girl was born to a G2A1 mother at 31 weeks of gestation due to preterm onset of labor with premature rupture of membranes. The baby had persistent and refractory hypoglycemia requiring oral and parenteral medications such as diazoxide, hydrochlorothiazide, hydrocortisone, nifedipine, glucagon infusion, and subcutaneous octreotide. Genetic testing unveiled a homozygous pathogenic mutation of the ABCC8 gene with autosomal recessive (AR) inheritance. As the AR inheritance always presents with diffuse lesions, a 18F-fluoro-dihydroxyphenylalanine positron emission computed tomography (18F-DOPA PET) scan was not done to differentiate focal and diffuse lesions. The baby underwent laparoscopic near-total pancreatectomy and was discharged on subcutaneous octreotide. Continuous intravenous glucagon infusion may help reduce the infusion rate of glucose needed to maintain normoglycemia. Diazoxide unresponsiveness in a baby with HH needs genetic studies. AR inheritance always presents as diffuse lesions. Hence, an 18F-DOPA PET scan can be deferred to differentiate the diffuse and focal forms.

show abstract

Neonatal congenital hyperinsulinism in Indonesia

Cited by 2 publications

References 14 publications

Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism

Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism

Challenges in the management of hyperinsulinemic hypoglycemia in a preterm neonate - A case report and literature review

Contact Info

Product

Resources

About