Neonatal Encephalopathy Following Fetal Distress

Sarnat, Harvey B.; Sarnat, Margaret S.

doi:10.1097/00006254-197705000-00011

Cited by 233 publications

(226 citation statements)

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“…Our study for mean values of biochemical parameters with severity of birth asphyxia is similar to the findings observed by Mukesh Choudhry et al, [8] Karlsson M, WibergItzel E et al, [32] Tariqul I, Seikh AH et al in 2010 [33] and Chaitali et al in 2016. [34] Mortality was more in severe degree of asphyxia as compared to mild and moderate variety and it was statistically significant (p < 0.01).…”

Section: Discussionsupporting

confidence: 90%

“…The present study showed that the increased level of serum ALT, AST, hypoalbuminaemia and prolonged prothrombin time were associated more with death groups (69%, 66%, 55, 69%, 79%) as compared to survival group (42%, 44%, 50.4%, 44%, 43%) and they were statistically significant as 'p' value was < 0.001 (Table No. 8). This study is similar to the findings observed by Mukesh Choudhary, [7] Tariqul I et al [33] and Chaitali Patra et al [34] The Table 9 depicts that 2 babies from HIE-2 group died, one within 1 -3 days and the other one within 4 -7 days.…”

Section: Discussionsupporting

confidence: 90%

“…The study cohort consisted of the hospitalised term neonates of birth weight ≥ 2.5 kg to the indoors/ S.N.C.U of S.C.B M.C.H and S.V.P.P.G.I.P, Cuttack with diagnosis of birth asphyxia as per the following defined criteria. [7,8,9] Inclusion Criteria Apgar score < 7 at 5 minutes of birth, 2. Delayed onset of respiration for ≥ 5 minutes, 3.…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were collected at the time of maximum Sarnat and Sarnat stage, [8] and sent for investigations. Following investigations were done in Department of Pathology and Biochemistry.…”

Section: Investigationsmentioning

confidence: 99%

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A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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BACKGROUND Perinatal asphyxia can lead to hypoxic ischaemic encephalopathy (HIE). The mortality due to hypoxic ischaemic encephalopathy is as high as 28.8% and morbidity is 30% of surviving newborn due to hypoxic ischaemic encephalopathy. Aims and Objectives-To study the plasma biochemical phenomena in neonates with hypoxic ischaemic encephalopathy in relation with severity of HIE. MATERIALS AND METHODSIt is a hospital-based prospective study done in tertiary care hospital in SCB Medical College Hospital and SVP PG Institute, Cuttack from November 2015 to October 2017. RESULTSThe babies with perinatal asphyxia develop hyponatraemia, hypocalcaemia, hyperkalaemia, high serum urea and creatinine, high serum ALT, AST, ALP, decrease in serum albumin and increase in Prothrombin time in proportion to the severity of asphyxia. CONCLUSIONA significant number of babies with birth asphyxia and deranged biochemical parameters either died or discharged with severe neurological sequelae. It can be concluded that deranged biochemical parameters are early indicators of poor outcome. Studies should be held on the effects of early correction of these metabolic derangements with their outcomes, so that it may invent a new horizon of treatment for birth asphyxia babies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

See 2 more Smart Citations

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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show abstract

“…Infants with encephalopathy were defined as term babies (≥ 37 weeks) who in the first week of life developed either seizures alone or any two of the following lasting for more than 24 hours: abnormal consciousness, abnormal tone, poor feeding of presumed central origin, and/or an inability to initiate or maintain respiration, also of presumed central origin (Nelson and Leviton 1991). Encephalopathy was graded as moderate or severe according to criteria modified from Sarnat and Sarnat (1976). Infants defined as having severe encephalopathy were those who fulfilled one or more of the following criteria: ventilation for more than 24 hours, treatment with two or more anticonvulsants, comatose or stuporous state, or death in the neonatal period.…”

Section: Methodsmentioning

confidence: 99%

Birth defects in children with newborn encephalopathy

Felix

Badawi

Kurinczuk

et al. 2000

Develop Med Child Neuro

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This study was designed to investigate birth defects found in association with newborn encephalopathy. All possible birth defects were ascertained in a population‐based study of 276 term infants with moderate or severe encephalopathy and 564 unmatched term control infants. A strong association between birth defects and newborn encephalopathy was found with defects affecting 27.5% of children with encephalopathy and 4.3% of control children (odds ratio 8.55; 95% confidence interval 5.25 to 13.91; p<0.001). In 11.8% of infants with a birth defect the defect was not diagnosed until after the newborn period, illustrating one of the difficulties in attempting to exclude infants with birth defects from studies of newborn encephalopathy. The majority of defects (89%) were not specific anomalies of the CNS. In 36.8% of children with encephalopthy who had a birth defect, the defect was considered to be the probable cause of the encephalopathy. Infants with birth defects who had encephalopathy had a poorer prognosis than those without: they were twice as likely to die by the age of 2 years and three times more likely to have cerebral palsy. This study catalogues the spectrum of birth defects associated with newborn encephalopathy and illustrates the importance of their inclusion when investigating both the aetiology and outcome of this condition.

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