Neonatal exposure to aluminum chloride disrupts branching morphogenesis and hormonal signaling of the ventral male prostate and female prostate of gerbils

Gomes, Liana da Silva; Lima, Danilo da Silva; Costa, Janaina Ribeiro; Silva, Cínthia Rio Branco da; Marques, Mirian David; Brito, Pedro Vale de Azevedo; Biancardi, Manoel F.; Taboga, Sebastião Roberto; Ghedini, Paulo César; Santos, Fernanda C. A.

doi:10.1016/j.jtemb.2020.126559

Cited by 6 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in gerbils subjected to different experimental conditions, 38,39 but this is the first study to demonstrate that part of Al toxic effects persist up to 30 days after the glandular damage, especially in females.…”

Section: Discussionmentioning

confidence: 83%

“…[35][36][37] Previous studies with gerbils have shown that Al exposure during neonatal development alters prostate branching morphogenesis. 38 Additionally, Da Silva Lima et al 39 observed that adult gerbils exposed to Al had tissue damage in the prostate and gonads, as well as reduced activity of the antioxidant protection system in these organs. However, further studies are needed to elucidate the Al effects, especially to assess the persistence and longevity of its activity on the reproductive organs such as the prostate.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

Lima

Gomes

Figueredo

et al. 2021

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Aluminum (Al) is a widespread metal in the environment, and is found in fresh or processed foods, household utensils, packaging, and medicines. In addition to its high toxicity, Al can also have estrogenic agonistic effects on target organs. Considering that the Al effects on the prostate are little known, the aim of this study was to evaluate the impact of aluminum chloride (AlCl 3 ) subacute exposure on the morphophysiology of the male ventral prostate and the female prostate of adult gerbils. Furthermore, the glandular restoration capacity in face of the Al insults was evaluated in gerbils that were submitted to 30 days of recovery. Male and female gerbils were orally exposed to AlCl 3 (10 mg/kg) for 30 consecutive days. The animals were euthanized 1 day (Al1D) or 30 days (Al30D) after the end of treatment. Prostates were dissected out and processed for structural, ultrastructural and immunohistochemical analyses. Male ventral prostates and female prostates of the Al1D group showed increased cell proliferation, glandular hyperplasia, increased secretory activity and greater androgen receptor immunoreactivity. In males, Al withdrawal (Al30D) allowed a partial recovery of the prostate, as the glandular secretory activity, and frequency of androgen receptor positive cells were similar to the control group. In females, the recuperation interval (Al30D) was not enough to restore the prostatic morphology, since the gland remained hyperplastic, proliferative, and with greater androgen and estrogen receptor immunoreactivity. These data alert to the importance of avoiding Al exposure, since this metal can have a harmful and prolonged action on the prostate.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

Lima

Gomes

Figueredo

et al. 2021

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is suggested that weight loss may be related to the Al ability to compete with essential cations for organ development. Gomes et al (2020) demonstrated that male gerbils neonatally exposed to Al showed a reduction in body weight at 15 days of age. However, in the present study, male and female gerbils exposed to Al during neonatal development showed body weight gain during aging.…”

Section: Discussionmentioning

confidence: 99%

“…Neonates and children are susceptible to Al toxicity as they are frequently exposed to milk formulas and vaccines (Keith et al, 2002; Quigley et al, 2019). In this context, a recent study by our research group showed that Al neonatal exposure impaired the prostate development pattern in 15‐day‐old gerbils (Gomes et al, 2020). Furthermore, Al subacute exposure during adulthood also caused tissue insult and oxidative stress in the prostate of male and female gerbils (Silva Lima et al, 2020, 2022).…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia

Gomes

Lima

Costa

et al. 2023

Cell Biology International

Self Cite

View full text Add to dashboard Cite

Several pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging.

show abstract

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Leonel

Ruiz

Bedolo

et al. 2021

Cell Biology International

Self Cite

View full text Add to dashboard Cite

The mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17‐β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho‐STAT3 (P‐STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor‐α, COX‐2, P‐STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG.

show abstract

Neonatal exposure to aluminum chloride disrupts branching morphogenesis and hormonal signaling of the ventral male prostate and female prostate of gerbils

Cited by 6 publications

References 50 publications

Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Contact Info

Product

Resources

About