Neonatal Giant Congenital Nevi With Proliferative Nodules

Leech, Suzy; Bell, Hazel Κ.; Leonard, Niamh; Jones, Sue Lewis; Geurin, Deirdre; McKee, Peter; Lawrence, C.M.

doi:10.1001/archderm.140.1.83

Cited by 107 publications

(28 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Giam et al(1) proposed two possible hypotheses to explain the erosive skin changes seen in 10 patients with congenital melanocytic nevi: 1) melanocytes in the nevi possibly secrete a factor that affects the formation of basement membrane components with subsequent skin fragility; 2) there is weakening of the attachment of the basement membrane to the papillary dermis secondary to the proliferation of nevic cells at the dermal-epidermal junction. (1, 16, 17) The latter hypothesis corresponds most with our case.…”

Section: Discussionsupporting

confidence: 90%

“…Proliferative nodules show a wide spectrum of changes including findings sometimes overlapping with those found in malignant melanoma. (17, 18)…”

Section: Discussionmentioning

confidence: 99%

“…(15, 20) Malignant melanoma should be suspected when there are large zones of necrosis, extremely atypical melanocytes, and numerous mitoses. (17, 18)…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma

Lazova

Yang

Habr

et al. 2017

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Histopathological interpretation of proliferative nodules occurring in association with congenital melanocytic nevi can be very challenging due to their similarities with congenital malignant melanoma and malignant melanoma arising in association with congenital nevi. We hereby report a diagnostically challenging case of congenital melanocytic nevus with proliferative nodules and ulcerations, which was originally misdiagnosed as congenital malignant melanoma. A subsequent histopathological examination in consultation by one of the authors (RL) and Mass Spectrometry Imaging analysis rendered a diagnosis of congenital melanocytic nevus with proliferative nodules. In this case, Mass Spectrometry Imaging, a novel method capable of distinguishing benign from malignant melanocytic lesions on a proteomic level, was instrumental in making the diagnosis of a benign nevus. We emphasize the importance of this method as an ancillary tool in the diagnosis of difficult melanocytic lesions.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Proliferative nodules show a wide spectrum of changes including findings sometimes overlapping with those found in malignant melanoma. (17, 18)…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma

Lazova

Yang

Habr

et al. 2017

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…The changes in nevi morphology produced by PNs can be subtle making difficult to identify them in a bare eye examination, thus dermoscopic examination and follow-up has a key value to diagnose this entity. 2,3 Their etiology is unclear; it is hypothesized that they are a monoclonal proliferation of melanocytic cells. 4 Generally PNs exhibit a darker pigmentation compared with the nevus of origin and usually have the same texture.…”

Section: Discussionmentioning

confidence: 99%

Proliferative nodule in melanocytic nevi mimicking deep penetrating nevus

Almódovar-Real

Molina-Leyva

Aneiros‐Fernández

2017

An. Bras. Dermatol.

View full text Add to dashboard Cite

Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.

show abstract

“…4 O risco de transformação maligna nos NMCs, de modo geral, varia de 5% a 40% 1 e de 4,5% a 10%. 5 A revisão da literatura mostra muitas controvérsias em relação ao risco em NMCs grandes/gigantes (1%-42%), 6,7 médios (3%-21%) 1,8 e pequenos (8,1%-14,9%).…”

Section: Introductionunclassified

Estudo clínico dos nevos melanocíticos congênitos na criança e no adolescente

Fernandes

Machado²

2009

An. Bras. Dermatol.

View full text Add to dashboard Cite

Resumo: FUNDAMENTOS: a classificação dos nevos melanocíticos congênitos (NMC) e a magnitude do risco de transformação em melanoma são ainda polêmicos. OBJETIVOS: Analisar o perfil dos NMC em crianças e adolescentes no IPPMG-UFRJ segundo sexo, cor, idade, tipo clínico, localização e evolução. MATERIAL E MÉTODOS: Estudo longitudinal de coorte retrospectivo e prospectivo de 1994 a 2007; amostra de demanda espontânea e referida. RESULTADOS: 30 crianças e 30 adolescentes apresentaram 74 NMC: 60,8% (pequenos), 27% (médios), 5,4% (grandes) e 6,7% (gigantes), sendo que 45,9% no sexo masculino e 54% no sexo feminino e 45,9% em brancos e 54,% em não brancos. Sexo e cor não influenciaram o tipo clínico. Dentre os pequenos e médios, 27,1% apresentaram-se no tórax e 23% na cabeça e pescoço; os grandes e gigantes no pólo cefálico, região cervical, linha média posterior e membros; 28,3% foram seguidos por mais de 10 anos, 47,3% entre três e nove anos e 24,3% por tempo inferior a três anos. Os NMC pequenos e médios se mantiveram inalterados; um grande e dois gigantes mostraram clareamento; nenhum caso desenvolveu melanoma. CONCLUSÃO: distribuição homogênea entre brancos/não brancos e sexo masculino/ feminino. O sexo e a cor não tiveram relação com o tipo clínico; os NMC pequenos predominaram com localização preferencial no tronco. Palavras-chave: Adolescente; Criança; Melanoma; Nevo pigmentado Abstract: BACKGROUND: The classification of the congenital melanocytic nevus (CMN) and the magnitude of the risk of transformation into melanoma are still controversal. OBJECTIVE: To analyse the profile of the CMN in the child and teenager at IPPMG-UFRJ according to sex, skin colour, age, clinical type, locations and evolution. METHODS: Longitudinal study of retrospective and prospective cohort from 1994 to 2007. Aleatoric sample from spontaneous or referal demand. Results: 30 children and 30 teenagers showed 74 nevi: 60,8% (small), 27% (medium), 5,4% (large) and 6,7% (giant); from these, 45,9% were in the male sex and 54% in the female sex. There were 45,9% in white and 54% in non-white. Sex and skin colour didn't influence the clinical type. Among the small and medium nevi, 27,1% were located in the trunk, 23% in the head and neck; the large and giant ones in the head, neck, back and limbs; 28,3% were attended for more than 10 years, 47,3% between three and nine years and 24,4% for a time below three years; the small and medium CMN kept unchanged. The fading of the lesion was observed in one large and in two giant CMN. No cases of melanoma were observed. CONCLUSION: An homogeneous distribution among white/non white and male/female; the sex and the ethnic group did not influence the clinical type; the small CMN was the most frequent clinical type mainly in the trunk.

show abstract

Neonatal Giant Congenital Nevi With Proliferative Nodules

Cited by 107 publications

References 24 publications

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma

Proliferative nodule in melanocytic nevi mimicking deep penetrating nevus

Estudo clínico dos nevos melanocíticos congênitos na criança e no adolescente

Contact Info

Product

Resources

About