Neonatal Graves' Disease

McKenzie, J. M.

doi:10.1210/jcem-24-7-660

Cited by 133 publications

(42 citation statements)

References 14 publications

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“…Graves' disease is associated with functional changes and little in the way of specific pathology, except for hyperplasia and lymphocytic infiltration of the thyroid gland and edema, metachromasia, and lymphocytic infiltration of retroorbital tissues (24). It (25,26). One can conclude that the hypothesis that Graves' disease is caused by autoallergy is not an improbable one, although it is far from established at the present time.…”

mentioning

confidence: 84%

Inhibition of long-acting thyroid stimulator by thyroid particulate fractions.

Beall¹,

Solomon²

1966

J. Clin. Invest.

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confidence: 84%

Inhibition of long-acting thyroid stimulator by thyroid particulate fractions.

Beall¹,

Solomon²

1966

J. Clin. Invest.

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“…There are several reports of LATS crossing the placenta (McKenzie, 1964;Sunshine et al, 1965), which are compatible with LATS being an antibody. Further, gamma globulin antibody having thyroid stimulating activity is produced by immunization of rabbits with human thyroid cell fraction (Beall and Solomon, 1968;McKenzie, 1968).…”

mentioning

confidence: 84%

Comparative Studies on the Properties of LATS and TSH

Ochi

DeGroot

1970

Endocrinol Japon

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LATS activity was neutralized by pretreatment of mice with anti-IgG in vivo. Simultaneous injection of epsilon-amino caproic acid and hydrocortisone does not inhibit LATS action. Human thyroid-microsomal fractions neutralize LATS activity and TSH activity. The decrease in activity of LATS and TSH caused by thyroid microsomes correlates positively. Calf thyroid microsomes are much less active than human thyroid microsomes in absorbing LATS activity. Deoxycholate and sonification solubilize the LATS neutralizing activity. No visible precipitate formed between these solubilized fraction and LATS-IgG, using the Ouchterlony agar diffusion method. LATS did not differ from TSH in heat stability, and partially heat denatured LATS still had a long acting type response. Dissociation of a small rapidly acting molecule from LATS could not be obtained in high molar NaCI solution. LATS-IgG fragments digested by proteolytic enzymes (papain, pepsin, trypsin, and ficin) had a prolonged response like LATS. However, these fragments, in the presence of cysteine, either gave the same response after 2 hr and 8 hr, or gave a short acting response like TSH. The thyroid stimulating active site of the LATS active gamma globulin may be situated in Fab or Fab fragments having the antibody combining site. LATS did not stimulate the chicken thyroid, although TSH had this action. The proteolytic fractions of LATS-IgG also did not stimulate the chicken thyroid. No increase of gammaglobulin and/or IgG was found in some sera with a high LATS activity. Binding of LATS-IgG to mouse or human thyroid could not be visualized using the Coon's immunofluorescent method. These data support the concept that LATS is an IgG having a high specific activity of thyroid stimulating action.

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“…It is widely accepted that serum TBII and TSAb pass through the placenta and develop neonatal Graves' disease [15,16]. Graves' disease is usually rather improved by pregnancy [6,17] and deteriorates in the postpartum period [17,18].…”

Section: Case Reportmentioning

confidence: 99%

Triphasic Changes in Thyroid Function in a Patient with Primary Hypothyroidism in the Course of Pregnancy and the Early Post-Partum Period.

1997

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Abstract.We report a rare case of primary hypothyroidism in which thyroid function was changed from hypothyroidism to hyperthyroidism in the course of pregnancy and finally returned to hypothyroidism in the early post-partum period.She delivered an infant with neonatal Graves' thyrotoxicosis. Serum thyroid-stimulating antibodies (TSAb) and thyroid stimulating-blocking antibodies (TSBAb) coexisted in these patients.The triphasic changes in thyroid function may be explained by altered balance between TSAb and TSBAb in relation to pregnancy and delivery in the present case, although cellular immunity could be independently involved in atrophic changes in the postpartum period.

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Neonatal Graves' Disease

Cited by 133 publications

References 14 publications

Inhibition of long-acting thyroid stimulator by thyroid particulate fractions.

Inhibition of long-acting thyroid stimulator by thyroid particulate fractions.

Comparative Studies on the Properties of LATS and TSH

Triphasic Changes in Thyroid Function in a Patient with Primary Hypothyroidism in the Course of Pregnancy and the Early Post-Partum Period.

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