Neonatal handling reduces angiotensin II receptor density in the medial preoptic area and paraventricular nucleus but not in arcuate nucleus and locus coeruleus of female rats

Gomes, Cláudio; Donadio, Márcio Vinı́cius Fagundes; Franskoviaki, I.; Anselmo-Franci, Janete Aparecida; Franci, Celso Rodrigues; Lucion, Aldo Bolten; Sanvitto, Gilberto Luiz

doi:10.1016/j.brainres.2005.10.081

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Besides the decreased response to a novel environment, neonatal handling also affects the reproductive function in female rats, evidenced by decreased ovulation, plasma levels of estradiol, luteinizing hormone, follicle-stimulating hormone and prolactin [4][5][6] . Indeed, stable structural changes such as decreased number of cells in the locus coeruleus of neonatally handled rats [7] and decreased density of the angiotensin II (Ang II) receptors in the medial preoptic area and hypothalamic paraventricular nucleus were also demonstrated [8] . The perinatal period is crucial for many system developments, including kidney and urinary tract.…”

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Neonatal Handling Reduces Renal Function in Adult Rats

Donadio

Jacobs²,

Corezola³

et al. 2009

Kidney Blood Press Res

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Background/Aims: To evaluate the effects of neonatal handling on hydroelectrolytic balance in adult rats. Methods: The litters were divided into two groups: nonhandled and handled. The procedure consisted of handling the pups for 1 min/day in the first 10 days postnatally. When adults, animals had their body weight verified and were housed in individual metabolic cages. After a 24-hour period, urine samples were collected and the urinary and water intake volumes measured. Blood samples to determine osmolality, aldosterone, corticosterone, angiotensin II, creatinine, urea, sodium and potassium levels were collected. The kidneys were removed for histological assessment. Urinary osmolality, sodium, urea and creatinine were also measured and the creatinine clearance (CC) calculated. Results: No difference between groups was found in the body weight. Handled animals showed a reduction in the total kidney wet weight, water intake, urinary volume, CC, plasma angiotensin II, corticosterone and aldosterone when compared to the nonhandled and an increase in the urinary osmolality and sodium excretion fraction. No differences in serum potassium and no evidence of structural changes were demonstrated by histological analysis. Conclusion: Neonatal handling induced long-lasting effects decreasing renal function without evidence of kidney structural changes.

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confidence: 99%

Neonatal Handling Reduces Renal Function in Adult Rats

Donadio

Jacobs²,

Corezola³

et al. 2009

Kidney Blood Press Res

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“…A utilização de modelos animais tem fornecido informações relevantes sobre os possíveis mecanismos pelos quais eventos adversos precoces alteram de forma duradoura a resposta emocional. Fatores ambientais presentes durante o início da vida de roedores, como o manuseio (Beane et al, 2002;Gomes et al, 2006) e desnutrição (Lesage et al, 2006;Levay et al, 2010), alteram a função de estruturas relacionadas à resposta ao estresse. No entanto, nas pesquisas pré-clínicas, o evento estressante melhor caracterizado tem sido a separação materna (Lehmann e Feldon, 2000;Imanaka et al, 2006;Millstein e Holmes, 2007).…”

Section: Infecção Como Evento De Estresse Precoceunclassified

Efeito da inoculação de lipopolissacarídeo em ratos recém-nascidos sobre o comportamento exploratório na adolescência

Rodríguez¹

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AgradecimentosAo meu orientador Silvio Morato, pela confiança e apoio depositado no meu trabalho, pela contribuição na minha formação profissional e pessoal, por sua amizade ao longo de todos esses anos, meus sinceros agradecimentos.Aos membros da banca de qualificação, Dra. Janaína Zanoveli, Prof. Dr. Ricardo Luiz Nunes de Souza, Prof. Dr. Francisco Juarez Ramalho Pinto, pelas importantes sugestões para o enriquecimento desse trabalho. À banca examinadora, pela atenção dispensada na leitura da dissertação.Ao Prof. Dr. Francisco Juarez Ramalho Pinto, pelas importantes discussões e ideias no decorrer do desenvolvimento desse estudo, por sua amizade. À Denise Brufato Ferraz, pela sua contribuição técnica na elaboração desse trabalho, e por sua amizade. À Renata Beatriz Vicentini, pela grande ajuda, paciência e amizade durante todos esses anos.A todos os que de alguma forma contribuíram na realização deste trabalho, aos funcionários do programa pela ajuda. À Inês, Denise, Sônia... Aos amigos de laboratório, Thiago, Carol, Julián e Paulinho.Aos meus grandes amigos Julián, Aninha e Milena e a todos os amigos colombianos.

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Evaluation of the brain and kidney renin‐angiotensin system and oxidative stress in neonatal handled rats

Rodriguez

Mesquita

Attolini

et al. 2011

Developmental Psychobiology

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The aim of this study was to test the hypothesis that the renin-angiotensin system (RAS) components, as well as the oxidative stress system, would respond to early environmental changes. Thus, we have evaluated the effects of neonatal handling on both brain and kidney RAS and oxidative stress. Pups were divided into two groups: nonhandled and handled. The procedure consisted of handling them for 1 min/day in the first 10 days of life. On days 1, 5, and 10, animals were killed by decapitation. Blood samples were collected and the brain and kidneys were removed. Renin, AT(1), and AT(2) mRNA expression were evaluated through RT-PCR. Angiotensin II (ANG II) serum concentration was also measured. An increased ANG II concentration, brain and kidney AT(2) mRNA expression were demonstrated. The kidney mRNA AT(1) expression was decreased. There was also a kidney lipid peroxidation increase and a brain superoxide dismutase and catalase decrease. In conclusion, handling in the neonatal period induces the activation of the angiotensinergic system, as well as modulates its mRNA receptor expression. The oxidative stress balance system seems not to be involved.

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Neonatal handling reduces angiotensin II receptor density in the medial preoptic area and paraventricular nucleus but not in arcuate nucleus and locus coeruleus of female rats

Cited by 3 publications

References 21 publications

Neonatal Handling Reduces Renal Function in Adult Rats

Neonatal Handling Reduces Renal Function in Adult Rats

Efeito da inoculação de lipopolissacarídeo em ratos recém-nascidos sobre o comportamento exploratório na adolescência

Evaluation of the brain and kidney renin‐angiotensin system and oxidative stress in neonatal handled rats

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