Neonatal hydrocephalus in the offspring of rats fed during pregnancy non-toxic amounts of tellurium

Garro, Frank; Pentschew, A.

doi:10.1007/bf00940754

Cited by 42 publications

(5 citation statements)

References 8 publications

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“…Several investigators have reported [12][13][14]16 that weanling rats fed a Te diet exhibit paralysis of the hind limbs, which is attributed to segmental demyelination of the axons in the sciatic nerve. Te produces demyelination via metabolic alteration in the myelinating Schwann cells, 17 rather than direct damage to the myelin sheath.…”

Section: Experimental Model Of Demyelinationmentioning

confidence: 98%

MR properties of excised neural tissue following experimentally induced demyelination

et al. 2005

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Changes in the magnetic resonance (MR) parameters of demyelinated neural tissue were measured in vitro using an experimental animal model. A tellurium (Te) diet was applied to weanling rats to induce the demyelination process in the sciatic nerve. The quantitative MR parameters, such as T(1), T(2) relaxation time constants and magnetization transfer (MT) were measured each day after applying the Te diet (up to 7 days) and were found to be substantially different from those of normal nerves. An increase in the average T(1) and T(2) was observed along with a decrease in the MT ratio (MTR) and the quantitative MT parameter M(0B), which describes the semisolid pool of protons. Most of the MR parameters correlated very well with the myelin fraction of neural tissue evaluated by quantitative histopathology. The T(2) relaxation spectrum provided the most efficient quantitative assessment of changes in neural tissue microstructure and its analysis resulted in a powerful tool to distinguish the processes of demyelination and inflammation. In comparison, the MT measurements were less successful.

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Section: Experimental Model Of Demyelinationmentioning

confidence: 98%

MR properties of excised neural tissue following experimentally induced demyelination

et al. 2005

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“…67 Tellurium is known to pass the blood-brain barrier and can accumulate in nerve cells. 68 Rabbits injected with tellurium developed dark grey discoloration of the brain after prolonged administration. 68 Injection of tellurium in rats, led to hydrocephalus in their offspring.…”

Section: General Information By Chemical Classmentioning

confidence: 99%

Biological and environmental interactions of emerging two-dimensional nanomaterials

Wang¹,

Zhu²,

Qiu³

et al. 2016

Chem. Soc. Rev.

240

210

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Two-dimensional materials have become a major focus in materials chemistry research worldwide with substantial efforts centered on synthesis, property characterization, and technological application. These high-aspect ratio sheet-like solids come in a wide array of chemical compositions, crystal phases, and physical forms, and are anticipated to enable a host of future technologies in areas that include electronics, sensors, coatings, barriers, energy storage and conversion, and biomedicine. A parallel effort has begun to understand the biological and environmental interactions of synthetic nanosheets, both to enable the biomedical developments and to ensure human health and safety for all application fields. This review covers the most recent literature on the biological responses to 2D materials and also draws from older literature on natural lamellar minerals to provide additional insight into the essential chemical behaviors. The article proposes a framework for more systematic investigation of biological behavior in the future, rooted in fundamental materials chemistry and physics. That framework considers three fundamental interaction modes: (i) chemical interactions and phase transformations, (ii) electronic and surface redox interactions, and (iii) physical and mechanical interactions that are unique to near-atomically-thin, high-aspect-ratio solids. Two-dimensional materials are shown to exhibit a wide range of behaviors, which reflect the diversity in their chemical compositions, and many are expected to undergo reactive dissolution processes that will be key to understanding their behaviors and interpreting biological response data. The review concludes with a series of recommendations for high-priority research subtopics at the “bio-nanosheet” interface that we hope will enable safe and successful development of technologies related to two-dimensional nanomaterials.

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“…Pregnant rats fed high dietary concentrations of elemental tellurium (Te) give birth to pups with hydrocephalus (Garro and Pentshew 1964;Duckett 1971 enlarged ventricles, but significant microscopic findings are confined to flattening of the ependyma and edema of the subependymal white matter. Hemorrhage is a contributing cause of death in animals throughout the 1st week of life and is presumably the result of elevated intracranial pressure (Garro and Pentschew 1964) although direct injury to the blood vessels by tellurium may also contribute. By day 5, the cerebral aqueduct has become stenotic, and there is microscopic evidence of cortical compression by the cerebrospinal fluid (Duckett 1971).…”

Section: Microscopic Featuresmentioning

confidence: 99%

Tellurium Poisoning, Rat

Reuhl¹

1988

Nervous System

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Neonatal hydrocephalus in the offspring of rats fed during pregnancy non-toxic amounts of tellurium

Cited by 42 publications

References 8 publications

MR properties of excised neural tissue following experimentally induced demyelination

MR properties of excised neural tissue following experimentally induced demyelination

Biological and environmental interactions of emerging two-dimensional nanomaterials

Tellurium Poisoning, Rat

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