Neonatal hypofunction of NMDA receptors alters perforant path synaptic plasticity, filtering and impairs dentate gyrus-mediated spatial discrimination
Luis Alfredo Márquez,
Carolina Lopez-Rubalcava,
Emilio Galvan
Abstract:Background and Purpose: Transient hypofunction of NMDARs represents a
convergence point for the onset and further development of psychiatric
disorders, including schizophrenia. Although the cumulative evidence
indicates dysregulation of the hippocampal formation in schizophrenia,
the integrity of the synaptic transmission and plasticity conveyed by
the somatosensorial inputs to the dentate gyrus, the perforant path
synapses, have barely been explored in this pathological condition.
Experimental Approach: We id… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.