Neonatal immune challenge alters reproductive development in the female rat

Sominsky, Luba; Meehan, Crystal L.; Walker, Adam K.; Bobrovskaya, Larisa; McLaughlin, Eileen A.; Hodgson, Deborah M.

doi:10.1016/j.yhbeh.2012.02.005

Cited by 52 publications

(57 citation statements)

References 86 publications

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“…Because maternal sickness behavior during lactation is also accompanied by maternal stress [52,53], exposure to LPS on LD3 may have affected the HPA axis in the offspring, which may be responsible for the changes observed herein [54]. A previous study reported a reduction of USVs in rat pups from dams exposed to LPS [50].…”

Section: Discussionmentioning

confidence: 98%

Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring

Nascimento

Alves

Massoco

et al. 2014

Neuroimmunomodulation

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Objective: The present study analyzed the effects of lipopolysaccharide (LPS) on maternal behavior during lactation and possible correlations with changes in emotional and immune responses in offspring. Methods: Lactating rats received 100 μg/kg LPS, and the control group received saline solution on lactation day (LD) 3. Maternal general activity and maternal behavior were observed on LD5 (i.e. the day that the peak of fever occurred). In male pups, hematological parameters and ultrasonic vocalizations (USVs) were assessed on LD5. At weaning, an additional dose of LPS (50 µg/kg, i.p.) was administered in male pups, and open-field behavior, oxidative burst and phagocytosis were evaluated. Results: A reduction in the time in which dams retrieved the pups was observed, whereas no effects on maternal aggressive behavior were found. On LD5, a reduction of the frequency of USVs was observed in pups, but no signs of inflammation were found. At weaning, an increase in immune system activity was observed, but no differences in open-field behavior were found. Conclusion: These results indicate that inflammation in lactating mothers disrupted mother/pup interactions and may have produced short- and long-term effects on pup behavior as well as biological pathways that modulate inflammatory responses to bacterial endotoxin challenge in pups.

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Section: Discussionmentioning

confidence: 98%

Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring

Nascimento

Alves

Massoco

et al. 2014

Neuroimmunomodulation

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“…The most pronounced effect occurs in female rats compared to males (CAMERON et al, 2008;WALKER et al, 2011;SOMINSKY et al, 2012).…”

Section: Introductionmentioning

confidence: 92%

“…In addition, neonatal LPS exposure did not affect the F1 generation fertility but higher mortality and morbidity were observed in litters born to LPS-treated mothers, suggesting that neonatal immunological challenge has a profound impact on the female reproductive development and its possible transferability to a subsequent generation (SOMINSKY et al, 2012).…”

Section: Introductionmentioning

confidence: 93%

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

Pimentel

Casati

Cirano

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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Substantial evidence suggests a direct link between periodontitis in pregnant women and subsequent adverse pregnancy outcomes. However, no studies have evaluated the transgenerational effects of periodontitis on the reproductive performance of subsequent generations. The present study investigated whether maternal periodontal disease exerts deleterious transgenerational effects on reproductive performance in F1 female rats. Rat female offspring from mothers that were subjected to experimentally induced periodontitis or sham operation were mated with sexually experienced male rats. The weight and reproductive performance of these F1 offspring were evaluated on gestation day 21, including maternal weight, litter weight, individual pup weight, number of pups, and number of resorptions. The percentage of dams with resorptions and the litter weight/number of pups were also calculated. Compared with the control group, an increase was observed in the percentage and number of resorptions and litter weight/number of pups, and a decrease was observed in the number of pups born in the experimental group. Maternal weight, litter weight, and individual pup weight were not different between the control and experimental groups. Maternal periodontitis impaired reproductive performance in the F1 generation. We showed that periodontitis may induce reproductive injury in adult offspring even if the offspring do not undergo any inflammatory/infectious process during their postnatal life or during gestation. These findings reinforce the importance of oral care during pregnancy. Keywords: Maternal immune activation. Reproduction. Intergenerational effect. Periodontitis. Rat. ResumoExistem evidências substanciais de uma relação direta entre periodontite em mulheres grávidas com efeitos adversos reprodutivos. No entanto, nenhum estudo avaliou os efeitos intergeracionais da periodontite sobre o desempenho reprodutivo das gerações subsequentes. O presente estudo investigou se a doença periodontal materna exerce efeitos intergeracionais deletérios sobre o desempenho reprodutivo em ratos fêmeas da geração F1. Assim, filhas de ratas cujas mães foram submetidas a periodontite experimental ou falsamente operadas foram acasaladas com ratos machos sexualmente experientes. O peso corporal e desempenho reprodutivo da geração F1 foram avaliados no dia 21 de gestação, incluindo o peso materno, peso da ninhada, peso da individual dos filhotes, número de filhotes e de reabsorções. A percentagem de fêmeas com reabsorção e o peso da ninhada/número de filhotes também foram calculados. Comparados com o grupo controle, observou-se aumento na porcentagem e número de reabsorções e no peso da ninhada/ número de filhotes, e decréscimo no número de filhotes nascidos no grupo experimental. O peso materno, peso da ninhada e individual dos filhotes não foi diferente entre o controle e experimental. Estes resultados mostram que a periodontite experimental materna prejudica o desempenho reprodutivo da geração F1, mesmo que estes animais não tenham sido expo...

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“…Immediate HPG responses to LPS administration on postnatal days 3 and 5 were observed in the neonatal period, whereby circulating testosterone and LH in males and LH in females were decreased [14]. In the same model, LH and FSH suppression was observed at puberty in females [13,14], and suppression of testosterone and LH surges was observed in both sexes during mating [14]. Similarly, LPS exposure during gestation induced a decline in circulating testosterone levels in pubertal male offspring [67].…”

Section: Impact Of Perinatal Lps Exposure On Reproductive Functionmentioning

confidence: 99%

“…Perinatal immune activation has been shown to affect reproductive physiology long term [12]. Of note is the finding that aberrant activation of the immune response during early development, triggered by a bacterial endotoxin, has been shown to alter the trajectory of sexual maturation and affect reproductive outcomes in adulthood [13,14,15,16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

Factors in Early-Life Programming of Reproductive Fitness

2015

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Fertility rates have been declining worldwide, with a growing number of young women suffering from infertility. Infectious and inflammatory diseases are important causes of infertility, and recent evidence points to the critical role of the early-life microbial environment in developmental programming of adult reproductive fitness. Our laboratory and others have demonstrated that acute exposure to an immunological challenge early in life has a profound and prolonged impact on male and female reproductive development. This review presents evidence that perinatal exposure to immunological challenge by a bacterial endotoxin, lipopolysaccharide, acts at all levels of the hypothalamic-pituitary-gonadal axis, resulting in long-lasting changes in reproductive function, suggesting that disposition to infertility may begin early in life.

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Neonatal immune challenge alters reproductive development in the female rat

Cited by 52 publications

References 86 publications

Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring

Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

Factors in Early-Life Programming of Reproductive Fitness

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