Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study

Bante, Agegnehu; Ahmed, Muluken; Degefa, Nega; Shibiru, Shitaye; Yihune, Manaye

doi:10.1016/j.heliyon.2024.e24838

Cited by 1 publication

(1 citation statement)

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“…For instance, a recent study reported that 24.46% of 417 newborn babies encountered neonatal jaundice in southern Ethiopia. 6 A similar incidence was previously reported in Nigeria with male neonates accounting for 56.8% of babies admitted with Jaundice whereas, 14% of the neonates developed complications as a result of jaundice that resulted in death (69.4%). 7 The global prevalence of severe neonatal jaundice ranged from 8.31% to 31.49% with the highest incidence recorded in Africa.…”

Section: Introductionsupporting

confidence: 73%

Ameliorative Effect of Faidherbia albida Against 2.4-Dinitrophenylhydrazine Induced Hyperbilirubinemia in Wistar Albino Rats

Tukur,

Abubakar,

Fakai

et al. 2024

JEP

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Background: Faidherbia albida, popularly known as gawo in Hausa, is traditionally used to treat jaundice in Zuru emirate of Kebbi State. Herein, the ameliorative effect of F. albida against 2.4-dinitrophenylhydrazine-induced hyperbilirubinemia in Wistar albino rats was investigated. Methods: Thirty healthy rats were administered 75 mg of 2.4-dinitrophenylhydrazine to induce hyperbilirubinemia. Thereafter, groups 1-3 received 500, 750, and 1000 mg/kg body weight of the methanol stem-bark extract, and 15 mg/kg of phenobarbitone (standard drug) was administered to group 4. Groups 5 and 6 served as the untreated and normal controls, respectively. The phytochemical composition was evaluated using standard methods, and acute oral toxicity was evaluated using standard OECD 2008 guidelines. Results: Phytochemical analysis revealed the presence of alkaloids, phenols, and a substantial amount of tannins. A significant (P<0.05) reduction of direct bilirubin, total bilirubin, and total protein levels for all the doses of the extract and standard drug compared to untreated groups was observed. Similarly, there were significant reductions in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels of the group treated with the standard drug and all extracttreated groups compared to elevated levels observed in untreated controls. However, a significant (P<0.05) increase in serum albumin (ALB) levels, red blood cells, hemoglobin, and pack cell volume was observed in all extract-treated compared to the untreated control in contrast to a significant decrease in MCH levels in treated groups compared to the untreated group. Conclusion: F. albida ameliorated the hyperbilirubinemia induced by 2.4-dinitrophenylhydrazine in Wistar albino rats, thus providing some support for its use in traditional medicine to treat jaundice.

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Section: Introductionsupporting

confidence: 73%