Neonatal jaundice and coagulopathy

Kurnetz, Ruben; Yang, S. Samuel; Holmes, Richard D.; Harrison, Duane D.

doi:10.1016/s0022-3476(85)80209-2

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…591 Premature infants are at particular risk for DIC. 592 As in adults, the most fre quent sites of hemorrhage are the skin, lung, and central nervous system, with the clinical course punctuated by hypoxia, acidosis, shock, and in fection. 592 Liver disease in association with clinical evi dence of DIC and hyperbilirubinemia suggests hepatic parenchymal dysfunction with intrahepatic cholestasis rather than extrahepatic cholestasis.…”

Section: Neonates and Infantsmentioning

confidence: 99%

“…592 As in adults, the most fre quent sites of hemorrhage are the skin, lung, and central nervous system, with the clinical course punctuated by hypoxia, acidosis, shock, and in fection. 592 Liver disease in association with clinical evi dence of DIC and hyperbilirubinemia suggests hepatic parenchymal dysfunction with intrahepatic cholestasis rather than extrahepatic cholestasis. 592 Infectious agents, including cytomegalovirus, her pesvirus, rubella, ECHO virus, coxsackievirus, ade novirus, hepatitis B virus, syphilis, and toxoplasma are to be strongly considered.…”

Section: Neonates and Infantsmentioning

confidence: 99%

“…592 Liver disease in association with clinical evi dence of DIC and hyperbilirubinemia suggests hepatic parenchymal dysfunction with intrahepatic cholestasis rather than extrahepatic cholestasis. 592 Infectious agents, including cytomegalovirus, her pesvirus, rubella, ECHO virus, coxsackievirus, ade novirus, hepatitis B virus, syphilis, and toxoplasma are to be strongly considered. 592 Hereditary galac tosemia, fructose intolerance, tyrosinemia, alphap antitrypsin deficiency, and cystic fibrosis are in herited metabolic disorders that should also be considered.…”

Section: Neonates and Infantsmentioning

confidence: 99%

“…592 Infectious agents, including cytomegalovirus, her pesvirus, rubella, ECHO virus, coxsackievirus, ade novirus, hepatitis B virus, syphilis, and toxoplasma are to be strongly considered. 592 Hereditary galac tosemia, fructose intolerance, tyrosinemia, alphap antitrypsin deficiency, and cystic fibrosis are in herited metabolic disorders that should also be considered. 592 As in adults, DIC may be associated with any cause of fulminant hepatic failure.…”

Section: Neonates and Infantsmentioning

confidence: 99%

“…592 Hereditary galac tosemia, fructose intolerance, tyrosinemia, alphap antitrypsin deficiency, and cystic fibrosis are in herited metabolic disorders that should also be considered. 592 As in adults, DIC may be associated with any cause of fulminant hepatic failure. In approaching the neonate with bleeding, it is useful to distinguish those who are clinically ill from those who are clinically well.…”

Section: Neonates and Infantsmentioning

confidence: 99%

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Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

Baker¹

1989

Semin Thromb Hemost

151

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DIC is a disorder of coagulation that is demonstrated to occur in many settings. In view of the fulminant nature of the disorder once it is fully activated, the potential for considerable morbidity and mortality, and the difficulty in treating this syndrome, the necessity for a thorough understanding of the disorder is clear. A high index of suspicion is absolutely essential; however, this requires a thorough knowledge of the medical and surgical disorders in which DIC is likely to occur. The presenting manifestations of DIC, the time course of development of the fulminant syndrome, and the specific complications of the disorder may be intrinsically related to the specific clinical characteristics of the underlying disease. Clinical evaluation of the patient must be comprehensive and consider not only the laboratory and clinical manifestations of DIC but the triggering illness. Without the ability to treat the underlying primary illness, controlling or abating the DIC may be difficult or impossible. This comprehensive review of the disease entities in which DIC is likely to occur and the associated clinical manifestations will, it is hoped, guide a more precise definition of the overall clinical picture that confronts the clinician when evaluating a patient with possible DIC.

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Section: Neonates and Infantsmentioning

confidence: 99%