Neonatal jaundice and glucose-6-phosphate dehydrogenase deficiency in Basrah

Al-Naama, Lamia M.; Al-Sadoon, Imad A.; Al-Naama, Menhel M.

doi:10.1080/02724936.1987.11748490

Cited by 23 publications

(9 citation statements)

References 14 publications

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“…After incubation, antimicrobial activity was evaluated by measuring the zone of inhibition against tested microorganisms. Antimicrobial activity was expressed as inhibition diameter zones in millimeters (mm) . Inhibition zones (I.Z.)…”

Section: Resultsmentioning

confidence: 99%

Exploration of quinoxaline derivatives as antimicrobial and anticancer agents

Bayoumi

Ghiaty

El‐Gilil

et al. 2019

Journal of Heterocyclic Chem

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Novel 2 and 3‐substituted quinoxaline derivatives were synthesized through various synthetic pathways, among which cyanoacetamide and cyanoacetohydrazide quinoxaline derivatives 4a‐c and 11a‐c, respectively, were synthesized. Furthermore, methoxy quinoxaline derivatives 3c and quinoxaline derivatives bearing substituted pyridines 6a,b, 12a,b, and 13a,b were designed to be synthesized. However, we have synthesized acrylohydrazide 5a,b and 7/acrylamide derivatives, Schiff base analogues 14a‐f, pyrazole derivatives 15a‐e, amide derivatives 16a‐f, guanidine derivatives 16 g,h as well as, quinoxalin‐2‐methylallyl propionate derivative 14g. All the synthesized compounds were confirmed via spectral data and elemental analyses. Moreover, the newly synthesized compounds were evaluated for their antimicrobial activity (Gm +ve, Gm −ve in comparison to Gentamycin a standard) and fungi (in comparison to Ketoconazole as a standard). Thus, compound 16b showed promising antimicrobial activity against B. subtilis, P. vulgaris, and S. mutants with values ranging from 20 to 27‐mm zone of inhibition. While compounds 5a, 14e,f, and 16a,c,d,g,h showed potent antimicrobial activity. Moreover, the National Cancer Institute (NCI) selected 20 compounds that were submitted for anticancer screening against 60 types of cancer cell lines. The most active compounds are 5b and 12a where compound 5b containing 2,4‐dichlorophenyl moiety at cyanoacetamide linkage of hydrazine quinoxaline backbone exerted significant growth inhibition activity against Leukemia MOLT‐4, Renal cancer UO‐31, and Breast cancer MCF‐7. In addition, compound 12a having 4,6‐diaminopyridinone side chain at position‐3 of quinoxaline nucleus exhibited remarkable anticancer activity against renal cancer UO‐31.

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Section: Resultsmentioning

confidence: 99%

Exploration of quinoxaline derivatives as antimicrobial and anticancer agents

Bayoumi

Ghiaty

El‐Gilil

et al. 2019

Journal of Heterocyclic Chem

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“…22 On the other hand, there are controversial results as the association between ABO incompatibility and G6PDH enzyme deficiency increases the severity of hemolysis and UCH. [23][24][25][26] Therefore, the levels of G6PD, PK enzymes, reducing substances in urine, thyroid function tests, and sepsis screening were studied due to the detection of severe hemolysis and UCH that could not be controlled by phototherapy and IVIG in our case with ABO incompatibility-related hemolysis and UCH.…”

Section: Discussionmentioning

confidence: 99%

Hemolysis due to Alpha-Hemolytic Enterococcus Urinary Infection: A Rare Cause of Early and Severe Unconjugated Hyperbilirubinemia in a Neonate

Karabulut

Gafil

2020

J Pediatr Intensive Care

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The reason for reporting this case is to remind that some microorganisms may cause hemolysis leading to early and severe hyperbilirubinemia by secreting hemolysin in cases; where bilirubin levels cannot be successfully decreased despite effective phototherapy, intravenous immunoglobulin, and even exchange transfusion, or in cases of increased rebound bilirubin (although urinary tract infection is associated with increased conjugated bilirubin fraction and prolonged jaundice). The most common causes of hemolysis are ABO/Rh incompatibility and enzyme deficiencies such as glucose-6-phosphate dehydrogenase (G6PDH), pyruvate kinase (PK), and galactose-1-phosphate uridyltransferase (GALT). Our patient was a male infant, weighing 3,160 g, at 38 + 4 gestational week; he was referred to our unit with total bilirubin level of 14.7 mg/dL recorded at the postnatal 20th hour and was initiated treatment with intensive phototherapy and prepared for exchange transfusion. The G6PD, PK, and GALT enzyme levels studied at the postnatal 96th hour and reducing substances in urine were detected to be normal/negative, whereas complete urinalysis revealed pyuria (7 leukocytes per each high power field). α-hemolysis-producing 105 colony-forming unit/mL Enterobacter cloacae grew on blood agar in the urine culture. As reported in our case, hemolysin-secreting α and β-hemolytic bacteria can lead to severe and early hemolysis and unconjugated hyperbilirubinemia, as in blood type incompatibility and enzyme deficiencies.

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“…Sarılıklı G6PD enzim eksikliği olan grupta sarılığın başladığı gündeki total bilirubin değeri, maksimum total bilirubin değeri ve patolojik ikter belirgin yük-sek bulundu (p=0,04, p=0,002, P=0,001) (Tablo 2). Tartışma G6PD enzim eksikliği yenidoğanlarda hiperbilirubinemi ve kernikterus riskini arttırdığından G6PD enziminin yenidoğan döne-minde taranması önem kazanmıştır [14]. G6PD enzim eksikliği tarama programlarının çoğu kordon kanında yapılmıştır.…”

Section: Bulgularunclassified

“…Al-Naama ve ark. [14] 186 hiperbilirubinemili yenidoğanın 95'inde (%51) G6PD enzim eksikliği saptamıştır. Serum bilirubin seviyesi olguların %46'sında 20 mg/dl üzerinde %30'unda 15-20 mg/dl arasında, %24'ünde 15 mg/dl altında bulunmuştur.…”

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Screening of Glucose-6-Phosphate Dehydrogenase Deficiency in Cord Blood

2014

Ann Clin Anal Med

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ÖzetAmaç: Yenidoğan sarılığının patolojik nedenleri içerisinde glukoz-6-fosfat dehidrogenaz enzim eksikliği önemli yer tutar. Bu çalışma Trakya Üniversitesi Tıp Fakültesi Hastanesi'nde doğan yenidoğanların kordon kanında glukoz-6-fosfat dehidrogenaz enzim eksikliği taraması ve neonatal hiperbilirubinemideki önemini göstermek amacıyla yapılmıştır. Gereç ve Yöntem: Bu çalışma-ya 556'sı (%54.8) erkek, 459'u (%45.2) kız 1015 yenidoğan alındı. Olguların cinsiyet, doğum tartısı, boy, baş çevresi ve gestasyon yaşı kaydedildi. Yenidoğanların kordon kanında kantitatif yöntemle glukoz-6-fosfat dehidrogenaz enzim düzeyi ölçüldü ve hemoglobin, hematokrit, eritrosit sayısı ve kan grubu çalışıldı. Sarılık gelişen olgularda, sarılığın başlama zamanı, sarılığın baş-ladığı gündeki total bilirubin düzeyi, maksimum bilirubin düzeyi, pik bilirubin günü, fizyolojik ve patolojik sarılık, fototerapi tedavisi ve kan değişimi kaydedildi. Bulgular: Enzim eksikliği saptanan 133 (%13,1) olgunun 76'sı (%57) erkek, 57'si (%43) kız idi. Sarlıklı glukoz-6-fosfat dehidrogenaz enzim düzeyi dü-şük grupta, sarılığın başladığı gündeki total bilirubin değeri, maksimum total bilirubin değeri ve patolojik ikter belirgin yüksek saptandı (p<0.05). Tartışma:Bu çalışmada glukoz-6-fosfat dehidrogenaz enzim eksikliği oranı %13.1 olarak saptandı ve bu oran ülkemizde yapılan diğer çalışmalardan daha yüksek-tir. Bu nedenle bölgemizdeki yenidoğanların kordon kanında enzim tayini yapılmalı ve riskli yenidoğanlar hiperbilirubinemi gelişmesi açısından yakından takip edilmeli ve bu konuda aileler bilgilendirilmelidir. Anahtar KelimelerGlukoz-6-Fosfat Dehidrogenaz; Yenidoğan; Sarılık Abstract Aim: Glucose-6-phosphate dehydrogenase deficiency is an important factor in etiology of pathologic neonatal jaundice. The aim of this study was to indicate the significance of screening glucose-6-phosphate dehydrogenase deficiency in the cord blood of neonates and the frequency of this deficiency in the etiology of neonatal hyperbilirubinemia. Material and Method: The study was performed consecutive 1015 neonates were included. Five hundred fifty six (54.8%) of them were male and 459 (45.2%) were female. The following parameters were recorded: Gender, birth weight, birth height, head circumference and gestational age. The glucose-6-phosphate dehydrogenase level of neonates were measured with quantitative method in cord blood. Also, hemoglobine, hematocrite, red blood cell count and blood group were measured. The following parameters were recorded in cases with jaundice: exchange transfusion, phototherapy, physiologic and pathologic jaundice, peak bilirubin day, maximum bilirubin level, total bilirubin level at the first day of jaundice, beginning time of jaundice. Results: Enzyme deficiency was detected in 133 (13.1%) of neonates and 76 (57%) of them were male, 57 (43%) were female. Significant difference was detected in low glucose-6-phosphate dehydrogenase enzyme level with jaundice group for total bilirubin level at the first day of jaundice, maximum total bilirubin level an...

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Neonatal jaundice and glucose-6-phosphate dehydrogenase deficiency in Basrah

Cited by 23 publications

References 14 publications

Exploration of quinoxaline derivatives as antimicrobial and anticancer agents

Exploration of quinoxaline derivatives as antimicrobial and anticancer agents

Hemolysis due to Alpha-Hemolytic Enterococcus Urinary Infection: A Rare Cause of Early and Severe Unconjugated Hyperbilirubinemia in a Neonate

Screening of Glucose-6-Phosphate Dehydrogenase Deficiency in Cord Blood

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