Neonatal jaundice is a risk factor for childhood asthma: a retrospective cohort study

Ku, Min‐Sho; Sun, Hai-Lun; Sheu, Ji-Nan; Lee, Hong-Shen; Yang, Shun‐Fa; Lue, Ko-Huang

doi:10.1111/j.1399-3038.2012.01345.x

Cited by 37 publications

(48 citation statements)

References 20 publications

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“…The authors hypothesized that this could have been due to a drug effect, but whether the risk was due to more severe maternal disease was unable to be determined. It is important to note that prior studies have identified neonatal jaundice 16 or treatment for jaundice 17 as a predictor of childhood asthma, but these reports have not taken maternal asthma into account. Perhaps maternal asthma, which increases risk for asthma among offspring, 18 is a common cause for both neonatal jaundice and childhood asthma.…”

Section: Discussionmentioning

confidence: 99%

Neonatal health of infants born to mothers with asthma

Mendola

Männistö

Leishear

et al. 2014

Journal of Allergy and Clinical Immunology

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Background Maternal asthma is associated with serious pregnancy complications but newborn morbidity is understudied. Objective To determine if infants of asthmatic mothers have more neonatal complications. Methods The Consortium on Safe Labor (2002–2008), a retrospective cohort, included 223,512 singleton deliveries at ≥ 23 weeks’ gestation. Newborns of mothers with asthma (n=17,044) were compared to newborns of non-asthmatic women using logistic regression models with generalized estimating equations to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI). Electronic medical record data included gestational week at delivery, birthweight, resuscitation, neonatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia, respiratory distress syndrome, apnea, sepsis, anemia, transient tachypnea of the newborn, infective pneumonia, asphyxia, intracerebral hemorrhage, seizure, cardiomyopathy, peri- or intraventricular hemorrhage, necrotizing enterocolitis, aspiration, retinopathy of prematurity and perinatal mortality. Results Preterm delivery was associated with maternal asthma for each week after 33 completed weeks of gestation and not earlier. Maternal asthma also increased the adjusted odds of small for gestational age (SGA, OR=1.10, CI:1.05–1.16), NICU admission (OR=1.12, CI:1.07–1.17), hyperbilirubinemia (OR=1.09, CI:1.04–1.14), respiratory distress syndrome (OR=1.09, CI:1.01–1.19), transient tachypnea of the newborn (OR=1.10, CI:1.02–1.19), and asphyxia (OR=1.34, CI:1.03–1.75). Findings persisted for term infants (≥ 37 weeks) who had additional increased odds of intracerebral hemorrhage (OR=1.84, CI: 1.11–3.03) and anemia (OR=1.30, CI: 1.04–1.62). Conclusions Maternal asthma was associated with prematurity and SGA. Adverse neonatal outcomes including respiratory complications, hyperbilirubinemia, and NICU admission were increased in association with maternal asthma even among term deliveries.

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Section: Discussionmentioning

confidence: 99%

Neonatal health of infants born to mothers with asthma

Mendola

Männistö

Leishear

et al. 2014

Journal of Allergy and Clinical Immunology

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“…Four previous studies have reported the association between neonatal jaundice and asthma (11)(12)(13)(14). Two studies in Sweden conducted by Aspberg et al first reported the association of neonatal jaundice and phototherapy with childhood asthma requiring hospitalization (odds ratio = 1.27, 95% CI = 1.08, 1.50) and confirmed that neonatal jaundice and phototherapy are associated with the use of antiasthmatic drugs before 12 y of age (odds ratio = 1.30, 95% CI = 1.16, 1.47) in their subsequent analysis (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…A reduction in the level of IL-2 skews the Th1/ Th2 balance toward Th2, thereby increasing the risk of atopy development (9,10). Although previous studies have reported the relationship of neonatal jaundice with childhood asthma, few studies have systemically analyzed the association between neonatal jaundice and common childhood allergic diseases (11)(12)(13)(14)(15). The prevalence of allergic diseases has risen dramatically worldwide, creating a health care burden.…”

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confidence: 99%

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

et al. 2015

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Background:Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. Methods: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated. results: The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion. conclusion: Neonatal jaundice is associated with the development of allergic diseases in early childhood.

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“…Several Taiwan studies had demonstrated the high accuracy and validity of ICD-9 diagnosis in NHIRD. Taiwan launched a national health insurance (NHI) in 1995, operated by a single-buyer, the government [7,[12][13][14]. Medical reimbursement specialists and peer review should scrutinize all insurance claims.…”

Section: Study Populationmentioning

confidence: 99%

“…Increasingly more studies have focused on early-life events, such as respiratory viral infections, that may increase the risk of childhood asthma [3][4][5]. Other perinatal risk factors-including babies born preterm, of low birth weight, with respiratory distress syndrome or neonatal jaundice, and needing positive pressure ventilation at birth-increase susceptibility to asthma [2,6,7]. Numerous studies have suggested that early exposure to infections in utero or early in life is a potentially critical risk factor in the development of allergic disease [6,[8][9][10].…”

Section: Introductionmentioning

confidence: 98%

Neonatal urinary tract infection may increase the risk of childhood asthma

Lin

Wang

Lin

et al. 2015

Eur J Clin Microbiol Infect Dis

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The aim of this population-based retrospective cohort study was to investigate the onset of urinary tract infection in newborns and the associated risks of childhood asthma. Children with neonatal UTI (n = 3,312) and randomly selected controls (n = 13,243) were enrolled for our analysis. We calculated the follow-up person-years for each participant from the index date until the diagnosis of asthma, the end of 2008, or withdrawal from the insurance system (because of death or loss to follow-up). Furthermore, we compared the risk of asthma between non-UTI and UTI cohorts by using Cox proportional hazards model analysis, the adjusted hazard ratio (aHR), and a 95 % confidence interval (95 % CI). The overall asthma incidence rate was found to be 1.53-fold significantly higher in the UTI cohort than in the non-UTI cohort (70.3 vs 45.8 per 1000 person-years). After we adjusted for potential risk factors, the overall risk of asthma remained higher in the UTI cohort (aHR = 1.47, 95 % CI = 1.35-1.59). The incidence rate was higher in boys than in girls. Overall, patients suffering from UTI may have a greater risk of developing asthma than patients without UTI. This nationwide retrospective cohort study demonstrates that neonatal UTI may increase the risk of childhood asthma.

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Neonatal jaundice is a risk factor for childhood asthma: a retrospective cohort study

Abstract: Neonatal jaundice increased the rate and severity of childhood asthma in subjects aged up to 10 yr and may be a risk factor for childhood asthma.

Cited by 37 publications

References 20 publications

Neonatal health of infants born to mothers with asthma

Neonatal health of infants born to mothers with asthma

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

Neonatal urinary tract infection may increase the risk of childhood asthma

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