Neonatal lateralization of behavior and brain dopaminergic asymmetry

Afonso, D.; Santana, C.; Rodrı́guez, Manuel

doi:10.1016/0361-9230(93)90312-y

Cited by 48 publications

(16 citation statements)

References 32 publications

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“…Meanwhile, the movements of unpaired appendages, such as the tail, can also be lateralized as shown for primates (Laska and Tutsch, 2000;Hanbury et al, 2010), rats (Denenberg and Yutzey, 1985;Afonso et al, 1993), and dogs (Quaranta et al, 2007). A distinctive example of this type of lateralization is asymmetrical trunk use in elephants.…”

Section: Animal Behaviourmentioning

confidence: 99%

Context-dependent lateralization of trunk movements in wild Asian elephants

Giljov

Silva

Karenina

2017

BioComm

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Asymmetrical trunk use in elephants represents a distinctive example of motor lateralization. Previous studies have shown that trunk movements in the elephant behaviour associated with feeding is lateralized at the individual, but not the population level. The manifestation of lateralized behaviour depends on the nature of the behaviour and is usually more pronounced in social context. Therefore, we hypothesized that population-level lateralization of trunk use in elephants is manifested in social behaviour. One-sided biases in trunk movements were assessed in wild individually-identified Asian elephants during feeding (tearing off a tuft of grass) and social interactions (trunk-to-mouth contacts and trunk-to-genitals contacts between male initiator and female recipient). In feeding, lateralization at the individual and population levels was estimated based on 50 lateral trunk uses per individual. In social interactions, only the population-level bias was assessed using a single trunk contact from each individual. For trunk movements during feeding, elephants showed robust individual preferences, but no population-level lateralization. The distribution of right-and left-trunkers in the present study did not differ significantly from that obtained in previous studies of both the same elephant population and geographically distinct population. No population-level bias in trunk movements during trunk-to-mouth contacts was revealed. In trunk-to-genitals contacts, in contrast, a population-level lateralization was found. Right-sided trunk movements prevailed in males touching females. While individual preferences for feeding, combined with the absence of one-sided population bias, is obviously a species-typical characteristic of Asian elephants, social behaviour, such as male-female socio-sexual contacts, can elicit population-level lateralization of trunk use in this species. The right-sided bias in trunk-to-genitals contacts may reflect lateralization of olfactory perception. If this is the case, the revealed lateralization indicates a right-hemispheric advantage in the processing of social information which is consistent with the general tendency in mammals.

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Section: Animal Behaviourmentioning

confidence: 99%

Context-dependent lateralization of trunk movements in wild Asian elephants

Giljov

Silva

Karenina

2017

BioComm

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“…Afonso et al (1993) postulated that the behavioral and biochemical asymmetries in animals are conditioned by phenomena present during prenatal or very early neonatal life. Dimorphic behavioral changes and brain asymmetries were observed in neonatal rats after prenatal alcohol exposure (Zimmerberg and Reuter, 1989) when reduced volumes of the hippocampus and neocortex (considered as 'feminized asymmetry' in males) and changes in postural position were documented at birth.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin

et al. 2005

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Sex-specific patterns of cerebral cortical lateralization have been documented consistently in both the human and animal brain. Male rats tend to exhibit pronounced right hemisphere dominance compared with females, while females typically exhibit more diffuse lateralization patterns and greater left hemisphere bias compared with males. Prenatal TCDD (2,3,7,8 tetrachlorodibenzo-p-dioxin) exposure produces demasculinization of male offspring sexual behavior, suggesting interference with sexual differentiation of the brain. In previous studies, a reversal of cortical thickness patterns in rats was shown after prenatal TCDD exposure on gestational day 8 (GD 8). The current study, based on the same brain sections, attempted to define changes in the number of cortical cells and cell size distributions in brains of offspring from TCDD-treated dams. Pregnant females were given a single oral dose of 0 or 180 ng kg(-1) TCDD on GD 8. Cell counts and sizes were determined in 3-month-old offspring. Areas 17 and 18a at bregma -3.8 were analysed using digitized, enhanced images of brain sections produced by a photomicroscope fitted with a high-resolution digital camera. Prenatal TCDD exposure altered the relative proportions of smaller and larger cell sizes in male, but not in female offspring. Both exposed males and females, however, exhibited a significant reversal of hemispheric dominance based on cell number. These findings demonstrate that prenatal exposure to TCDD alters the normal patterns of cortical cell asymmetry in a manner consistent with our previous data on thickness patterns.

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“…Postural and behavioral asymmetries have been documented extensively in mice and rats (10,16,30,37), even in their first days of life (1,10). In experimental conditions mice show a pro nounced, enduring, and not task specific preference for the use of either the right or the left forepaw (7,31).…”

Section: Discussionmentioning

confidence: 99%

“…Most murine strains have a right paw preference, but some preferentially use the left paw (21). Interestingly, the degree of lateralization increases under stress conditions and after practice (2,28), especially prac tice in the postnatal phase (l), and once obtained lateralization remains present throughout the animal's life span (1). As to CB1 myositis, in neonatally inoculated mice acute and chronic disease means a stressful condition and bilateral muscle weakness forces the animal to practice in the postnatal days; hence, hind leg lateralization may increase considerably and become manifest.…”

Section: Discussionmentioning

confidence: 99%

“…C uri ously, the right leg seem ed m ore affected than the left one, both on observation and on qualitative m icroscopy (26,27,32,35). At present, however, no quantified observational data have been reported on predominant right leg dysfunction in C B 1 (24,26,27,32,35,36); no plausible explanation has been put forward for the right leg bias. To answer these ques tions, we quantified m otor asym m etries in mice with CB1 myosi tis on repeated observation and studied mononuclear cell infiltra tion and muscle fiber necrosis in right-and left-sided hamstring muscles on quantitative microscopy.…”

mentioning

confidence: 91%

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Predominant right leg dysfunction without asymmetric muscle inflammation in CD1 Swiss mice with coxsackievirus B1-induced myositis

Jongen

Eling

Putte

1996

Physiology & Behavior

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INC) AND L. B. A. VAN DH PUTTL. Predom inant right teg dysfunction w ithout asym m etric m uscle inflammation in C D ! Swiss m ire with Coxsackievirus B l-in d u c e d m yositis. P H Y S IO L B E H A V 5 9 (4 /5 ) 763-76N, 1996.■•-■To establish the existence of predominant right leg involvement in Coxsackievirus B l-induced myositis (CBI myositis) 1S9 neonatal CD! Swiss mice were inoculated with 300 pfu C B I, and regularly observed for posture, mobility, and gait. After 2 and 4 weeks, quantitative comparison of m otor dysfunction o f right and left leg yielded an asymmetry score; on light microscopy mononuclear cell infiltration and m uscle fiber necrosis were quantified in bilateral hamstring muscles, using a five-grade scale (0 -4 ). M otor asym m etries were seen during acute viral myositis as soon as hind leg dysfunction appeared, and animals with a predom inant dysfunction of one leg preserved that preference throughout the observation period. At 2 weeks, mice with predom inant right leg dysfunction i n 1 -34) significantly outnumbered those with predominant left leg dysfunction ( n = 11) ( p = 0.01). At 2 and 4 weeks, infiltration ami necrosis in hamstrings from legs with predominant dysfunction were not higher than in those from contralateral legs, and infiltration in right-sided hamstrings was not higher than in left-sided ones, nor was infiltration at 4 weeks. At 4 weeks right-sided muscles were more necrotic (mean ± SD, L 8 ± 1.5) than left-sided muscles (L I j 1.2; /> ^ 0,03). In the absence of predominant inflammatory disease of the right leg, we interpret the hind leg asymmetry as a preferential use of the left leg, due to left-leggedness, and suggest that in CD1 Swiss mice eft-leggednes is associated with increased susceptibility to CB1 myositis. Coxsackievirus BMyositis Murine Asymmetry Lateralization Pathology

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Neonatal lateralization of behavior and brain dopaminergic asymmetry

Cited by 48 publications

References 32 publications

Context-dependent lateralization of trunk movements in wild Asian elephants

Context-dependent lateralization of trunk movements in wild Asian elephants

Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin

Predominant right leg dysfunction without asymmetric muscle inflammation in CD1 Swiss mice with coxsackievirus B1-induced myositis

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