Neonatal limited bedding and nesting experience may lead to a sex‐dependent increase in panic‐like defensive behaviours in adult mice
Heloisa Helena Vilela‐Costa,
Paloma Molina Hernandes,
Jefferson Manoel Nascimento‐Silva
et al.
Abstract:In humans, adverse physical and/or psychological traumas in childhood may predispose to developing psychiatric disorders in adulthood, including panic disorder. To model early life adversity in mice, we subjected male and female C57BL/6 J mice to a limited bedding and nesting (LBN) protocol between postnatal days 2–9 and investigated its effect on responsiveness to panicogenic challenges in adulthood. Panic‐like escape behaviour was assessed during exposure to a high concentration of CO2 (20%) or in the beetle… Show more
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