Neonatal Lupus Erythematosus

Nasef, Nehad; Hafez, Mona; Bakr, Ashraf

doi:10.24966/ncp-878x/100002

Cited by 10 publications

(16 citation statements)

References 103 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Prenatal screening of anti-SSA/Ro and anti-SSB/La antibodies is needed before conception or as soon as possible, especially in patients with known Sjögren's syndrome. 11 The main symptom of this disease is Sicca syndrome. 17 A person suffering from Sjögren's syndrome will feel dryness on mouth and eye.…”

Section: Discussionmentioning

confidence: 99%

“…16 There is no guideline on the frequency of examinations, some carry out Doppler examinations for 18-26 weeks and every 2 weeks after 32 weeks of age. 11 The therapy is expected to reduce maternal autoantibodies, thereby reducing placental transfer and reducing inflammation before permanent fibrosis and irreversible CHB occur. Early diagnosis and therapy are expected to improve prognosis, especially in cases of incomplete CHB.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive management of pregnant woman with Sjögren’s syndrome

Gunawan

Rahadina

Prasetyo

2022

MOG

View full text Add to dashboard Cite

HIGHLIGHTS 1. Sjögren’s syndrome is a chronic autoimmune disease that attacks the exocrine glands, especially lacrimal and salivary glands. 2. Comprehensive management of pregnant women with Sjögren’s syndrome was described.3. Clinical and laboratory examination, risk assessment and also preconception counseling before planning pregnancy are needed by women with Sjögren’s syndrome. ABSTRACT Objective: To illustrate the comprehensive management of pregnant women with Sjögren syndrome. Case Report: A 24 years old women came to Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, due to Sjögren syndrome in 35/36 weeks of gestasional age for routine examination. She was first diagnosed with Sjögren syndrome in February 2018 because she complained of dry eyes and hair fall out. This was her first pregnancy. Laboratory result showed positive ANA test. The patient had hypertension with controlled blood preasure and dry eyes. The patient was diagnosed with primigravida 35-36 weeks of pregnancy, single live intrauterine, head presentation, IUGR, screening preeclampsia was positive, and there was complication with Sjögren’s syndrome. The patient was treated by multidisciplinary team consisting of obstetricians, internists, ophthalmologists and neonatologists. Conclusion: Sjögren’s syndrome is a chronic autoimmune disease that attacks the exocrine glands, especially lacrimal and salivary glands. The exact cause of Sjögren's syndrome is still not known. Women with Sjögren’s syndrome should have clinical and laboratory examination, risk assessment and also preconception counseling before planning pregnancy because Sjögren syndrome was a rare case during pregnancy. Close monitoring and proper management was imperative to detect the early complication.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comprehensive management of pregnant woman with Sjögren’s syndrome

Gunawan

Rahadina

Prasetyo

2022

MOG

View full text Add to dashboard Cite

show abstract

“…It appears during the first 3 months after birth, lasts for a mean of 4 months, and disappears spontaneously by 6-8 months of age as the maternal Ab in baby's circulation disappear. However 10%-25% of patients manifest residual skin abnormlities such as telangiectasias, dyspigmentation, pitting, scarring, and skin atrophy [5].…”

Section: Discussionmentioning

confidence: 99%

“…If the mother is anti-SSA/Ro Ab positive, it is found in 2% of fetuses. In case of anti-SSA/Ro Ab and anti-SSB/La Ab positive, it is found in 5% of fetuses [5,8]. While the non-cardiac symptoms are usually reversible, the congenital heart block is permanent and approximately 20% may be accompanied by cardiomyopathy and death from heart failure [2].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Neonatal Lupus and Literature Review

Kim

Lee

Kim

et al. 2018

Soonchunhyang Med Sci

View full text Add to dashboard Cite

Neonatal lupus is a rare rheumatic disease. Clinical manifestations include characteristic annular or macular rashes, congenital heart block, cytopenias, and hepatitis. Neonatal lupus is caused by transmission of maternal immunoglobulin G autoantibodies such as anti-SSA/Ro antibody or anti-SSB/La antibody to the fetus through the placenta. We report two cases of neonatal lupus. The first case refers to an 18-day-old male with annular rashes on both cheeks, neutropenia, positive tests for antinuclear antibody, anti-SSA/ Ro antibody, and anti-SSB/La antibody. His mother was diagnosed with systemic lupus erythematosus characterized by positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. The second case represents a 32-day-old female with annular rash on both hands, soles, and the genital area, neutropenia, hepatitis, positive tests for antinuclear antibody, and anti-SSA/Ro antibody. Skin punch biopsy was conducted. Her mother did not have history of connective tissue diseases. We referred her mother to the division of rheumatology of the department of internal medicine. The mother was suspected with primary Sjögren's syndrome because of arthralgia and dry eye symptoms with positive tests for antinuclear antibody, anti-SSA/Ro antibody, anti-SSB/ La antibody, and rheumatoid factor. It is necessary to suspect neonatal lupus in neonates or infants with characteristic annular rash with or without maternal history of connective tissue disorders.

show abstract

“…It occurs in infants born to mothers with rheumatic conditions including, but not restricted to, systemic lupus erythematosus. Most clinical manifestations of NLE resolve spontaneously with vanishing of maternal auto-antibodies from the neonatal circulation except congenital complete heart block [8]. However, only 1% of infants with positive maternal autoantibodies develop neonatal lupus erythematosus and some cases are born to asymptomatic mothers who are unaware of their autoimmune disorders and get their seropositivity discovered after an affected infant.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Positive Anti-Ro/SSA and Anti-La/SSB Antibodies Among Infants with Prolonged Skin Lesions and Its Relation to Autoimmune Disease in the Mother

Makhlouf¹

2018

IJI

View full text Add to dashboard Cite

Many literatures reported that neonatal lupus erythematosus and its associated abnormalities mainly, cutaneous lupus lesions, congenital heart block (CHB), hematologic cytopenias, hepatobiliary disease and cardiomyopathy are associated with anti-Ro/SSA and anti-La/SSB antibodies. With skin findings occur in nearly 95% of NLE infants, others reported that 100% of NLE infants with CHB were positive for anti Ro/SSA antibodies and 90.2% of infants with skin NLE were positive for anti Ro/SSA. And long-term follow-up of children with neonatal lupus and their unaffected siblings revealed that 12.24% of NLE children identified definite rheumatic/autoimmune diseases after more than 8 years. Aim of the study: The aim of this study was to determine the incidence of positive anti-Ro/SSA and anti-La/SSB antibodies in infants with recurrent prolonged skin lesions and their mothers to determine asymptomatic mothers at risk to develop autoimmune disease. Subjects and methods: a total of 90 infants with recurrent prolonged skin lesions below the age of 6 months and their mothers attending pediatric screening and follow up clinic at Al Galaa Teaching Hospital in Cairo, Egypt were investigated for positivity of anti Ro/SSA and anti La/SSB antibodies using enzyme linked immunoassay (ELISA). Results: Incidence rate of positive anti Ro/SSA alone and anti La/SSB alone antibodies in infants were 34.4% and 23.3% respectively, and positive both anti Ro/SSA and anti La/SSB antibodies was 21.1%, while in their mothers, positive both anti Ro/SSA and anti La/SSB antibodies was 36.7%. Among the 33 cases with positive antibodies female: male ratio was 2.3:1, and rheumatologic and autoimmune diseases was positive in 14 (42.4%) mothers, while, 19 (57.6%) were asymptomatic mothers, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia and thrombocytopenia were found in 6.1%, 9.1%, 3.0%, 9.1% and 12.1% respectively. Liver transaminases were elevated in 4 (12.1%). Positive anti Ro/SSA and anti La/SSB antibodies were statistically significantly correlated with infant age, body weight, body length and head circumference, female sex, infants mothers' rheumatologic and autoimmune diseases, distribution of skin lesions, positive history of steroid containing cream use, and thrombocytopenia. However, both antibodies showed no statistically significant correlation with infant feeding, rate of recurrent skin lesions, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia, positive CRP, and elevated ESR. Conclusion: our infant cases with prolonged skin lesions with positive anti Ro/SSA and anti La/SSB antibodies with their mothers' especially asymptomatic ones should be investigated and followed up properly for development of NLE and autoimmune diseases.

show abstract

Neonatal Lupus Erythematosus

Cited by 10 publications

References 103 publications

Comprehensive management of pregnant woman with Sjögren’s syndrome

Comprehensive management of pregnant woman with Sjögren’s syndrome

Two Cases of Neonatal Lupus and Literature Review

Incidence of Positive Anti-Ro/SSA and Anti-La/SSB Antibodies Among Infants with Prolonged Skin Lesions and Its Relation to Autoimmune Disease in the Mother

Contact Info

Product

Resources

About