Neonatal lupus erythematosus or Sweet syndrome?

Spengane, Zandile; Hlela, Carol; Pillay, Komala

doi:10.1016/j.jdcr.2018.06.002

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Neutrophil‐rich infiltrates have been reported in seven cases of NLE, as summarized in Table 1 1,6–10 . However, several cases of infants with figurate erythema and neutrophilic histopathologic infiltrates have also been reported in the literature, which have been classified as Sweet syndrome or neutrophilic figurate erythema.…”

Section: Discussionmentioning

confidence: 99%

“…Histiocytoid neutrophilic dermatitis has typically been described in association with Sweet syndrome. However, pathology resembling histiocytoid Sweet syndrome has also been described as a rare histopathologic variant of pediatric and neonatal lupus 1,6–10 . In other neutrophilic dermatoses, such as Sweet syndrome, histiocytoid variants are sometimes associated with myelodysplastic syndromes, hematological malignancies and malignant neoplasms 11,12 .…”

Section: Discussionmentioning

confidence: 99%

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Neonatal lupus erythematosus presenting as a non‐bullous histiocytoid neutrophilic dermatosis

et al. 2023

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Histopathologic findings in neonatal lupus erythematosus (NLE) are usually congruent with those of subacute cutaneous lupus erythematosus. However, neutrophilic dermatosis-type histopathologic features are being increasingly recognized in the literature including rare cases with variant histiocytoid morphology. We report the case of a 7-week-old male presenting with figurate erythema. His mother was found to have elevated anti-nuclear antibodies and was positive for anti-SSA/Ro, anti-SSB/La antibodies and Ro52 autoantibodies. The infant had a similar serological profile. Skin biopsy showed a histiocytoid interstitial infiltrate with mild lichenoid features, sparse neutrophils and mild leukocytoclasis. The histiocytoid infiltrate showed prominent CD68, CD163, and myeloperoxidase expression.Isolated clusters of CD123 + histiocytes were also present. This case highlights the rare finding of non-bullous neutrophilic dermatosis with histiocytoid change in neonatal lupus. In neonates presenting with figurate erythemas with morphological histiocytic change on biopsy, NLE should be considered as a differential diagnosis and investigated for accordingly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neonatal lupus erythematosus presenting as a non‐bullous histiocytoid neutrophilic dermatosis

et al. 2023

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“…Sweet's syndrome can be classified as primary or secondary. Secondary Sweet's syndrome can be associated with inflammatory conditions including infections and autoimmune diseases, paraneoplastic or drug related [4].…”

Section: Discussionmentioning

confidence: 99%

A case of infantile Sweet’s syndrome

Selvakumari¹,

Raghavendra²,

Patra³

2020

Our Dermatol Online

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Sweet's syndrome is a dermal neutrophilic inflammatory dermatosis characterized by unrestricted neutrophil production with consequent infiltration of the skin and in some cases other organs. We report a 4 month old baby boy with multiple well-defined skin coloured to erythematous, edematous papules and plaques studded with sterile pustules along the periphery involving the entire body since 1 week with sparing of palms, soles and mucosae. Thick crusts were seen involving the entire scalp. Laboratory investigations and histopathology were suggestive of neutrophilic dermatoses (Sweet's syndrome).

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Neonatal Sweet syndrome with associated rectovestibular fistula and review of the literature

Abdelwahab,

Coias,

Tollefson

2024

Pediatric Dermatology

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An otherwise healthy 4‐week‐old term female of Japanese heritage presented with a 1‐week history of asymptomatic progressive, generalized skin lesions. The lesion morphology, distribution, and dermatopathology result was consistent with Sweet syndrome. The patient was found to have a congenital type H rectovestibular fistula. This case highlights the rare association of rectovestibular fistula in neonatal Sweet syndrome which has only been described in neonates of Japanese heritage.

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Neonatal lupus erythematosus or Sweet syndrome?

Cited by 3 publications

References 14 publications

Neonatal lupus erythematosus presenting as a non‐bullous histiocytoid neutrophilic dermatosis

Neonatal lupus erythematosus presenting as a non‐bullous histiocytoid neutrophilic dermatosis

A case of infantile Sweet’s syndrome

Neonatal Sweet syndrome with associated rectovestibular fistula and review of the literature

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