2012
DOI: 10.1155/2012/301274
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Neonatal Lupus Erythematosus

Abstract: Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may… Show more

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Cited by 62 publications
(65 citation statements)
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“…Hydrocephaly, calcification of the basal ganglia, and vasculopathy are also reported (10). Hematologic findings including hemolytic anemia, thrombocytopenia, and leukopenia are other transient manifestations (2,11).…”
Section: Discussionmentioning
confidence: 99%
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“…Hydrocephaly, calcification of the basal ganglia, and vasculopathy are also reported (10). Hematologic findings including hemolytic anemia, thrombocytopenia, and leukopenia are other transient manifestations (2,11).…”
Section: Discussionmentioning
confidence: 99%
“…Although dermatological manifestations commonly occur in exposed areas after sun exposure, it may also be seen immediately after birth without any sun exposure (2). This manifestation is transient and rarely leaves atrophic scars (2). Cardiac disease with third-degree heart block is the most common cardiac manifestation, however, the other less common manifestations are myocarditis, cardiomyopathy often with endocardial fibroelastosis, and valvular lesions causing stenosis, regurgitation, and dysplasia due to inflammation and fibrosis (1).…”
Section: Discussionmentioning
confidence: 99%
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“…The 52-kD Ro/SSA ribo-nucleoprotein is strongly linked in the autoimmune response in mothers whose children have congenital heart block. 16 These autoantibodies antagonize the serotonin-induced L-type calcium channel activation on human fetal atrial cells and trigger an inflammatory, leading to fibrosis and scarring of the atrioventricular node, sinus node, and His bundle. This explains the electrophysiological abnormalities of the cardiac rhythm disturbances, which may lead to the subsequent congestive heart failure.…”
Section: Clinical Presentationsmentioning
confidence: 99%
“…Kardiyak tutulum %20 mortal seyretmekte ve kalp bloğu olan NLE'li hastalarda %57-66 oranında "pacemaker" gerekmektedir. 2,3,6,8,9 Olgumuzun kardiyak muayenesi, ayrıca elektrokardiyografi ve ekokardiyografi incelemesi normal olarak değerlendirildi ve klinik takibe alındı. NLE'de sistemik olarak karaciğer tutulumu ve hematolojik anormallikler yaklaşık %10 oranında görülmektedir.…”
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