Neonatal–maternal factors and perfluoroalkyl substances in cord blood

Lien, Guang-Wen; Huang, Chin‐Cheng; K, Wu; Chen, Mei-Huei; Lin, Chien‐Yu; Chen, Chia-Yang; Hsieh, Wu‐Shiun; Chen, Pau‐Chung

doi:10.1016/j.chemosphere.2013.04.038

Cited by 40 publications

(58 citation statements)

References 58 publications

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“…It is known that PFOS can cross placenta and through lactation to impose developmental effects on fetus and neonates [25], [31], [36]–[40]. To investigate if the increase of liver weight might cause disturbance to liver functions as reported in the toxicological models in adult animals [22], [23], [26], [41], [42], the mRNA expression levels of hepatic genes targeting lipid metabolism were measured in the F 1 pups and were found to be modulated.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Exposure to Perfluorooctane Sulfonate Affects Glucose Metabolism in Adult Offspring

et al. 2014

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Perfluoroalkyl acids (PFAAs) are globally present in the environment and are widely distributed in human populations and wildlife. The chemicals are ubiquitous in human body fluids and have a long serum elimination half-life. The notorious member of PFAAs, perfluorooctane sulfonate (PFOS) is prioritized as a global concerning chemical at the Stockholm Convention in 2009, due to its harmful effects in mammals and aquatic organisms. PFOS is known to affect lipid metabolism in adults and was found to be able to cross human placenta. However the effects of in utero exposure to the susceptibility of metabolic disorders in offspring have not yet been elucidated. In this study, pregnant CD-1 mice (F0) were fed with 0, 0.3 or 3 mg PFOS/kg body weight/day in corn oil by oral gavage daily throughout gestational and lactation periods. We investigated the immediate effects of perinatal exposure to PFOS on glucose metabolism in both maternal and offspring after weaning (PND 21). To determine if the perinatal exposure predisposes the risk for metabolic disorder to the offspring, weaned animals without further PFOS exposure, were fed with either standard or high-fat diet until PND 63. Fasting glucose and insulin levels were measured while HOMA-IR index and glucose AUCs were reported. Our data illustrated the first time the effects of the environmental equivalent dose of PFOS exposure on the disturbance of glucose metabolism in F1 pups and F1 adults at PND 21 and 63, respectively. Although the biological effects of PFOS on the elevated levels of fasting serum glucose and insulin levels were observed in both pups and adults of F1, the phenotypes of insulin resistance and glucose intolerance were only evident in the F1 adults. The effects were exacerbated under HFD, highlighting the synergistic action at postnatal growth on the development of metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Perinatal Exposure to Perfluorooctane Sulfonate Affects Glucose Metabolism in Adult Offspring

et al. 2014

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“…Berg et al also found that age was positively associated with maternal PFNA, PFDA, and PFUnDA levels [ 6 ]. Moreover, Lee et al found that PFOS levels in the breast milk were also positively associated with age [ 34 ]; Lien et al also reported that cord blood showed a positive association with maternal age from different kinds of specimens [ 35 ]. However, Ode et al found no association between maternal PFAS levels and maternal age [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…We found that compared to the C11-C13, C6-C10 PFAS were significantly negatively associated with parity. According to published papers, most studies found that first pregnancy or nulliparity was associated with higher maternal PFAS levels [ 6 , 23 , 25 , 26 , 36 , 38 ], cord blood PFAS levels [ 35 ] and breast milk PFAS levels [ 34 ]. PFAS may be transferred to infants or to the placenta through the umbilical cord [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children’s Health

Tsai

Miyashita

Araki

et al. 2018

IJERPH

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Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental and consumer products, which depend on human lifestyle, socioeconomic characteristics, and time variation. Here, we aimed to explore the temporal trends of PFAS in pregnant women and the characteristics related to maternal PFAS concentration. Our study is part of the Hokkaido Study on Environment and Children’s Health, the Hokkaido large-scale cohort that recruited pregnant women between 2003 and 2011. Blood samples were acquired from pregnant women during the third trimester to measure PFAS and cotinine concentrations. Maternal basic information was collected with a baseline structured questionnaire. Eleven PFAS were measured from 2123 samples with ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Eight PFAS were above 80% detection rate and were included in the final analysis. We used multivariable linear regression to analyze the association of pregnant women characteristics with the levels of eight PFAS. The temporal trend of PFAS was observed in two periods (August 2003 to January 2006 and February 2006 to July 2012). The concentration of perfluorooctane sulfonate (PFOS) significantly decreased from August 2003 to January 2006 and from February 2006 to July 2012. The concentrations of perfluorododecanoic acid (PFDoDA), perfluoroundecanoic acid (PFUnDA), and perfluorotridecanoic acid (PFTrDA) increased significantly between August 2003 and January 2006, whereas they decreased significantly between February 2006 and July 2012. Women with pre-pregnancy body mass index (BMI) >25 kg/m2 had lower PFUnDA, PFDoDA, and PFTrDA levels than did those with normal BMI (18.5–24.9 kg/m2). Pregnant women, who were active smokers (cotinine > 11.49 ng/mL), had higher PFOS than the non-smokers (cotinine < 0.22 ng/mL). Lower levels of PFHxS, PFOS, PFOA, PFNA, and PFDA were observed in women, who had given birth to more than one child. There were also significant positive associations between PFAS levels and annual income or maternal education. PFAS levels varied in women with higher pre-pregnancy BMI, active smoking status, higher education level and annual income. The causes of the individual PFAS differences should be explored in an independent study.

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“…PFAAs cross the placental barrier, exposing neonates via their mother's blood [26, [174][175][176][177][178][179][180][181][182][183][184]. PFOS and PFCAs are generally in lower concentrations in cord serum than in maternal serum [174].…”

Section: Human Exposurementioning

confidence: 99%