Neonatal Maternal Separation Alters Immune, Endocrine, and Behavioral Responses to Acute Theiler’s Virus Infection in Adult Mice

Meagher, Mary W.; Sieve, Amy N.; Johnson, Robin; Satterlee, Danielle Marie; Belyavskyi, Michail; Mi, Wentao; Prentice, Thomas W.; Welsh, T. H.; Welsh, C. Jane

doi:10.1007/s10519-010-9333-5

Cited by 42 publications

(34 citation statements)

References 120 publications

(207 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many researchers have found differences between MS mice and non-separated/handled controls (Avitsur and Sheridan 2009;Boasen et al 2009;Cruz et al 2008;Kiank et al 2009;Meagher et al 2010;Navailles et al 2010;van Heerden et al 2009;Veenema et al 2008;Wei et al 2010). However, a study of eight different mouse strains subjected to MS and compared with regard to prepulse inhibition (PPI) of the acoustic startle response (an impairment in sensorimotor gating found in schizophrenic patients) were found to have marked differences across strains (Millstein et al 2006).…”

Section: ↑=Increased ↓=Decreased ↕=Alternatingmentioning

confidence: 99%

Maternal separation as a model of brain–gut axis dysfunction

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: ↑=Increased ↓=Decreased ↕=Alternatingmentioning

confidence: 99%

Maternal separation as a model of brain–gut axis dysfunction

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that immunodevelopment occurs on a different timeline in males and females (Rana et al, 2012), and that MS can impact persistence of HPA reactivity in a sex-specific manner (Meagher et al, 2010). Therefore, developmental differences in the immune environment, such as circulating cytokine expression may serve to better identify individuals at an elevated risk to develop later cognitive deficits.…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that there would be a sex-specific effect on immune regulation as a function of early life stress. In this regard, there are only few studies addressing whether early life stress affects male and female immune responsivity differently (Avitsur et al, 2013; Avitsur et al, 2009; Meagher et al, 2010), with little known about baseline differences in immune regulators. In the present study, we sought to identify sex- and age-specific relationships between juvenile cytokine levels, adolescent cognitive performance, and adolescent mPFC PVB expression.…”

Section: Introductionmentioning

confidence: 99%

Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines

Grassi‐Oliveira

Ganguly

Holland

et al. 2016

Psychoneuroendocrinology

View full text Add to dashboard Cite

Childhood adversity increases vulnerability to psychiatric disorders that emerge in adolescence, in a sex-dependent manner. Early adversity modeled in rodents with maternal separation (MS) affects cognition and medial prefrontal cortex (mPFC) circuitry. Humans and animals exposed to early life adversity also display heightened circulating inflammatory cytokines, however the predictive relationship of these early measures with later behavioral deficits is unknown. Here, male and female rats were exposed to MS or control rearing during the postnatal period (P2–21). Blood samples were taken at distinct developmental time points for analysis of the pro-inflammatory cytokine IL-1β and the anti-inflammatory cytokines IL-4, and IL-10, followed by win-shift cognitive testing and analysis of mPFC parvalbumin (PVB) immunofluorescent interneurons in adolescence. Regression analyses were conducted to explore the relationship between early cytokines and adolescent behavioral measures. We observed sex- and age-dependent effects of MS on circulating cytokines. MS also yielded adolescent decreases in mPFC PVB and cognitive deficits, which were predicted by early cytokine expression in a sex- and experience-dependent manner. Taken together, the present data reveals that circulating cytokines and PVB levels are predictive of adolescent cognitive deficits, and therefore provide compelling evidence for a putative role of early biomarkers in mediating MS-induced behavioral dysfunction. Importantly, predictive relationships often depended on sex and on MS history, suggesting that early life experiences may yield individualistic mechanisms of vulnerability compared to the general population.

show abstract

“…A variety of psychosocial and physiological factors have been shown to affect susceptibility to viral infection (Avitsur et al, 2006; Meagher et al, 2010). One of the key factors implicated in modulating disease severity is the exposure to chronic stressors.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the response to influenza virus infection: Modulation by stress

Avitsur

Mays

Sheridan

2011

Hormones and Behavior

View full text Add to dashboard Cite

Influenza virus infection is a significant public health problem; however factors affecting the incidence and severity of disease have not been fully elucidated. The present study sought to examine the role of sex and stress in mediating susceptibility to an influenza viral infection in mice. Male and female mice underwent repeated cycles of restraint (RST) stress, followed by an influenza A/PR8 virus infection. Following these manipulations, levels of circulating corticosterone, lung proinflammatory cytokine gene expression and sickness behavior were examined. The data indicate sex differences in several aspects of the response to the A/PR8 virus infection. The kinetics of lung interleukin-1β mRNA expression were faster in infected males compared to females, while circulating corticosterone levels were elevated in infected females, but not in males. Anorexia and reduced saccharin consumption began earlier and symptoms were more pronounced in infected males than in females. In addition, RST modulated the response to the A/PR8 virus infection. Proinflammatory cytokine gene expression in response to infection was enhanced and sickness behavior was modulated by RST in both males and females. These data suggest that males mount more vigorous immune and behavioral responses to influenza viral infection compared to females, and stress exacerbates the response in both males and females. In conclusion, complex interactions between biological and behavioral factors are involved in mediating individual differences in health and disease. Additional studies may help uncover some of the factors contributing to the individual differences in susceptibility to influenza infection.

show abstract

Neonatal Maternal Separation Alters Immune, Endocrine, and Behavioral Responses to Acute Theiler’s Virus Infection in Adult Mice

Cited by 42 publications

References 120 publications

Maternal separation as a model of brain–gut axis dysfunction

Maternal separation as a model of brain–gut axis dysfunction

Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines

Sex differences in the response to influenza virus infection: Modulation by stress

Contact Info

Product

Resources

About