Neonatal morbidity mortality outcomes in pre-term premature rupture of membranes

Abstract

We present a retrospective review of 228 pre-term premature rupture of membranes (PPROM) singleton pregnancies followed-up in our clinic between 1996 and 2005. The most common neonatal morbidities in PPROM cases are respiratory distress syndrome (RDS), sepsis and intraventricular haemorrhage (IVH). The route of delivery does not affect newborn intensive care unit (NICU) requirements, perinatal asphyxia, sepsis and IVH rates in PPROM cases. NICU and PPV requirements, RDS, sepsis and IVH rates increase if the Apgar score is < 5. Neonatal morbidity and mortality rates increase as the latent period lengthens. C reactive protein (CRP) on admission, last CRP, birth weight and the 5 min Apgar score was found to be associated with NICU requirements; only the 5 min Apgar score was found to be associated with RDS; and last leukocyte count and maternal haemotocrit was found to be associated with sepsis and pneumonia, independently. In PPROM cases, CRP on admission, last CRP, birth weight, the 5 min Apgar score, last leukocyte count and maternal haemotocrit, should be considered to predict neonatal outcomes.

Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome

“…Linehan et al analyzed the neonatal and maternal outcome in women after PPROM, diagnosed between 14 and 23 + 6 weeks' gestation: only 23% of infants were born alive and the overall mortality rate was 95% [88][89][90]. In this study chorioamnionitis was found in 69% and 12% patients developed post-partum hemorrhage [88].…”

Inducción del parto versus manejo expectante en ruptura prematura de membranas pretérmino: revisión sistemática y metanálisis

“…La PPROM es considerada actualmente como el principal agente causal del 30% de los partos pretérmino 4 , representando un alto riesgo de morbilidad fetal y una alta tasa de hospitalización asociada en el primer mes de vida comparados con los recién nacidos a término 5 . Asimismo, genera un aumento en la posibilidad de producir efectos adversos en el desarrollo fetal secundario a un estado de oligoamnios prolongado 6 . En Colombia, durante el año 2014, según estadísticas del Departamento Administrativo Nacional de Estadística (DANE), el 19% de los partos fueron pretérmino de los cuales el 9% se asoció a mortalidad fetal 7 .…”

Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review

“…Conditions due to prematurity include respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), necrotising enterocolitis (NEC), a prolonged stay in the neonatal intensive care unit (NICU), neonatal sepsis, required use of positive pressure ventilation (PPV), cardiac abnormalities, hyperbilirubinemia and hemolytic anemia, as well as cerebral palsy, and other long-term outcomes (4). Therefore, appropriate management of PPROM is crucial to improving neonatal and maternal outcomes.…”