1980
DOI: 10.1542/peds.66.6.928
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Neonatal Necrotizing Enterocolitis Associated with Penicillin-Resistant, Toxigenic Clostridium butyricum

Abstract: The cause of neonatal necrotizing enterocolitis (NEC) is unknown. An association between NEC and clostridial infection has been reported from several centers, but the organisms have not been extensively characterized. Clostridium butyricum was isolated from the peritoneal fluid and cerebrospinal fluid of a neonate with NEC. The organism was resistant to the penicillins, but sensitive to vancomycin. Toxin production was demonstrated. Although the role of clostridial toxins in the pathogenesis of NEC is unknown,… Show more

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Cited by 54 publications
(4 citation statements)
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“…In those infected with Clostridium perfringens, the disease was fulminant with extensive pneumatosis intestinalis, gangrene, perforation, and death [29]. Clostridium butyricum has also been found during an outbreak of NEC [30]; and although the role of clostridial toxins is uncertain, an association of toxigenic C. butyricum and NEC bas been reported [31]. In addition, an etiologic role of Clostridium difficile has been documented in an outbreak of NEC by the detecting C. difficile cytotoxin in the stools of 12 of 13 affected infants and isolating the organism in 8 (61.5%) [32].…”
Section: Clostridiamentioning
confidence: 99%
“…In those infected with Clostridium perfringens, the disease was fulminant with extensive pneumatosis intestinalis, gangrene, perforation, and death [29]. Clostridium butyricum has also been found during an outbreak of NEC [30]; and although the role of clostridial toxins is uncertain, an association of toxigenic C. butyricum and NEC bas been reported [31]. In addition, an etiologic role of Clostridium difficile has been documented in an outbreak of NEC by the detecting C. difficile cytotoxin in the stools of 12 of 13 affected infants and isolating the organism in 8 (61.5%) [32].…”
Section: Clostridiamentioning
confidence: 99%
“…4, No. 4,1985 isolated frequently from babies with NEC and has been suggested as a primary cause of the disease, although it is not known to be toxigenic (23). It could, however, play an important synergistic role since it produces a beta-lactamase capable of destroying penicillin (24).…”
Section: Discussionmentioning
confidence: 99%
“…Neonatal necrotizing enterocolitis occurs in premature babies. The most likely cause of the disease is infection of C. butyricum [158][159][160]. Symptoms caused by small bowel necrosis include poor feeding, bloating, decreased activity, blood in the stool, or vomiting of bile.…”
Section: Clostridium Butyricum-induced Necrotizing Enteritismentioning
confidence: 99%