Neonatal Nucleated Red Blood Cells in Infants of Overweight and Obese Mothers

Sheffer-Mimouni, Galit; Mimouni, Francis; Dollberg, Shaul; Mandel, Dror; Deutsch, Varda; Littner, Yoav

doi:10.1080/07315724.2007.10719609

Cited by 12 publications

(11 citation statements)

References 29 publications

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“…25,26 In a previous study, we reported that infants of overweight and obese mothers have increased circulating absolute nucleated red blood cells counts at birth compared with infants of non-obese mothers. 6 The current findings support our theory that elevation of circulating absolute nucleated red blood cells counts in infants of overweight and obese mothers was due to increased production of fetal EPO. This theory is also supported by the fact that infants of obese mothers are at a higher risk for intrauterine fetal death.…”

Section: Discussionsupporting

confidence: 88%

“…[3][4][5] In a previous study, we reported that infants of overweight and obese mothers have increased circulating absolute nucleated red blood cell counts at birth compared with infants of non-obese mothers. 6 We then speculated that fetal hypoxia was responsible for both the elevation of circulating absolute nucleated red blood cells (through increased production of fetal erythropoietin (EPO)) and the elevated risk for 'unexplained' intrauterine fetal death.We thus designed this study to examine the hypothesis that maternal body mass index (BMI) (an index of maternal adiposity) correlates with cord blood concentrations of EPO. …”

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confidence: 99%

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Effect of maternal body mass index on cord blood erthropoietin concentrations

et al. 2014

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Section: Discussionsupporting

confidence: 88%

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confidence: 99%

Effect of maternal body mass index on cord blood erthropoietin concentrations

et al. 2014

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“…In rodents, hypoxia downregulates MME expression in the lungs, kidneys [20], and in the brain [21]. In fact, several studies have revealed a subtle hypoxic fetal environment in pregnancy complicated by maternal overweight [29,30]. Additionally, MME is downregulated by NF-κB pathway via microRNA miR155 in B-lymphoma cells [31].…”

Section: Discussionmentioning

confidence: 99%

Maternal Overweight Downregulates MME (Neprilysin) in Feto-Placental Endothelial Cells and in Cord Blood

Weiss

Berger

Brandl

et al. 2020

IJMS

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Maternal overweight in pregnancy alters the metabolic environment and generates chronic low-grade inflammation. This affects fetal development and programs the offspring’s health for developing cardiovascular and metabolic disease later in life. MME (membrane-metalloendopeptidase, neprilysin) cleaves various peptides regulating vascular tone. Endothelial cells express membrane-bound and soluble MME. In adults, the metabolic environment of overweight and obesity upregulates endothelial and circulating MME. We here hypothesized that maternal overweight increases MME in the feto-placental endothelium. We used primary feto-placental endothelial cells (fpEC) isolated from placentas after normal vs. overweight pregnancies and determined MME mRNA, protein, and release. Additionally, soluble cord blood MME was analyzed. The effect of oxygen and tumor necrosis factor α (TNFα) on MME protein in fpEC was investigated in vitro. Maternal overweight reduced MME mRNA (−39.9%, p < 0.05), protein (−42.5%, p = 0.02), and MME release from fpEC (−64.7%, p = 0.02). Both cellular and released MME protein negatively correlated with maternal pre-pregnancy BMI. Similarly, cord blood MME was negatively associated with pre-pregnancy BMI (r = −0.42, p = 0.02). However, hypoxia and TNFα, potential negative regulators of MME expression, did not affect MME protein. Reduction of MME protein in fpEC and in cord blood may alter the balance of vasoactive peptides. Our study highlights the fetal susceptibility to maternal metabolism and inflammatory state.

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“…We then conducted a backward stepwise regression analysis to assess whether EPO (dependent variable) could be influenced by the duration of ruptured membranes while taking into account possible confounding variables such as gestational age, 1-or 5-minute Apgar scores, or maternal body mass index (BMI). 14 In this analysis again, EPO was not influenced by duration of ruptured membranes and only maternal BMI was weakly, but…”

Section: Resultsmentioning

confidence: 58%