Neonatal ocular prophylaxis in the United States: is it still necessary?

Franco, Susannah; Hammerschlag, Margaret R.

doi:10.1080/14787210.2023.2172401

Cited by 8 publications

(10 citation statements)

References 40 publications

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“…In addition to topical ocular prophylaxis, 2 guidelines 21,24 recommended prenatal screening and treatment of pregnant women are also important in preventing neonatal conjunctivitis, which is also demonstrated by studies [26][27][28] . In clinical practice, the Canadian Pediatric Society, the CDC from the United States, and NICE from the UK all advocated prenatal screening and treatment 7 . Screening is recommended at the first prenatal visit and again in the third trimester or at birth for those who were not screened before or had no prenatal care 3,19,24 .…”

Section: Discussionmentioning

confidence: 99%

“…However, over the past 2 decades, universal topical ocular prophylaxis for preventing neonatal ophthalmia has been controversial [7][8][9] . One perspective is that ocular prophylaxis for neonates at birth can effectively prevent further infections 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Among these, chlamydial ophthalmia has the highest prevalence 4 , but gonococcal ophthalmia poses greater harm to infants as it can progress to corneal perforation or blindness within a few days if left untreated 6 . The incidence of neonatal ophthalmia has sharply decreased since the introduction of ocular prevention with silver nitrate by Credé in the 1880s 7 . Since then, topical ocular prophylaxis has played an important role in preventing neonatal conjunctivitis.…”

Section: Introductionmentioning

confidence: 99%

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A review of clinical practice guidelines for preventing chlamydial and gonococcal ophthalmia neonatorum

Sun

Zhu

Zhang³

et al. 2023

Interdisciplinary Nursing Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A review of clinical practice guidelines for preventing chlamydial and gonococcal ophthalmia neonatorum

Sun

Zhu

Zhang³

et al. 2023

Interdisciplinary Nursing Research

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“…30 Similar practices have also made STIassociated ophthalmia neonatorum a rare occurrence in Canada and in Western Europe. 31,32 Sub-Saharan Africa. In many sub-Saharan African regions, N. gonorrhoeae and C. trachomatis, the major pathogens implicated in ocular morbidity, are highly prevalent in pregnant women with frequencies of either infection as high as 31%.…”

Section: History and Etiology Of Ophthalmia Neonatorummentioning

confidence: 99%

“…30 Similar practices have also made STI-associated ophthalmia neonatorum a rare occurrence in Canada and in Western Europe. 31,32…”

Section: Evidence Reviewmentioning

confidence: 99%

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana

et al. 2023

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Background We describe 12 cases of chlamydial ophthalmia neonatorum and the current scientific evidence on its prevention and treatment. The data presented were obtained from the “Maduo” study, a prospective observational study of the relationship between curable sexually transmitted infections and adverse neonatal outcomes at four antenatal clinics in Gaborone, Botswana. Methods Infants of mothers with perinatal chlamydia infection were evaluated for chlamydial ophthalmia neonatorum based on clinical presentation of conjunctivitis or positive test via GeneXpert CT/NG assay. Data on 29 infants born to mothers with postnatal C. trachomatis infection were analysed. Results 12 infants were diagnosed with chlamydial ophthalmia neonatorum. Eight of those cases were confirmed with the GeneXpert CT/NG assay while four were identified as probable cases based on clinical history and presentation. Overall, nine infants presented with signs of conjunctivitis, while three who had a positive diagnostic test result had asymptomatic infection. All but one infant had received ocular 1% tetracycline prophylaxis at birth, and four infants had signs suggestive of chlamydial pneumonia at presentation. Two out of five symptomatic cases whose mothers reported completion of their treatment course with erythromycin had lingering symptoms. Conclusions Our findings affirm that the current prophylaxis and treatment modalities for chlamydial ophthalmia neonatorum are inadequate. To the extent feasible in low- and middle-income countries, we recommend implementation of routine C. trachomatis screening and treatment in pregnant women.

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Striving Toward Better Eye Health Beyond Our Waiting Rooms: The LXXX Edward Jackson Memorial Lecture

Higginbotham

2024

American Journal of Ophthalmology

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Neonatal ocular prophylaxis in the United States: is it still necessary?

Cited by 8 publications

References 40 publications

A review of clinical practice guidelines for preventing chlamydial and gonococcal ophthalmia neonatorum

A review of clinical practice guidelines for preventing chlamydial and gonococcal ophthalmia neonatorum

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana

Striving Toward Better Eye Health Beyond Our Waiting Rooms: The LXXX Edward Jackson Memorial Lecture

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