Neonatal outcome of congenital ventriculomegaly

McKechnie, Liz; Vasudevan, Chakrapani; Levene, Malcolm I.

doi:10.1016/j.siny.2012.06.001

Cited by 55 publications

(32 citation statements)

References 23 publications

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“…In assessing ventriculomegaly, distinguishing between obstructive and nonobstructive causes requires evaluation of all 4 components of the ventricular system. This distinction is crucial in understanding the etiology, treatment, and outcomes for the fetus with ventriculomegaly [44,45] . Accurate classification of the fourth ventricle in relation to hindbrain parenchymal volume is also necessary to better identify and diagnose pathologic and nonpathologic posterior fossa fluid collections.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Andescavage¹,

duPlessis

McCarter

et al. 2016

Dev Neurosci

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Objective: The objective of this study was to apply quantitative magnetic resonance imaging to characterize absolute cerebrospinal fluid (CSF) development, as well as its relative development to fetal brain parenchyma in the healthy human fetus. Design: We created three-dimensional high-resolution reconstructions of the developing brain for healthy fetuses between 18 and 40 weeks' gestation, segmented the parenchymal and CSF spaces, and calculated the volumes for the lateral, third, and fourth ventricles; extra-axial CSF space; and the cerebrum, cerebellum, and brainstem. From these data, we constructed normograms of the resulting volumes according to gestational age and described the relative development of CSF to fetal brain parenchyma. Results: Each CSF space demonstrated major increases in volumetric growth during the second half of gestation: third ventricle (23-fold), extra-axial CSF (11-fold), fourth ventricle (8-fold), and lateral ventricle (2-fold). Total CSF volume was related to total brain volume (p < 0.01), as was lateral ventricle to cerebral volume (p < 0.01); however, the fourth ventricle was not related to cerebellar or brainstem volume (p = 0.18-0.19). Relevance: Abnormalities of the CSF spaces are the most common anomalies of neurologic development detected on fetal screening using neurosonography. Normative values of absolute CSF volume, as well as relative growth in comparison to intracranial parenchyma, provide valuable insight into normal fetal neurodevelopment. These data may provide important biomarkers of early deviations from normal growth, better distinguish between benign variants and early disease, and serve as reference standards for postnatal growth and development in the premature infant.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Andescavage¹,

duPlessis

McCarter

et al. 2016

Dev Neurosci

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“…Hydrocephalus has been considered a CNS condition consisting of a net accumulation of intraventricular or extraventricular CSF independent of hydrostatic or barometric pressure. The increase in CSF volume causes an enlargement of the ventricular cavities, i.e., ventriculomegaly 9 . Regarding the circulation of CSF, different forms of hydrocephalus have been grouped as non-communicating or communicating 10 .…”

Section: Purpose Of the Reviewmentioning

confidence: 99%

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

et al. 2014

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The neuroepithelium is a germinal epithelium containing progenitor cells that produce almost all of the central nervous system cells, including the ependyma. The neuroepithelium and ependyma constitute barriers containing polarized cells covering the embryonic or mature brain ventricles, respectively; therefore, they separate the cerebrospinal fluid that fills cavities from the developing or mature brain parenchyma. As barriers, the neuroepithelium and ependyma play key roles in the central nervous system development processes and physiology. These roles depend on mechanisms related to cell polarity, sensory primary cilia, motile cilia, tight junctions, adherens junctions and gap junctions, machinery for endocytosis and molecule secretion, and water channels. Here, the role of both barriers related to the development of diseases, such as neural tube defects, ciliary dyskinesia, and hydrocephalus, is reviewed.

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“…Konnataler Hydrozephalus und Vena Galeni-Malformation ▼ Eine Erweiterung der internen Liquorräume kommt mit einer Häufi gkeit von ca. 2:1 000 Lebendgeborenen vor [ 57 ] . Eine Ventrikelweite von 10-12 mm wird als milde, zwischen 12-15 als moderate und > 15 mm als schwere Ventrikulomegalie defi niert [ 57 ] .…”

Section: Besonderheiten Bei Der Erstversorgungunclassified

Geburtsplanung bei fetalen Fehlbildungen aus neonatologischer Sicht

Werlein

Goebert

Maier

2014

Z Geburtshilfe Neonatol

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Nowadays, most major congenital malformations are detected by prenatal ultrasound long before birth. This offers the opportunity to plan and organise the birth of such a baby in the most favourable setting. This paper gives an overview about how to decide on place, timing, and mode of delivery in some typical congenital malformations from the neonatologist's point of view. As, in most cases scientific evidence is lacking, there is an urgent need for prospective clinical trials. The question concerning the best place of birth is answered in a national guideline, which has been consented by several scientific societies. In this guideline, the transfer of the pregnant woman to a high level perinatal centre is recommended in the case of a known foetal malformation. Delivery outside a perinatal centre has been shown to increase mortality in infants with congenital diaphragmatic hernia and complications in infants born with gastroschisis. With respect to the timing of the delivery, the risks of an iatrogenic preterm birth must be considered in relation to the potential benefit for the newborn baby. There seems to be some advantage of a birth before the regular date only in few malformations. In most cases of congenital malformation, only a Caesarean section has a remarkable advantage with respect to the organisation of the delivery room management, but has no medical necessity for the baby. In summary, the delivery of a baby with a congenital malformation should be planned and organised by an interdisciplinary team of prenatal and postnatal specialists in close contact and consent with the parents.

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Neonatal outcome of congenital ventriculomegaly

Cited by 55 publications

References 23 publications

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

Geburtsplanung bei fetalen Fehlbildungen aus neonatologischer Sicht

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