Neonatal outcomes are associated with latency after preterm premature rupture of membranes

Nayot, Dan; Penava, Debbie; Silva, O Da; Richardson, Bryan; Vrijer, Barbra de

doi:10.1038/jp.2012.15

Cited by 34 publications

(36 citation statements)

References 37 publications

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“…A retrospective study reported that length of pregnancy at PPROM, twin gestation, and oligohydramnios were associated with the latency period . However, PPROM pathophysiology was not considered in either of these studies . The present study identified oxidative stress and inflammatory response as being associated with PPROM.…”

Section: Discussionmentioning

confidence: 56%

“…Neonatal outcomes have been demonstrated to be associated with latency after PPROM . Predicting latency could be useful when delivery is planned to take place in a tertiary hospital.…”

Section: Discussionmentioning

confidence: 99%

“…The latency between PPROM and delivery has been demonstrated to be associated with neonatal outcomes and several factors, such as pregnancy duration at PPROM, twin pregnancy, and oligohydramnios, have been reported as affecting latency following PPROM . However, no data are available on the effects of inflammatory and oxidative stress markers on delivery latency among patients with PPROM.…”

Section: Introductionmentioning

confidence: 99%

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Maternal c‐reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes

Ryu

Moon

Heo

et al. 2016

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 56%

“…Neonatal outcomes have been demonstrated to be associated with latency after PPROM . Predicting latency could be useful when delivery is planned to take place in a tertiary hospital.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal c‐reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes

Ryu

Moon

Heo

et al. 2016

Intl J Gynecology & Obste

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“…Similar results that a prolonged duration of membrane rupture of more than 48-168 hours has significant influence on the development of chorioamnionitis were found by other researchers as well (37)(38). There were certain studies suggesting that prolonged duration of the membrane rupture period is associated with decreasing risk of newborn's illnesses and the duration of the membrane rupture period is decreasing when there is an increase of gestational age (39)(40).…”

Section: Discussionmentioning

confidence: 99%

Preterm premature rupture of membranes at 32–34 weeks of gestation: duration of membrane rupture period and maternal blood indicators relation with congenital infection

Daunoravičienė¹,

Musteikytė²,

Ramašauskaitė³

2015

AML

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Background. The study investigates the influence of the length of membrane rupture period among pregnant women with preterm premature rupture of membranes (PPROM) between the 32nd and 34th weeks of gestation on the development of chorioamnionitis and the congenital infection of a newborn. It seeks to ascertain the values of indicators in mother's blood that enable to predict chorioamnionitis and funisitis for mothers, and congenital infection for newborns.Materials and methods. A retrospective study of case records of women with PPROM at 32 (32 w. + 0 d)-34 (33 w. + 6 d) weeks of gestation and their newborns was performed. Two comparative groups were made: 1) of women who had funisitis and / or chorioamnionitis with or without deciduitis and 2) of women having no proved inflammation (according to the results of histological examination of placentae). Analogically, comparative groups were made of their newborns: those who had diagnosis of congenital infection and those who had no infection. The duration of membrane rupture period and the blood markers were investigated in all the groups.Results. The study included 135 women. Duration of the membrane rupture period lasted 85.17 ± 84.72 hrs in the group of women who had histological inflammation, and 40.06 ± 56.57 hrs in the group with no inflammation, P = 0.01, AUC = 0.735; the critical membrane rupture period value for developing intrauterine infection by the Youden index was 43.7 hrs. The corresponding maternal CRP values (mg/l) were 25.85 ± 40.27 vs. 5.23 ± 7.88 (P = 0.01, AUC = 0.6), the Youden index 4.6 mg/l. For the mothers of the newborns diagnosed with infection, the duration of the membrane rupture period was 55.95 ± 65.04 hrs, for the mothers of the newborns without congenital infection it was 40.25 ± 73.71 hours. Respectively, CRP values for the mothers of newborns averaged 12.25 ± 22.14 mg/l vs. 4.8 ± 4.82 mg/l (P = 0.005).Conclusions. Longer membrane rupture period and higher maternal CRP are correlated with inflammatory changes in the placenta and umbilical cord, thus they can be used as the prognostic indicators of intrauterine infection. When the duration of the membrane rupture period lasts ≥44 hrs, the risk of chorioamnionitis and funisitis increases five times; when the maternal serum CRP is higher than 5 mg/l, funisitis / chorioamnionitis is twice more frequent than at lower than 5 mg/l CRP values.

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“…In another study, the rate of RDS decreased and the rate of perinatal corticosteroid administration increased with time after PROM …”

Section: Discussionmentioning

confidence: 92%

Premature rupture of membranes and neonatal respiratory morbidity at 32–41 weeks’ gestation: A retrospective single‐center cohort study

Shimokaze

Akaba

Banzai

et al. 2015

J of Obstet and Gynaecol

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Aim: To ascertain whether premature rupture of membranes (PROM) independently affects the risk of neonatal respiratory morbidity at 32-41 weeks' gestation because previous reports have given insufficient consideration to the mode of delivery and labor onset. Methods: Data on 4,629 consecutive singleton infants were retrospectively collected. Respiratory morbidity was limited to respiratory distress syndrome and transient tachypnea of the newborn, both of which are related to prematurity. Delivery modes were divided into four groups based on the existence of PROM and of labor onset, and the respiratory morbidity was examined according to the number of weeks of gestational age. Multivariate analysis including PROM and delivery mode was conducted to examine the association of respiratory morbidity. Results: Respiratory morbidity or a positive pressure requirement delivered after PROM and intact amniochorionic membranes accompanied by labor were similar at all weeks. Around 37 weeks, the absence of labor onset was associated with a risk of respiratory morbidity or positive pressure requirement. Significant respiratory risk was not associated with the incidence of PROM (adjusted odds ratio [aOR], 0.98; 95% confidence interval [CI], 0.52-1.83), interval from rupture to delivery (aOR, 1.00; 95% CI, 0.99-1.01), clinical chorioamnionitis, induction management, pregnancy-related complications, or neonatal sex. Delivery by Cesarean section and early gestational age presented a significant risk for respiratory morbidity. Conclusions: Neither PROM nor latency after PROM at 32-41 weeks affected neonatal respiratory morbidity. Avoiding Cesarean section instead of simply increasing the time to delivery may help to reduce respiratory morbidity.

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Neonatal outcomes are associated with latency after preterm premature rupture of membranes

Cited by 34 publications

References 37 publications

Maternal c‐reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes

Maternal c‐reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes

Preterm premature rupture of membranes at 32–34 weeks of gestation: duration of membrane rupture period and maternal blood indicators relation with congenital infection

Premature rupture of membranes and neonatal respiratory morbidity at 32–41 weeks’ gestation: A retrospective single‐center cohort study

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