Neonatal Outcomes of Critical Congenital Heart Defects: A Multicenter Epidemiological Study of Turkish Neonatal Society

Dilli, Dilek; Akduman, Hasan; Zenciroğlu, Ayşegül; Çetinkaya, Merih; Okur, Nilüfer; Turan, Özden; Özlü, Ferda; Çalkavur, Şebnem; Demirel, Gamze; Koksal, Nilgün; Çolak, Rüya; Örün, Utku Arman; Öztürk, Erkut; Gül, Özlem; Tokel, Niyazi Kürşad; Erdem, Sevcan; Meşe, Timur; Erdem, Abdullah; Bostan, Özlem Mehtap; Polat, Tuğçin Bora; Taşar, Mehmet; Hatemi, Ali Can; Doyurgan, Onur; Özkan, Murat; Avşar, Mustafa Kemal; Sarıosmanoğlu, Osman Nejat; Uğurlucan, Murat; Sığnak, Işık Şenkaya; Başaran, Murat

doi:10.1007/s00246-023-03362-z

Cited by 2 publications

(6 citation statements)

References 35 publications

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“…The most common genetic disorders/ congenital anomalies were chromosomal abnormalities, digestive system and musculoskeletal anomalies. Likewise, a recent multicenter study conducted in Turkey revealed a 21.4% incidence of extracardiac malformations in cases (n = 98) associated with CCHD mortality [22]. In our study, preterm birth, LBW, twin/triplet pregnancy, multiparity, old maternal age, low maternal educational level, cesarean birth and male gender were determined as the conditions associated with higher CCHD mortality rates.…”

Section: Discussionsupporting

confidence: 52%

“…Several factors linked to CCHD mortality have been documented in prior studies. The literature suggests that a low rate of prenatal diagnosis, hindrances to the termination of pregnancy (ToP), and delayed postnatal diagnoses may contribute to high mortality rates [ 14 , 15 , 22 ]. Similar challenges are believed to contribute to the high CCHD mortality observed in Türkiye.…”

Section: Discussionmentioning

confidence: 99%

“…Similar challenges are believed to contribute to the high CCHD mortality observed in Türkiye. Prenatal and postnatal early diagnosis rates in the country still fall short of the desired levels [ 19 , 22 , 31 , 32 ]. Although the MoH has issued recommendations and provided guidelines for neonatal pulse oximetry screening before hospital discharge, the procedure is not obligatory [ 27 , 31 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Although such advances improve survival in infants with CCHD, the mortality rate remains relatively high [8,10,[14][15][16][17][18]. Although there have been few local studies conducted in Turkey that reported high mortality rates for CCHD [19][20][21][22], there is currently no comprehensive national-level study evaluating CCHD mortality and related conditions. The aim of this study was to examine the prevalence and characteristics of infant mortality attributed to CCHD and to provide evidence for future preventive strategies.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of infant deaths associated with critical congenital heart diseases; 2018–2021, Türkiye

Çaylan,

Yalçin,

Tezel

et al. 2024

BMC Public Health

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Background The aim of this study was to examine the characteristics of infant mortality associated with critical congenital heart disease (CCHD). Methods In a cross-sectional study, data for the study were obtained through Death Notification System, Birth Notification System and Turkish Statistical Institute birth statistics. Results Of all infant deaths, 9.8% (4083) were associated with CCHD, and the infant mortality rate specific to CCHD was 8.8 per 10,000 live births. CCHD-related infant deaths accounted for 8.0% of all neonatal deaths, while the CCHD specific neonatal death rate was 4.6 per 10,000 live births. Of the deaths 21.7% occurred in the early neonatal, 30.3% in the late neonatal and 48.0% in the post neonatal period. Group 1 diseases accounted for 59.1% (n = 2415) of CCHD related infant deaths, 40.5% (n = 1652) were in Group 2 and 0.4% (n = 16) were in the unspecified group. Hypoplastic left heart syndrome was the most common CCHD among infant deaths (n = 1012; 24.8%). The highest CCHD related mortality rate was found in infants with preterm birth and low birth-weight while multiparity, maternal age ≥ 35 years, twin/triplet pregnancy, male gender, maternal education in secondary school and below, and cesarean delivery were also associated with higher CCHD related infant mortality rate. There was at least one non-cardiac congenital anomaly/genetic disorder in 26.1% of all cases. Conclusion CCHD holds a significant role in neonatal and infant mortality in Türkiye. To mitigate CCHD-related mortality rates, it is crucial to enhance prenatal diagnosis rates and promote widespread screening for neonatal CCHD.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of infant deaths associated with critical congenital heart diseases; 2018–2021, Türkiye

Çaylan,

Yalçin,

Tezel

et al. 2024

BMC Public Health

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In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

Nappi

2024

IJMS

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The use of next-generation sequencing has provided new insights into the causes and mechanisms of congenital heart disease (CHD). Examinations of the whole exome sequence have detected detrimental gene variations modifying single or contiguous nucleotides, which are characterised as pathogenic based on statistical assessments of families and correlations with congenital heart disease, elevated expression during heart development, and reductions in harmful protein-coding mutations in the general population. Patients with CHD and extracardiac abnormalities are enriched for gene classes meeting these criteria, supporting a common set of pathways in the organogenesis of CHDs. Single-cell transcriptomics data have revealed the expression of genes associated with CHD in specific cell types, and emerging evidence suggests that genetic mutations disrupt multicellular genes essential for cardiogenesis. Metrics and units are being tracked in whole-genome sequencing studies.

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Neonatal Outcomes of Critical Congenital Heart Defects: A Multicenter Epidemiological Study of Turkish Neonatal Society

Cited by 2 publications

References 35 publications

Investigation of infant deaths associated with critical congenital heart diseases; 2018–2021, Türkiye

Investigation of infant deaths associated with critical congenital heart diseases; 2018–2021, Türkiye

In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

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