Neonatal pemphigus in an infant born to a mother with serologic evidence of both pemphigus vulgaris and gestational pemphigoid

Panko, Jacqueline; Florell, Scott R.; Hadley, Jason C.; Zone, John J.; Leiferman, Kristin M.; Vanderhooft, Sheryll L.

doi:10.1016/j.jaad.2008.10.025

Cited by 29 publications

(21 citation statements)

References 15 publications

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“…To our knowledge only 29 cases of neonatal pemphigus have been reported in the literature. [18,25,26] In our series we found only one case of neonatal pemphigus (1.4%) born to a mother with mild oral PV. Her skin bullae resolved after a few weeks.…”

Section: Discussionmentioning

confidence: 52%

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Pemphigus and pregnancy: A 23-year experience

Daneshpazhooh¹,

Chams‐Davatchi²,

Valikhani³

et al. 2011

Indian J Dermatol Venereol Leprol

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Section: Discussionmentioning

confidence: 52%

“…In most reported cases, PV/vegetans was the underlying maternal diagnosis (26 out of 29 cases). [18,25,26] Only three cases of PF are yet to be reported. [27][28][29] It is postulated to be due to the different distribution of Dsg 1 and 3 in neonate and adult skin and mucosae.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus and pregnancy: A 23-year experience

Daneshpazhooh¹,

Chams‐Davatchi²,

Valikhani³

et al. 2011

Indian J Dermatol Venereol Leprol

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“…In pemphigoid gestationis, maternal IgG autoantibodies against bullous pemphigoid antigen 180 can cross the placenta and cause tense blisters in the neonate . In addition, mothers with pemphigus vulgaris may transfer IgG autoantibodies against desmoglein 3, leading to the formation of flaccid blisters in neonatal pemphigus vulgaris …”

Section: Discussionmentioning

confidence: 99%

“…4 In addition, mothers with pemphigus vulgaris may transfer IgG autoantibodies against desmoglein 3, leading to the formation of flaccid blisters in neonatal pemphigus vulgaris. 5 The clinical differential diagnosis for a newborn with scattered bullae is broad and includes other forms of EB, bullous variants of ichthyosis such as epidermolytic ichthyosis and icthyosis bullosa of Seimens, infectious etiologies such as herpes simplex and bullous impetigo and less commonly, autoimmune pemphigus and pemphigoid variants.…”

Section: Discussionmentioning

confidence: 99%

Dermal eosinophilic infiltrate in junctional epidermolysis bullosa

et al. 2015

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Junctional epidermolysis bullosa (JEB) is a rare genodermatosis characterized by a split in the lamina lucida usually because of mutations in LAMA3, LAMB3 and LAMC2 resulting in absence or reduction of laminin-332. Rare subtypes of JEB have mutations in COL17A1, ITGB4, ITGA6 and ITGA3 leading to reduction or dysfunction of collagen XVII, integrin α6β4 and integrin α3. The classic finding under light microscopy is a paucicellular, subepidermal split. We describe the unusual presence of an eosinophilic infiltrate in the bullae and subjacent dermis in a neonate with JEB, generalized intermediate (formerly known as non-Herlitz-type JEB), discuss the histologic differential diagnosis for a subepidermal blister in a neonate, review the literature regarding cases of epidermolysis bullosa (EB) presenting with inflammatory infiltrates, and discuss mechanisms to explain these findings. This case highlights that eosinophils can rarely be seen in EB and should not mislead the dermatopathologist into diagnosing an autoimmune blistering disorder.

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“…To our knowledge only 29 cases of neonatal pemphigus have been reported in the literature. [12][13][14] Neonatal pemphigus is an uncommon presentation in neonates, hence a rarely found neonatal autoimmune bullous disorder.…”

mentioning

confidence: 99%