Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior andc-fos mRNA expression in the brain

Semba, Junʼichi; Tanaka, Noriko; Wakuta, Maki; Suhara, Tetsuya

doi:10.1002/1098-2396(200104)40:1<11::aid-syn1021>3.0.co;2-i

Cited by 10 publications

(4 citation statements)

References 52 publications

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“…As reported previously (Semba et al . 2001), chronic PCP influenced bodyweight gain in neonatal but not in adult rats.…”

Section: Resultssupporting

confidence: 86%

“…According to the neurodevelopmental hypothesis of schizophrenia, disturbed BDNF expression during development may alter the normal program of brain maturation, thus producing long‐lasting changes in brain function and activity. Our study suggests that malformation of the hippocampus in schizophrenia (Harrison 2004) might represent the consequence of reduced synthesis of BDNF that results from NMDA receptor dysfunction caused by several brain insults, including PCP exposure in the perinatal period (Semba et al . 2001; Wang et al .…”

Section: Discussionmentioning

confidence: 95%

“…1997) during adult period. This finding suggests the possibility that disturbed NMDA receptor function during neuronal development may induce neurodevelopmental abnormality (Semba et al . 2001), hypothesized to be one of the major causes of the pathogenesis of schizophrenia (Weinberger 1987).…”

Section: Introductionmentioning

confidence: 93%

“…2004). This finding suggests that disturbed NMDA receptor function during neuronal development may induce neurodevelopmental abnormality (Semba et al . 2001), which results in behavioral abnormalities, such as the deficits in prepulse inhibition of acoustic startle (Wang et al .…”

Section: Introductionmentioning

confidence: 99%

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PRECLINICAL STUDY: Different effects of chronic phencyclidine on brain‐derived neurotrophic factor in neonatal and adult rat brains

Semba

Wakuta

Suhara³

2006

Addiction Biology

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The N-methyl-D-aspartate (NMDA) receptor and brain-derived neurotrophic factor (BDNF) are both known to play major roles in the normal development of the brain. We have hypothesized that the chronic blockade of NMDA with phencyclidine (PCP) may have a different effect on BDNF synthesis at different stages of development. In an acute experiment, rat pups and adult rats were injected with PCP (2.5, 5 or 10 mg/kg) at postnatal day (PD) 15 or 49, respectively. In a chronic experiment, rat pups were injected daily from PD 5 to PD 14 with PCP (2.5, 5 or 10 mg/kg), while adult rats were injected daily with the same dose from PD 39 to PD 48. BDNF levels in the hippocampus, striatum and frontal cortex were determined by ELISA assay 24 hours after the last injection. Chronic PCP treatment of neonatal rats induced a dose-dependent decrease in BDNF in the hippocampus but not in the frontal cortex and striatum. Single injection of PCP to rat pups showed a slight reduction of BDNF in the hippocampus but only at higher doses. In contrast to neonatal brain, neither acute nor chronic injection of PCP influenced BDNF in adult brain. These findings suggest that chronic blockade of NMDA receptor in the early neonatal period has an inhibitory effect on BDNF synthesis in the hippocampus and may impair normal neurodevelopment in rat pups.

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“…As reported previously (Semba et al . 2001), chronic PCP influenced bodyweight gain in neonatal but not in adult rats.…”

Section: Resultssupporting

confidence: 86%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

PRECLINICAL STUDY: Different effects of chronic phencyclidine on brain‐derived neurotrophic factor in neonatal and adult rat brains

Semba

Wakuta

Suhara³

2006

Addiction Biology

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Testing the validity of c-fos expression profiling to aid the therapeutic classification of psychoactive drugs

Sumner¹,

Cruise²,

Slattery³

et al. 2004

Psychopharmacology

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(i) Differences between drug classes support their classification by means of c-fos profiling. Differences within classes may reflect mechanistic variations. (ii) Greater downregulation in our experiments might be because of inclusion of low, clinically relevant, drug doses and fuller coverage of brain regions. (iii) The agreement between mirtazapine and imipramine increases our confidence in the validity of c-fos expression profiling to aid drug classification and predict therapeutic utility.

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Early brain development disruption from NMDA receptor hypofunction: Relevance to schizophrenia

Bois¹,

Huang²

2007

Brain Research Reviews

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Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior andc-fos mRNA expression in the brain

Cited by 10 publications

References 52 publications

PRECLINICAL STUDY: Different effects of chronic phencyclidine on brain‐derived neurotrophic factor in neonatal and adult rat brains

PRECLINICAL STUDY: Different effects of chronic phencyclidine on brain‐derived neurotrophic factor in neonatal and adult rat brains

Testing the validity of c-fos expression profiling to aid the therapeutic classification of psychoactive drugs

Early brain development disruption from NMDA receptor hypofunction: Relevance to schizophrenia

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