Neonatal polycystic encephalomalacia: four new cases and review of the literature.

Chutorian, Abe M.; Michener, Robert C.; Defendini, Richard; Hilal, Sadek K.; Gamboa, Eugenia T.

doi:10.1136/jnnp.42.2.154

Cited by 22 publications

(2 citation statements)

References 20 publications

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“…One patient (case 1) had polycystic cavitation of the hemisphere, but in this case Escherichia coli was isolated from the cavitation. This multicystic encephalomalacia has been reported in autopsy findings in congenital syphilis [16], toxoplasmosis [17] and neonatal HSVE [15]. These findings are consistent With severe necrotizing meningoencephalitis [18].…”

Section: Discussionsupporting

confidence: 84%

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Computed tomography in young children with herpes simplex virus encephalitis

et al. 1985

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Computed tomographic (CT) scans were obtained from eight infants and young children with herpes simplex virus encephalitis. In two cases the initial scan showed diffuse edematous changes as a mass effect without laterality. Unilateral localized low attenuation in the initial scan was evident 4 days after the onset in one patient, and high attenuation in the initial scan appeared on the 6th day in another patient, but in general, it was not possible to establish an early diagnosis of herpes simplex virus encephalitis from CT scan. In the longitudinal study the calcification with ventriculomegaly appeared in 3 of 5 survivors, and gyriform calcification in 2 of 3 patients, respectively. The appearance of multicystic encephalomalacia was evident in one patient 6 months after the onset of neonatal herpes simplex encephalitis. It is shown that the CT findings of neonates and young children with herpes simplex encephalitis are different from those of older children and adults, and the importance of longitudinal CT studies was stressed in clarifying the pathophysiology of the central nervous system involvement in survivors.

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Section: Discussionsupporting

confidence: 84%

“…In our study, there was one more interesting appearance of CT in neonates with HSVE, which was the multicystic encephalomalacia [14,15] in case2 (Fig. 2 d).…”

Section: Discussionmentioning

confidence: 88%