Neonatal Presentation of an Air-Filled Neck Mass that Enlarges with Valsalva: A Case Report

Patel, Jasminkumar Bharatbhai; Kilbride, Howard W.; Paulson, Lorien M.

doi:10.1055/s-0035-1563388

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…The burden of infection due to the MRSA strains is significantly more evident in children than in other age groups [ 72 ]. S. aureus colonization of the nasopharynx begins very early, in the first six months of life [ 73 ]. The use of the LF3872 strain as a probiotic may help in the prevention and eradication of antibiotic-resistant S. aureus in the nasopharynx and oral cavity in humans.…”

Section: Resultsmentioning

confidence: 99%

Limosilactobacillus fermentum 3872 That Produces Class III Bacteriocin Forms Co-Aggregates with the Antibiotic-Resistant Staphylococcus aureus Strains and Induces Their Lethal Damage

et al. 2023

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LF3872 was isolated from the milk of a healthy lactating and breastfeeding woman. Earlier, the genome of LF3872 was sequenced, and a gene encoding unique bacteriocin was discovered. We have shown here that the LF3872 strain produces a novel thermolabile class III bacteriolysin (BLF3872), exhibiting antimicrobial activity against antibiotic-resistant Staphylococcus aureus strains. Sequence analysis revealed the two-domain structural (lysozyme-like domain and peptidase M23 domain) organization of BLF3872. At least 25% residues of this protein are expected to be intrinsically disordered. Furthermore, BLF3872 is predicted to have a very high liquid-liquid phase separation. According to the electron microscopy data, the bacterial cells of LF3872 strain form co-aggregates with the S. aureus 8325-4 bacterial cells. LF3872 produced bacteriolysin BLF3872 that lyses the cells of the S. aureus 8325-4 mastitis-inducing strain. The sensitivity of the antibiotic-resistant S. aureus collection strains and freshly isolated antibiotic-resistant strains was tested using samples from women with lactation mastitis; the human nasopharynx and oral cavity; the oropharynx of pigs; and the cows with a diagnosis of clinical mastitis sensitive to the lytic action of the LF3872 strain producing BLF3872. The co-cultivation of LF3872 strain with various antibiotic-resistant S. aureus strains for 24 h reduced the level of living cells of these pathogens by six log. The LF3872 strain was found to be able to co-aggregate with all studied S. aureus strains. The cell-free culture supernatant of LF3872 (CSLF3872) induced S. aureus cell damage and ATP leakage. The effectiveness of the bacteriolytic action of LF3872 strain did not depend on the origin of the S. aureus strains. The results reported here are important for the creation of new effective drugs against antibiotic-resistant strains of S. aureus circulating in humans and animals.

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Section: Resultsmentioning

confidence: 99%

Limosilactobacillus fermentum 3872 That Produces Class III Bacteriocin Forms Co-Aggregates with the Antibiotic-Resistant Staphylococcus aureus Strains and Induces Their Lethal Damage

et al. 2023

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“…Almost all published cases of airway obstruction due to an air‐filled third or fourth branchial pouch sinus were treated surgically. Only rarely are percutaneous puncture and electrocautery sufficient to treat an air‐filled third or fourth branchial pouch sinus 4 . It seems reasonable to consider endoscopic cauterization of the piriform sinus opening as the first treatment option for air‐filled sinuses because it is minimally invasive and can be performed directly following diagnostic pharyngolaryngoscopy.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Cauterization and Sclerotherapy for Airway Obstruction by a Third Branchial Pouch Sinus

et al. 2020

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“…The adverse impact of neonatal PSF is dependent on its size and location and on the presence of neck infections ( 34 ). After oral feeding, the size of the neck mass gradually increases in some cases ( 32 , 44 ), which may lead to tracheal compression.…”

Section: Discussionmentioning

confidence: 99%

Pyriform Sinus Fistula in the Fetus and Neonate: A Systematic Review of Published Cases

Chen

Sheng

et al. 2020

Front. Pediatr.

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Purpose: To provide recommendations for the diagnosis and treatment of pyriform sinus fistula (PSF) in the fetus and neonate through a systematic review of the published literature. Methods: PubMed and Embase (1968-2019) were searched, and additional publications were obtained by searching the references by hand. The two reviewers assessed all papers and extracted the following variables: demographics, clinical features, diagnostic tests, interventions, and prognoses. Results: Forty-two papers were included, comprising a total of 158 cases. PSF presented almost exclusively on the left side (95.56%). Patients usually presented with a neck mass (100%) and respiratory distress (43.18%). The false-negative rate (FNR) of prenatal ultrasonography (US) was significantly higher than that of prenatal magnetic resonance imaging (MRI) (P < 0.01). For the diagnosis of PSF in neonates, computerized tomography (CT) and MRI were the most accurate diagnostic modalities. Ex utero intrapartum treatment (EXIT) was performed during delivery in 6 patients (26.09%). Among 135 patients with a reported date of definitive surgery, 117 (86.67%) underwent surgery during the neonatal period. Complications after definitive surgery appeared in 5 patients (3.16%), and all of them recovered spontaneously within 3 months. Furthermore, recurrence occurred in 4 patients (2.53%). Conclusion: In fetal cases with PSF suspected by US, MRI is necessary to confirm the diagnosis. During the neonatal period, patients with PSF typically present with a neck mass and respiratory distress, and CT/MRI appears to be the preferred diagnostic method. Definitive surgery is effective for treating neonatal PSF, with a low complication rate and low recurrence rate.

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Neonatal Presentation of an Air-Filled Neck Mass that Enlarges with Valsalva: A Case Report

Cited by 7 publications

References 28 publications

Limosilactobacillus fermentum 3872 That Produces Class III Bacteriocin Forms Co-Aggregates with the Antibiotic-Resistant Staphylococcus aureus Strains and Induces Their Lethal Damage

Limosilactobacillus fermentum 3872 That Produces Class III Bacteriocin Forms Co-Aggregates with the Antibiotic-Resistant Staphylococcus aureus Strains and Induces Their Lethal Damage

Endoscopic Cauterization and Sclerotherapy for Airway Obstruction by a Third Branchial Pouch Sinus

Pyriform Sinus Fistula in the Fetus and Neonate: A Systematic Review of Published Cases

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