Neonatal reflexes and behavior in hypertensive rats of ISIAH strain

Ragaeva, D. S.; Tikhonova, Maria A.; Petrova, Olga; Igonina, T. N.; Rozkova, Irina N.; Brusentsev, E. Yu.; Amstislavskaya, Tamara G.; Amstislavsky, S. Ya.

doi:10.1016/j.physbeh.2017.03.026

Cited by 7 publications

(3 citation statements)

References 61 publications

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“…Reduced anxiety, as measured by time in the center of an open field and deficits in inhibitory sensorimotor gating, as determined by PPI of an ASR, are consistent with previous studies in chronic hypertensive rat models [64–66], but have not yet been linked to behavior in initial hypertensive stages. Here, we show that these alterations occur early and persist in chronic hypertension.…”

Section: Discussionsupporting

confidence: 89%

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Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Ulbrich

Morton

Briese

et al. 2023

Preprint

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Chronic arterial hypertension causes cerebral microvascular dysfunction and doubles dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease duration, the degree of irreversible tissue damage and whether microvascular function can be restored. This study aimed to understand molecular and cellular temporo-spatial pathomechanisms in the course of hypertension. We investigated the effects of initial, early chronic and late chronic hypertension in the frontal brain of rats by applying behavioral tests, histopathology, immunofluorescence, FACS, microvascular/neural tissue RNA sequencing as well as 18F-FDG PET imaging. Chronic hypertension caused frontal brain-specific behavioral deficits. Our results highlight stage-dependent responses to continuous microvascular stress and wounding by hypertension. Early responses included a fast recruitment of activated microglia to the blood vessels, immigration of peripheral immune cells, blood-brain-barrier leakage and an energy-demanding hypermetabolic state. Vascular adaptation mechanisms were observed in later stages and included angiogenesis and vessel wall strengthening by upregulation of cellular adhesion molecules and extracellular matrix. Additionally, we identified late chronic accumulation of Igfbp-5 in the brains of hypertensive rats, which is also a signature of Alzheimer dementia and attenuates protective Igf-1 signaling. Our study advances the knowledge of involved pathomechanisms and highlights the stage-dependent nature of hypertensive pathobiology. This groundwork might be helpful for basic and clinical research to identify stage-dependent markers in the human disease course, investigate stage-dependent interventions besides blood pressure lowering and better understand the relationship between poor vascular health and neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 89%

Section: Behavioral Changes and Cognitive Impairmentssupporting

confidence: 89%

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Ulbrich

Morton

Briese

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The accelerated aging in OXYS rats is associated with a reduction in locomotor and exploratory activities and in learning, as well as with memory deficits against a background of the emergence of other key signs of AD. On the contrary, ISIAH rats are characterized by increased exploratory activity and are less anxious than control normotensive rats [39]. Nonetheless, our findings suggest that hypertension pathogenesis in OXYS rats may be similar to that in ISIAH/Icgn rats, which have a large number of common SNPs with OXYS rats.…”

Section: Discussionmentioning

confidence: 51%

Single-Nucleotide Polymorphisms (SNPs) Both Associated with Hypertension and Contributing to Accelerated-Senescence Traits in OXYS Rats

Devyatkin

Redina

Muraleva

et al. 2020

IJMS

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Aging is a major risk factor of numerous human diseases. Adverse genetic variants may contribute to multiple manifestations of aging and increase the number of comorbid conditions. There is evidence of links between hypertension and age-related diseases, although the genetic relationships are insufficiently studied. Here, we investigated the contribution of hypertension to the development of accelerated-senescence syndrome in OXYS rats. We compared transcriptome sequences of the prefrontal cortex, hippocampus, and retina of OXYS rats with the genotypes of 45 rat strains and substrains (which include models with hypertension) to find single-nucleotide polymorphisms (SNPs) both associated with hypertension and possibly contributing to the development of age-related diseases. A total of 725 polymorphisms were common between OXYS rats and one or more hypertensive rat strains/substrains being analyzed. Multidimensional scaling detected significant similarities between OXYS and ISIAH rat genotypes and significant differences between these strains and the other hypertensive rat strains/substrains. Nonetheless, similar sets of SNPs produce a different phenotype in OXYS and ISIAH rats depending on hypertension severity. We identified 13 SNPs causing nonsynonymous amino-acid substitutions having a deleterious effect on the structure or function of the corresponding proteins and four SNPs leading to functionally significant structural rearrangements of transcripts in OXYS rats. Among them, SNPs in genes Ephx1, Pla2r1, and Ccdc28b were identified as candidates responsible for the concomitant manifestation of hypertension and signs of accelerated aging in OXYS rats.

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Effects ofin vitroculture at the preimplantation embryo stage on early development and hypertension in ISIAH rats

Igonina

Ragaeva

Petrova

et al. 2019

Hypertension in Pregnancy

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Neonatal reflexes and behavior in hypertensive rats of ISIAH strain

Cited by 7 publications

References 61 publications

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Single-Nucleotide Polymorphisms (SNPs) Both Associated with Hypertension and Contributing to Accelerated-Senescence Traits in OXYS Rats

Effects ofin vitroculture at the preimplantation embryo stage on early development and hypertension in ISIAH rats

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