Neonatal Response to DTP Vaccines

Goerke, Laszlo; Roberts, Pauline; Chapman, John

doi:10.2307/4590169

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Maternal antibodies against FHA and LPT were detected in cord blood, consistent with reports that there is placental transfer of antibodies to B. pertussis (2,10,16,21,26). The duration of maternal antibody in the infant and its role in passive protection from pertussis disease were not determined in this study.…”

Section: Discussionsupporting

confidence: 89%

“…In the United States, current medical practice recommends that immunization begin at 2 months of age, or earlier in areas of high endemicity (22). Previous studies to assess the immune response to pertussis vaccines or B. pertussis infection have employed agglutination-type assays (1,2,8,12,13,16,27,30,40,41), complement fixation (7,23,24), bactericidal assays (3), and enzyme-linked immunosorbent assays (ELISA) (17,33,39). Since whole cells or disrupted whole cell preparations were used as antigens in these assays, it VOL.…”

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confidence: 99%

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Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis

Burstyn¹,

Baraff²,

Peppler³

et al. 1983

Infect Immun

101

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Serum antibody responses to the filamentous hemagglutinin and the lymphocytosis-promoting toxin of Bordetella pertussis after vaccination with diphtheria and tetanus toxoids and pertussis vaccine, adsorbed, were assayed by using the enzyme-linked immunosorbent assay. The effect of early immunization, during the first week of life, on the antibody response also was determined. After vaccination, immunoglobulin G (IgG) and IgM directed against both the filamentous hemagglutinin and the lymphocytosis-promoting toxin were detected. Generally, antibody titers increased with subsequent injections and the age of the children. Maternal antibodies against filamentous hemagglutinin and lymphocytosis-promoting toxin were detected in cord blood. The ability of an infant to produce serum IgG anti-lymphocytosis-promoting toxin after vaccination with pertussis vaccine was inversely related to the cord blood serum IgG antilymphocytosis-promoting toxin titer at birth. A good antibody response was observed in infants with low cord blood titers, and a poor antibody response was seen in infants with high cord blood values. The IgM anti-lymphocytosispromoting toxin response was good in groups with both low and high cord blood titer, with no significant difference observed between the two groups. No IgA anti-lymphocytosis-promoting toxin or IgA anti-filamentous hemagglutinin titers were observed in vaccinees. IgA antibodies were observed in convalescent sera from two adults and may be presumptive evidence of infection with B. pertussis.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis

Burstyn¹,

Baraff²,

Peppler³

et al. 1983

Infect Immun

101

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Die Keuchhustenschutzimpfung

Vogt¹,

Engelhardt²

1965

Handbuch Der Schutzimpfungen

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Role of Maternal Pertussis Antibodies in Infants

Rie¹,

Wendelboe²,

Englund³

2005

Pediatric Infectious Disease Journal

104

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Pertussis remains a serious infection in young infants. Most deaths occur in the first 3 months of life, before administration of the first dose of pertussis vaccine. Pertussis antibodies are transferred from mother to infant; but because of the lack of serologic correlates of protection, it is difficult to determine the proportion of infants born with a protective concentration of maternal antibodies. Indirect evidence suggests that maternal antibodies provide short lived protection against fatal pertussis. It is hoped that the protection of young infants could be enhanced by maternal or neonatal vaccination. The possibility of protecting young infants against pertussis by immunizing their mothers during pregnancy was investigated in the 1930s and 1940s; no further studies have been published since. Recent animal and human studies have provided evidence that neonatal immunization with acellular pertussis vaccine can efficiently prime T and B cells and act as a basis for future immune response. The limited data on neonatal and maternal pertussis immunization are promising and call for further research to reduce the vulnerability of young infants to pertussis disease.

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Neonatal Response to DTP Vaccines

Cited by 4 publications

References 6 publications

Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis

Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis

Die Keuchhustenschutzimpfung

Role of Maternal Pertussis Antibodies in Infants

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