Neonatal screening: 9% of children with filter paper thyroid‐stimulating hormone levels between 5 and 10 μIU/mL have congenital hypothyroidism

Christensen-Adad, Flávia Corrêa; Mendes‐dos‐Santos, Carolina T.; Goto, Maura Mikie Fukujima; Sewaybricker, Letícia Espósito; D’Souza-Li, Lília; Guerra‐Júnior, Gil; Morcillo, André Moreno; Lemos-Marini, Sofia Helena Valente de

doi:10.1016/j.jpedp.2017.08.001

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The CP obtained in this study for TSH was < 5 µIU/mL and > 6 µg/dL for T4. Thus, we have that the CP for TSH in Spain, Bolivia, Paraguay, and Mexico is < 10 µIU/mL [20][21][22][23] , while in Brazil, it is 5-10 µIU/ mL 24 . In 2018, Flores-Robles et al, from the National Institute of Perinatology of Mexico, published a CP for TSH < 5 µIU/mL and T4 > 4.85 µg/dL for premature NBs 25 .…”

Section: Discussionmentioning

confidence: 99%

Determination and comparison of neonatal screening biomarker cutoff points in Mexican newborns against the manufacturerÓ?s cutoff point

Cobos-Puc¹,

Martínez-Tapia²,

Martínez-Castillo³

et al. 2023

RMU

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Objective:The objective of the study was to determine the cutoff points (CP) of nine neonatal screening biomarkers performed at the Laboratory of the Center for Neonatal and Genetic Studies in Mexico City, comparing them with the CP recommended by the manufacturer of the reagents. Materials and methods: A descriptive cross-sectional research was carried out. The study included 2805 newborns aged 1-30 days, who had a drop of dried whole blood collected on filter paper, then quantified for their concentrations of thyroid-stimulating hormone, thyroxine, phenylalanine, immunotrypsin, galactose-1-phosphate uridyltransferase, galactose, glucose-6-phosphate dehydrogenase, biotinidase, and 17-alpha hydroxyprogesterone, by immunofluorescence method (DELFIA, PerkinElmer LifeSciences time-resolved fluorometry). The cutoff point (excluding atypical values) was calculated with the data obtained for each test, and the mean and standard deviation were determined. Sensitivity and specificity were determined with receiver operating characteristic (ROC) curves. The determined CPs were compared with the CPs recommended by the manufacturer of the reagents. Results: Except for T4, it was shown that, when comparing the CP obtained, these were lower compared to the CPs recommended by the manufacturer. Conclusion: The CPs obtained in Mexican neonates differ from those recommended by the manufacturer. In addition, CPs are analytically acceptable, as they have high sensitivity and specificity. Consequently, these CPs can be used as a reference in clinical practice for the possible early detection of metabolic diseases in newborns.

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Section: Discussionmentioning

confidence: 99%

Determination and comparison of neonatal screening biomarker cutoff points in Mexican newborns against the manufacturerÓ?s cutoff point

Cobos-Puc¹,

Martínez-Tapia²,

Martínez-Castillo³

et al. 2023

RMU

View full text Add to dashboard Cite

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“…In 2018, Kilberg et al suggested that US neonatal screening programs were missing newborns with mild and persistent TSH elevations, who could have CH and its health consequences, due to the lack of adequate standardization of TSH values [ 15 ]. Christensen-Adad et al (2017) also demonstrated that 9% of children with TSH values between and 5–10 μIU/mL (screening test cut-off = 10 μIU/mL), who did not normalize these values over time, had CH that would not have been diagnosed by the national recommended cut-off value [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns

et al. 2021

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Objective This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test. Methods Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test was performed between three and seven days, and the ABR test was performed in the first 28 days of life. The newborns were divided into two groups: Group 1 (n = 35), TSH between 0 and 5μUI/mL, and group 2 (n = 27), TSH between 5 and 15μUI/mL. Data are presented as mean ± SD, median, or percentage, depending on the variable. Results Wave latency and interpeak interval values for Groups 1 and 2 were as follows: Wave I: 1.8 ± 0.1 and 1.7 ± 0.1; Wave III: 4.4 ± 0.1 and 4.4 ± 0.1; Wave V: 6.9 ± 0.1 and 6.9 ± 0.1; interval I–III: 2.6 ± 0.1 and 2.6 ± 0.1; interval I–V: 5.1 ± 0.1 and 5.1 ± 0.1; interval III–V: 2.4 ± 0.1 and 2.4 ± 0.1. There were no significant differences in ABR parameters between groups 1 and 2 (p > 0.05). Multiple regression analysis showed a slight significant negative correlation between TSH and wave I values (standardized β = −0.267; p = 0.036), without observing any relationship with the other ABR waves recorded. Conclusions This study investigated the relationship of TSH and auditory myelinization evaluated by ABR. It did not show a significant change in lower auditory pathway myelinization according to TSH levels in newborns with TSH screening levels lower than 15 μUI/mL.

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Neonatal screening: 9% of children with filter paper thyroid‐stimulating hormone levels between 5 and 10 μIU/mL have congenital hypothyroidism

Cited by 2 publications

References 28 publications

Determination and comparison of neonatal screening biomarker cutoff points in Mexican newborns against the manufacturerÓ?s cutoff point

Determination and comparison of neonatal screening biomarker cutoff points in Mexican newborns against the manufacturerÓ?s cutoff point

Neonatal thyrotropin levels and auditory neural maturation in full-term newborns

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