Neonatal screening and clinical care programmes for sickle cell disorders in sub-Saharan Africa: Lessons from pilot studies

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis

“…The outcome for patients with sickle cell anaemia could be improved with penicillin and malaria prophylaxis and with parental education for the identification of severe symptoms and malarial crises. 23 Even if such interventions have an aggregate effectiveness of 50%, the number of preventable deaths, 20 per year (24% of post-discharge deaths), suggests that targeting the segment of the population in which a large fraction of deaths is associated with hospital discharge might prove cost-effective.…”

Current status of newborn screening worldwide: 2015

“…Obviously missing is Sub-Saharan Africa for which little information is currently available, and limited congenital hypothyroidism (CH) and sickle cell NBS activities are ongoing. [13][14][15] A review of the literature and personal contacts working in Africa revealed documentation of various beginning newborn screening activities in Ghana, 16,17 Nigeria, 18 Tanzania, 19 Angola, 20 Ethiopia, 21 Democratic Republic of Congo, 22 and South Africa. 23,24 For the remainder of the world, we have drawn on our extensive NBS experience and contacts with NBS program managers within our respective regions to solicit recent updates in order to comprehensively describe ongoing regional NBS activities.…”

Evaluation <i>in vitro</i> de l’activité antifalcémiante et effet antioxydant des extraits <i>d’Uapaca heudelotii</i> Baill. (Euphorbiaceae)

“…La prévalence de l'allèle S qui varie de 15 et 20% est parmi les plus élevés en Afrique (Tshilolo et al, 2009 ;Agasa et al, 2010). Il est également bien établi qu'à la naissance, entre 1,8 et 2% des nouveaux nés sont atteints et que plus de 80% de ces enfants meurent avant l'âge de deux ans (Tshilolo et al, 2008).…”