Neonatal seizures associated with narcotic withdrawal

Herzlinger, Robert; Kandall, Stephen R.; Vaughan, Herbert G.

doi:10.1016/s0022-3476(77)80523-4

Cited by 134 publications

(37 citation statements)

References 17 publications

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“…Still, severe withdrawal has been described in 0 to 50% of buprenorphine-exposed infants. [53][54][55] In the acute phase, seizures have occurred in 2% to 11% of infants withdrawing from opioids 49,50,56 ; however, abnormal EEG results without overt seizure activity have been reported in >30% of neonates. 57,58 Subacute signs of opioid withdrawal may last up to 6 months.…”

Section: Clinical Presentation Of Opioid Withdrawalmentioning

confidence: 99%

Neonatal Drug Withdrawal

Hudak¹,

Tan²,

Frattarelli³

et al. 2012

Pediatrics

758

608

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Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information about the clinical presentation of infants exposed to intrauterine drugs and the therapeutic options for treatment of withdrawal and is expanded to include evidence-based approaches to the management of the hospitalized infant who requires weaning from analgesics or sedatives.

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Section: Clinical Presentation Of Opioid Withdrawalmentioning

confidence: 99%

Neonatal Drug Withdrawal

Hudak¹,

Tan²,

Frattarelli³

et al. 2012

Pediatrics

758

608

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“…Seizures are observed in 2% to 11% of neonates with NAS, are a serious manifestation of withdrawal, and should be treated immediately. 94 The exact cause of withdrawal-related seizure is unknown, although the threshold for seizure activity may be decreased due to upregulation of sodium channels as a result of receptor instability. 75 Heart rate, respiratory rate, muscle tone, and other physiologic responses to stimuli are impaired in these neonates with NAS as a result of the dysregulation and instability of the autonomic nervous system.…”

Section: Clinical Presentationmentioning

confidence: 99%

Neonatal Abstinence Syndrome

2014

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Neonatal abstinence syndrome (NAS) is a result of the sudden discontinuation of fetal exposure to substances that were used or abused by the mother during pregnancy. Withdrawal from licit or illicit substances is becoming more common among neonates in both developed and developing countries. NAS continues to be an important clinical entity throughout much of the world. NAS leads to a constellation of signs and symptoms involving multiple systems. The pathophysiology of NAS is not completely understood. Urine or meconium confirmation may assist the diagnosis and management of NAS. The Finnegan scoring system is commonly used to assess the severity of NAS; scoring can be helpful for initiating, monitoring, and terminating treatment in neonates. Nonpharmacological care is the initial treatment option, and pharmacological treatment is required if an improvement is not observed after nonpharmacological measures or if the infant develops severe withdrawal. Morphine is the most commonly used drug in the treatment of NAS secondary to opioids. An algorithmic approach to the management of infants with NAS is suggested. Breastfeeding is not contraindicated in NAS, unless the mother is taking street drugs, is involved in polydrug abuse, or is infected with HIV. Future studies are required to assess the long-term effects of NAS on children after prenatal exposure.

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“…Kol ve bacaklarda genellikle daha abartılı ve kaba hareketler göze çarpar. Kolların hareketi kanat çırpmayı andırır (11,(12)(13)(14). Ek olarak NYS'li bebeklerin %30'unda anormal EEG bulguları gözlenmiştir (15).…”

Section: Discussionunclassified

“…Gastrointestinal sisteme ait bulgular: artmış emme, kötü beslenme, sulu dışkılama, kusma veya regürjitasyon gibi bulgular ile karşımıza çıkabilir (12)(13)(14). Bunlardan en önemlisi beslenme yetersizliğidir.…”

Section: Discussionunclassified

Neonatal yoksunluk sendromu olan prematüre bebek

Özdemiroğlu¹,

Kara²,

Kurt³

et al. 2014

Ege Tıp Dergisi

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ÖzetNeonatal yoksunluk sendromu (NYS) prenatal bağımlılık yapan maddelere maruziyet sonrası çekilme semptomlarıyla ve fiziksel bağımlılıkla karakterize klinik bir durumdur. Opioid dışındaki tüm ilaç sınıfları için bu belirtiler genellikle kendi kendini sınırlar ve farmakolojik tedavi gerektirmez. Gelişmiş ülkelerde hamile kadınların %4.4'ü yasadışı ilaç kullanmaktadır. Gebelik boyunca eroine maruziyet prematürite, açıklanamayan intrauterin gelişme geriliği, plasenta yetmezliği, doğum sonrası kanama, preeklampsi ve erken membran rüptürü de dahil olmak üzere fetal ölüm ve neonatal morbidite ile ilişkilidir. Ülkemizde neonatal yoksunluk sendromu ile doğan bebeklerle ilgili oldukça sınırlı sayıda olgu sunumu yapılmıştır.Anahtar Sözcükler: Prematürite, yoksunluk sendromu, eroin, kokain. Summary Neonatal abstinence syndrome (NYS) is a clinical condition characterized by physical dependence and withdrawal

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Neonatal seizures associated with narcotic withdrawal

Cited by 134 publications

References 17 publications

Neonatal Drug Withdrawal

Neonatal Drug Withdrawal

Neonatal Abstinence Syndrome

Neonatal yoksunluk sendromu olan prematüre bebek

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