Neonatal seizures: the Dublin Collaborative Study.

Curtis, P; Matthews, Tom; Clarke, T. A.; Darling, Michael; Crowley, Patricia; Griffin, E; O’Connell, Paul; Gorman, W.; O’Brien, Niall; O’Herlihy, Colm

doi:10.1136/adc.63.9.1065

Cited by 43 publications

(9 citation statements)

References 8 publications

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“…What are the characteristics of the infant or child who will later develop PNE? After the signs of the acute neonatal encephalopathy subside, our patients with persistent clinical deficits (Curtis et al, 1988) such as MR, CP, or both, were the ones to develop PNE. No patient had epilepsy who did not have other signs of CNS abnormality.…”

Section: Discussionmentioning

confidence: 81%

Postnatal Epilepsy After EEG‐Confirmed Neonatal Seizures

1991

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We examined infants whose neonatal seizures were confirmed by randomly recorded ictal EEG tracings to determine the types and frequency of postnatal epilepsy (PNE)--unprovoked, recurring postnatal seizures. Perinatal and postnatal clinical and EEG variables were also examined for their relevance to PNE. Forty infants with EEG-documented neonatal seizures of diverse etiologies were studied. The 27 survivors were followed for a mean of 31 months. PNE developed in 56% (15 of 27) of the cohort. The first seizure appeared at a mean-corrected age of 12.7 months and occurred despite ongoing antiepileptic medication in 60% (9 of 15) of the group. Seizures were classified as infantile spasms or minor motor (7 patients), complex partial (4 patients), or generalized tonic-clonic (4 patients). Perinatal variables that significantly correlated with PNE included the presence of coma but not the age at seizure onset, the estimated gestational age, or Apgar scores. PNE occurred in 68% (13 of 19) of patients with moderately or markedly abnormal EEG backgrounds but in only 25% (2 of 8) without (p = 0.035). There was a strong trend for PNE to develop in patients with greater than 10 electrographic seizures per hour but in only 45% (9 of 20) of infants with fewer seizures (p = 0.058). Several postnatal variables were significantly related to PNE--the presence of cerebral palsy (CP), mental retardation (MR), CP with MR, and follow-up EEGs. PNE occurred in only 27% (3 of 11) of patients without spikes or sharp waves on postnatal EEGs performed at age 3 months but in 100% (3 of 3) of patients with spikes or sharp waves (p = 0.022).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 81%

Postnatal Epilepsy After EEG‐Confirmed Neonatal Seizures

1991

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“…In the Dublin collaborative study conducted by P D Curtis, T G Mathews, T A Clarke et al, meconium staining did not occur in half the babies with seizures. 21 Most of the infants in this study who developed seizures were born by normal delivery. In the Dublin study, 21 infants who developed seizures were more likely to be borne by LSCS or assisted breech delivery.…”

Section: Abnormality In Eeg Frequency (N=14) Percentagementioning

confidence: 88%

CLINICAL PROFILE, AETIOLOGY & EEG CHARACTERISTICS OF NEONATAL SEIZURES

Dhanyalaxmi¹,

S²

2018

jebmh

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BACKGROUNDSeizures are a common neonatal neurologic emergency, affecting approximately 1-4 per 1000 live births. The first 28 days of life (defining the neonatal period) represents the period of greatest seizure hazard during human life span.The aim of the study is to evaluate the aetiology, clinical profile and EEG profile neonatal seizures. MATERIALS AND METHODSA prospective Hospital based observational study was conducted including 205 neonatal infants presenting with seizures in Government Tertiary Teaching Hospital, Kozhikode, Kerala for a period of one year between January 1, 2008 and December 31, 2008 (1 year). The demographic data, clinical presentations, laboratory reports and result of treatment were observed, analysed and reported. RESULTS 205 new born infants were admitted in NICU with seizures. 17,121 babies including inborn and out born infants took treatment in this Hospital. Out of which 205 infants who developed seizures were included in this study. The incidence of seizures is 4.2 per 1000 among inborn babies. There were 126 male infants and the remaining 79 female infants. The gestational age of the mother was full term in 183 (89.3%) and only 2% of the babies were less than 32 weeks of gestation. The antenatal risk factors leading to seizures in infants was none in 169 (82.4%) mothers. 131 (63.9%) infants were born by normal delivery, by lower segment caesarean section in 47 (22.9%), vacuum extraction in 13 (06.3%) and forceps delivery & assisted breach in 07 (3.4%) of the infants. The birth weight was more than 2500 grams in 144 (70.24%), 2000 to 2500 grams in 40/205 infants (19.51%) and 100 to 2000 grams in 18 (08.78%) infants. CONCLUSIONThe overall incidence of neonatal seizures in babies born in our hospital was 4.2 per 1000 live births. Perinatal asphyxia was the most common cause of neonatal seizures, followed by hypoglycaemia. Tonic seizures were the most common type of seizures followed by subtle seizures. Among the babies whose EEG was done, abnormal EEG was recorded in 9.5%. Mortality was highest in babies who developed seizures in first 24 hours of life and in babies born by assisted breech delivery.

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“…Older series did not usually discriminate between term and preterm infants and reported higher incidence figures because many of the cases were due to late-onset hypocalcaemia [5]. The incidence of early (< 48h) seizures in term infants also varies, being 0.87 per 1,000 in Dublin between 1980-1984 [10] [27]. Subtle seizures are the most common type, particularly in premature infants, being present in 75% of the cases described by Sher et al [37].…”

Section: Incidencementioning

confidence: 96%

“…Seizures occur in 6%-13% of very low birth weight infants, and in 1-2 per 1,000 of infants born at term [10,27,28,31,44]. Older series did not usually discriminate between term and preterm infants and reported higher incidence figures because many of the cases were due to late-onset hypocalcaemia [5].…”

Section: Incidencementioning

confidence: 97%

Neonatal seizures

Rennie¹

1997

European Journal of Pediatrics

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The newborn brain is particularly vulnerable to seizures which are associated with poor neurodevelopmental outcome. The clinical manifestations of seizures in infants differ from those seen in older children and adults. The problem of electro-clinical dissociation, where there is no temporal correspondence between electrical paroxysms and repetitive stereotyped motor phenomena, is common in the newborn. There is at present very little information on which clinicians can base a rational decision about treatment which is often ineffective and does not alter neurodevelopmental outcome. This review summarizes current knowledge regarding investigation, treatment and prognosis of neonatal seizures.

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Neonatal seizures: the Dublin Collaborative Study.

Cited by 43 publications

References 8 publications

Postnatal Epilepsy After EEG‐Confirmed Neonatal Seizures

Postnatal Epilepsy After EEG‐Confirmed Neonatal Seizures

CLINICAL PROFILE, AETIOLOGY & EEG CHARACTERISTICS OF NEONATAL SEIZURES

Neonatal seizures

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